Pharmaceuticals: Instabilities of Powders and Suppositories
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Questions and Answers

What is the primary cause of liquification and degradation of powders?

  • Isomerization of molecules
  • Absorption of water (correct)
  • Exposure to light
  • Autoxidation reaction

Which type of container is recommended to prevent light-induced degradation of dyes?

  • Tight containers with UV filters
  • Plastic containers
  • Amber glass bottles (correct)
  • Clear glass bottles

What is the purpose of adding stabilizers to suspensions?

  • To prevent crystal growth
  • To enhance the solubility of the solute
  • To prevent caking of suspensions (correct)
  • To increase the viscosity of the suspending medium

What is the primary function of surfactants in suspensions?

<p>To enhance the wetting of the solute (A)</p> Signup and view all the answers

What is the primary cause of softening of gelatin capsules?

<p>Absorption of water (B)</p> Signup and view all the answers

What is the primary function of tight containers in preventing physical instabilities?

<p>To prevent absorption of water (C)</p> Signup and view all the answers

Which of the following pharmaceutical products is most likely to undergo hydrolytic degradation?

<p>Esters (D)</p> Signup and view all the answers

What is the primary mechanism of degradation caused by light?

<p>Photolysis (D)</p> Signup and view all the answers

Which analytical technique is most suitable for identifying chemical changes in a drug substance?

<p>FTIR (D)</p> Signup and view all the answers

What is the primary purpose of using amber glass bottles in pharmaceutical packaging?

<p>To protect from light (C)</p> Signup and view all the answers

Which type of degradation involves the rearrangement of molecular structure?

<p>Isomerization (D)</p> Signup and view all the answers

What is the primary mechanism of degradation that involves the combination of molecules to form a larger molecule?

<p>Polymerization (A)</p> Signup and view all the answers

What is the primary purpose of adding humectants to oil/water creams?

<p>To prevent water loss from the dosage form (B)</p> Signup and view all the answers

What is the primary factor influencing the physical stability of a drug substance?

<p>All of the above (D)</p> Signup and view all the answers

What is the purpose of visual inspection in physical stability evaluation?

<p>To monitor changes in color, appearance, and uniformity (D)</p> Signup and view all the answers

What is the consequence of physical instability in saturated solutions?

<p>Precipitation of crystals as a solid (C)</p> Signup and view all the answers

What is the primary method of preventing physical instability in creams?

<p>Storing the cream in tight containers (C)</p> Signup and view all the answers

What is the purpose of microscopy in physical stability evaluation?

<p>To examine particle morphology and size distribution (D)</p> Signup and view all the answers

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