18 Questions
What is the primary cause of liquification and degradation of powders?
Absorption of water
Which type of container is recommended to prevent light-induced degradation of dyes?
Amber glass bottles
What is the purpose of adding stabilizers to suspensions?
To prevent caking of suspensions
What is the primary function of surfactants in suspensions?
To enhance the wetting of the solute
What is the primary cause of softening of gelatin capsules?
Absorption of water
What is the primary function of tight containers in preventing physical instabilities?
To prevent absorption of water
Which of the following pharmaceutical products is most likely to undergo hydrolytic degradation?
Esters
What is the primary mechanism of degradation caused by light?
Photolysis
Which analytical technique is most suitable for identifying chemical changes in a drug substance?
FTIR
What is the primary purpose of using amber glass bottles in pharmaceutical packaging?
To protect from light
Which type of degradation involves the rearrangement of molecular structure?
Isomerization
What is the primary mechanism of degradation that involves the combination of molecules to form a larger molecule?
Polymerization
What is the primary purpose of adding humectants to oil/water creams?
To prevent water loss from the dosage form
What is the primary factor influencing the physical stability of a drug substance?
All of the above
What is the purpose of visual inspection in physical stability evaluation?
To monitor changes in color, appearance, and uniformity
What is the consequence of physical instability in saturated solutions?
Precipitation of crystals as a solid
What is the primary method of preventing physical instability in creams?
Storing the cream in tight containers
What is the purpose of microscopy in physical stability evaluation?
To examine particle morphology and size distribution
This quiz covers the physical instabilities of powders and suppositories, including liquification, degradation, and changes in crystalline form. Learn how to prevent these instabilities and ensure the quality of pharmaceutical products.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
