Plavix: Flashcards on Classification and MOA

Questions and Answers

What is the classification of Plavix?

ACE Inhibitor

Platelet Inhibitor (correct)

Beta-blocker

Anticoagulant

What is the mechanism of action (MOA) of Plavix?

Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on each platelet.

Which conditions is Plavix indicated for?

Treatment of AMI patients (correct)

To treat hypertension

For headache relief

STEMI and NSTEMI cases (correct)

What are the other names for Plavix?

Clopidogrel bisulfate, Clopidogrel Signup and view all the answers

Common side effects of Plavix include _________.

bleeding, fever, liver problems, anaphylactic reactions, confusion, bronchospasms, increased creatinine levels, rash, hypotension, and assorted other complaints. Signup and view all the answers

What is a contraindication for using Plavix?

Active bleeding such as peptic ulcer or intracranial hemorrhage Signup and view all the answers

What special information should be considered for AMI patients taking Plavix?

Ask about history of active bleeding, recent stroke, known allergy to Plavix, check for allergies to ASA and eggs, avoid drug interactions with Omeprazole. Signup and view all the answers

How is Plavix typically administered?

Orally (PO) Signup and view all the answers

Study Notes

Plavix Overview

Plavix is classified as a platelet inhibitor, primarily used to reduce the risk of blood clots.

Mechanism of Action (MOA)

Clopidogrel, the active ingredient in Plavix, irreversibly binds to P2Y12 ADP receptors on platelets.
This binding inhibits platelet activation and aggregation, essential for blood clot formation.

Indications for Use

Indicated for treatment in acute myocardial infarction (AMI) patients.
Effective in both STEMI (ST-Elevation Myocardial Infarction) and NSTEMI (Non-ST-Elevation Myocardial Infarction) cases.
Used for patients with recent cerebrovascular accidents (CVA) and peripheral arterial disease.

Alternative Names

Commonly known as Clopidogrel bisulfate or simply Clopidogrel.

Side Effects

Potential side effects include various forms of bleeding, which can be fatal.
Other possible adverse effects: fever, liver issues, allergic reactions, confusion, bronchospasms, elevated creatinine levels, rashes, and hypotension.

Contraindications

Should not be used in patients with active bleeding conditions, such as peptic ulcers or intracranial hemorrhage.
Contraindicated in individuals with known hypersensitivity to Clopidogrel.

Special Considerations

Ask AMI patients about history of active bleeding, recent strokes, and allergies to Plavix, ASA, or eggs.
Avoid drug interactions with Omeprazole (Prilosec) and monitor use with NSAIDs and Warfarin due to bleeding risk.
Pregnancy category B; consult with an emergency medicine doctor for nursing mothers.
Safety and efficacy in pediatric patients have not been established.

Dosage and Administration

Administered orally, with a common initial dose of 600 mg as per physician orders.
Available in tablet forms of 75 mg and 300 mg.

Description

This quiz focuses on the essential flashcards related to Plavix, highlighting its classification as a platelet inhibitor and the mechanism of action (MOA) of clopidogrel. Learn about the drug's indications and vital functions in preventing clot formation. Perfect for students and healthcare professionals looking to reinforce their knowledge on pharmacology.