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Pharmaceuticals: Instabilities of Powders and Suppositories

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Pharmaceuticals: Instabilities of Powders and Suppositories

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Questions and Answers

What is the primary cause of liquification and degradation of powders?

Isomerization of molecules

Absorption of water (correct)

Exposure to light

Autoxidation reaction

Which type of container is recommended to prevent light-induced degradation of dyes?

Tight containers with UV filters

Plastic containers

Amber glass bottles (correct)

Clear glass bottles

What is the purpose of adding stabilizers to suspensions?

To prevent crystal growth

To enhance the solubility of the solute

To prevent caking of suspensions (correct)

To increase the viscosity of the suspending medium

What is the primary function of surfactants in suspensions?

To enhance the wetting of the solute Signup and view all the answers

What is the primary cause of softening of gelatin capsules?

Absorption of water Signup and view all the answers

What is the primary function of tight containers in preventing physical instabilities?

To prevent absorption of water Signup and view all the answers

Which of the following pharmaceutical products is most likely to undergo hydrolytic degradation?

Esters Signup and view all the answers

What is the primary mechanism of degradation caused by light?

Photolysis Signup and view all the answers

Which analytical technique is most suitable for identifying chemical changes in a drug substance?

FTIR Signup and view all the answers

What is the primary purpose of using amber glass bottles in pharmaceutical packaging?

To protect from light Signup and view all the answers

Which type of degradation involves the rearrangement of molecular structure?

Isomerization Signup and view all the answers

What is the primary mechanism of degradation that involves the combination of molecules to form a larger molecule?

Polymerization Signup and view all the answers

What is the primary purpose of adding humectants to oil/water creams?

To prevent water loss from the dosage form Signup and view all the answers

What is the primary factor influencing the physical stability of a drug substance?

All of the above Signup and view all the answers

What is the purpose of visual inspection in physical stability evaluation?

To monitor changes in color, appearance, and uniformity Signup and view all the answers

What is the consequence of physical instability in saturated solutions?

Precipitation of crystals as a solid Signup and view all the answers

What is the primary method of preventing physical instability in creams?

Storing the cream in tight containers Signup and view all the answers

What is the purpose of microscopy in physical stability evaluation?

To examine particle morphology and size distribution Signup and view all the answers