Pharm: Peptides [Cyclic polypeptides]

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

The cyclic polypeptides include the antimicrobial, ___________

Bacitracin

What is the ranking of cyclic polypeptides according to the rank in the WHO list of medically important antimicrobials?

Important antimicrobial

Describe the absorption properties of bacitracin.

There is no oral absorption, as it’s null.

What is the mechanism of action of bacitracin?

<p>Inhibition of cell wall synthesis (C)</p> Signup and view all the answers

Which bacteria is bacitracin active against?

<p>Gram positive bacteria (B)</p> Signup and view all the answers

Cyclic polypeptides are described as:

<p>Bactericidal (A)</p> Signup and view all the answers

Why is bacitracin not routinely included in susceptibility testing?

<p>It has a narrow spectrum of activity (D)</p> Signup and view all the answers

Oral formulations of bacitracin are labeled in which of the following species?

<p>Cattle and swine (A), Poultry and quails (B), Pheasant (C)</p> Signup and view all the answers

What is a key adverse effect of bacitracin when administered parenterally?

<p>Nephrotoxicity (B)</p> Signup and view all the answers

Why are penicillins and cephalosporins not commonly used in commercial ophthalmic formulations?

<p>There is a risk of contact sensitization (C)</p> Signup and view all the answers

Bacitracin is the third component of triple antibiotic ointment with neomycin and polymyxin B

<p>True (A)</p> Signup and view all the answers

Flashcards

Bacitracin

An antimicrobial cyclic polypeptide.

Bacitracin's WHO ranking

Categorized as an important antimicrobial.

Bacitracin absorption

Bacitracin is not absorbed orally.

Bacitracin's mechanism

Inhibits bacterial cell wall synthesis.

Signup and view all the flashcards

Bacitracin's targets

Effective against Gram-positive bacteria.

Signup and view all the flashcards

Cyclic polypeptides effect

Bactericidal (kills bacteria).

Signup and view all the flashcards

Bacitracin susceptibility testing

Due to its narrow spectrum of activity.

Signup and view all the flashcards

Bacitracin oral formulations

Cattle and swine.

Signup and view all the flashcards

Bacitracin's key adverse effect

Nephrotoxicity (kidney damage).

Signup and view all the flashcards

Penicillins/Cephalosporins in ophthalmic formulations

Risk of contact sensitization.

Signup and view all the flashcards

Bacitracin in triple antibiotic ointment

True

Signup and view all the flashcards

More Like This

Use Quizgecko on...
Open
Browser
Browser