Powders in Pharmaceuticals

Overview of Powders in Pharmaceutical Formulations

• Powders are solid or mixture of solids reduced to a finely divided state intended for internal or external use.
• Properly prepared powders have a uniform, small particle size that has an elegant appearance and are more stable than liquid dosage forms.
• The properties of powders are related to the size and surface area of the particles, which must be considered in mixing, storing, and shipping.
• Topical powders should have a uniform, small particle size that will not irritate the skin when applied and should adhere to the skin.
• Highly sorptive powders should not be used for topical powders that are to be applied to oozing wounds.
• Insufflated powders are finely divided powders that are intended to be applied in a body cavity, such as the ears, nose, vagina, tooth socket, or throat.
• Before using powders in the preparation of pharmaceutical products, solid materials are characterized to determine their chemical and physical features.
• The particle size of a given powder is characterized by the United States Pharmacopeia (USP) using descriptive terms such as very coarse, coarse, moderately coarse, fine, and very fine.
• Drug micronization can increase the rate of drug dissolution and its bioavailability.
• Fine dispersions have particles ~0.5 to 10 μm, and particles intended to be inhaled for deposition deep in the respiratory tract are ~1 to 5 μm.
• A lack of grittiness of solid particles is essential in dermal ointments, creams, and ophthalmic preparations.
• Powders should be dispensed in tight containers to prevent exposure to atmospheric conditions, and talc or any other naturally derived product that is to be used on open wounds should first be sterilized to avoid infection.

Test your knowledge on the properties and uses of powders in pharmaceutical formulations with this quiz. Learn about the importance of particle size and surface area, the different types of topical and insufflated powders, and the characterization of solid materials for use in pharmaceutical products. Explore how drug micronization can improve bioavailability and the criteria for powders used in dermal ointments, creams, and ophthalmic preparations. Take this quiz to enhance your understanding of powders in pharmaceuticals.