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Polyketides

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Questions and Answers

What is the difference between Type 1 and Type 2 PKS?

Type 1 PKSs make simpler polyketides than Type 2 PKSs

Type 1 PKSs can be reprogrammed for each cycle, while Type 2 PKSs cannot be modified

Type 2 PKSs can be engineered to produce libraries of new compounds, while Type 1 PKSs cannot be modified

Type 2 PKSs use a set of enzymes repeatedly, while Type 1 PKSs use a new set of enzymes every cycle (correct)

What are some characteristics of aromatic polyketides?

They are built from branched versions of malonyl CoA and have little or no b-ketone processing

They are built from multiple malonyl units and undergo extensive b-ketone processing (correct)

They are built from a wider range of starter and extender units than other polyketides

They are built from organic acids that introduce branches into the chain

What is the purpose of engineering the biosynthesis of new compounds using polyketide biosynthesis knowledge?

To increase the yields of valuable compounds (correct)

To make the compounds less diverse

To make the biosynthesis process more complicated

To decrease the yields of valuable compounds

What is the process of polyketide biosynthesis similar to?

Fatty acid biosynthesis Signup and view all the answers

Which type of PKS makes simpler polyketides than modular systems?

Type 1 covalently linked enzymes Signup and view all the answers

What is the difference between Type 1 and Type 2 PKSs?

Type 1 PKSs use one set of enzymes repeatedly, while Type 2 PKSs use a set of enzymes every cycle Signup and view all the answers

What is the advantage of modular type I PKSs over Type 1 PKSs?

They can be reprogrammed for each cycle Signup and view all the answers

What is the function of KR, KS-a, KS-b, ACP, and Cyclase in PKS clusters?

They load acetyl starter and malonyl extender Signup and view all the answers

What determines beta-carbonyl processing in PKS clusters?

Reduction domains, KR, DH, and ER Signup and view all the answers

What kind of organic acids can function as starters in polyketide biosynthesis?

Many different organic acids Signup and view all the answers

What is the advantage of using branched versions of malonyl CoA as extenders in polyketide biosynthesis?

They introduce branches into the chain Signup and view all the answers

What is the difference between Type II aromatic polyketides and other polyketides?

Type II aromatic polyketides are built from multiple malonyl units and little or no b-ketone processing occurs Signup and view all the answers

What is the function of ACP in polyketide biosynthesis?

To self-load malonyl extender Signup and view all the answers

What is an example of a product that can be synthesized through polyketide biosynthesis?

Erythromycin Signup and view all the answers

What is the advantage of engineering available biosynthetic genes in polyketide biosynthesis?

To increase the yields of valuable compounds Signup and view all the answers