Platelet Testing and Storage Requirements in Blood Banks

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Questions and Answers

What is the purpose of adding dimethyl sulfoxide (DMSO) to platelets before freezing?

To extend the storage time of platelets (correct)

To prevent bacterial contamination

To remove pathogens from platelets

To improve platelet function

Which organization first introduced a requirement to screen platelets for possible bacterial contamination?

AABB

FROZEN PLATELETS

CAP (correct)

FDA

What is the purpose of centrifuging thawed platelets before transfusion?

To remove cryopreservative DMSO (correct)

To improve platelet viability

To reduce the level of pathogens

To enhance platelet function

What is an area of research and development mentioned related to platelet preparation and preservation?

Improving platelet additive solutions Signup and view all the answers

What is the typical in vivo recovery rate of platelets after transfusion?

33% Signup and view all the answers

What does B.B. King's quote 'THE BEAUTIFUL THING ABOUT LEARNING IS THAT NO ONE CAN TAKE IT AWAY FROM YOU' suggest?

Learning is a valuable asset Signup and view all the answers

What factor determines the storage duration of a unit of whole blood-prepared RBCs?

Type of anticoagulant preservative solution used Signup and view all the answers

What is a key requirement by the FDA for post-transfusion RBC survival?

Free hemoglobin less than 1% of the total hemoglobin Signup and view all the answers

How is RBC viability measured following transfusion?

By the 24-hour post-transfusion RBC survival rate Signup and view all the answers

What is the primary purpose of storing blood components between 1°C and 6°C?

To increase RBC viability Signup and view all the answers

What is an essential criterion for maintaining viability in stored blood components?

Blood stored in frozen state Signup and view all the answers

What determines the number of days blood components are stored for?

Preservative solution(s) utilized Signup and view all the answers

What is the purpose of anticoagulant preservative solutions in blood banking?

To add to RBCs after removal of plasma to prevent clotting Signup and view all the answers

Which of the following additive solutions contains citrate and phosphate?

Nutricel (AS-3) Signup and view all the answers

What are the main components found in all additive solutions for RBCs?

Saline, adenine, and glucose Signup and view all the answers

What is the temperature range for storing frozen RBCs before thawing and transfusion?

-70°C to -80°C Signup and view all the answers

Which of the following additive solutions is primarily used for autologous units and rare blood types storage?

Nutricel (AS-3) Signup and view all the answers

What is the FDA-approved storage period for packed RBCs treated with the additive solutions?

42 days Signup and view all the answers

Study Notes

CAP and AABB introduced requirements for screening platelets for bacterial contamination in 2002 and 2004 respectively.
Frozen platelets collected by apheresis are preserved with dimethyl sulfoxide (DMSO) and can be stored for up to 2 years.
Research and development in platelet preparation include better additive solutions, reduction of pathogens, platelet substitutes, new storage approaches, and cryopreservation methods.
Anticoagulant preservative solutions like Adsol (AS-1), Nutricel (AS-3), Optisol (AS-5), SOLX (AS-7) are used with RBCs and contain saline, adenine, glucose, and additional components like mannitol or citrate.
Red blood cell freezing involves the addition of glycerol for autologous transfusion and rare blood types, with two concentrations (40% and 20%) used for freezing RBCs stored for up to 10 years before transfusion.

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Description

Learn about the requirements for testing platelets for bacterial contamination and the storage process in blood banks. Understand the use of cryopreservative dimethyl sulfoxide (DMSO) and the steps involved in preparing frozen platelets for transfusion.