Podcast
Questions and Answers
What is the primary function of dopamine agonists in relation to prolactin levels?
What is the primary function of dopamine agonists in relation to prolactin levels?
- Stimulate growth hormone release
- Increase prolactin secretion
- Mimic somatostatin activity
- Decrease prolactin secretion (correct)
What effect does somatostatin analogues have on pituitary gland tumors?
What effect does somatostatin analogues have on pituitary gland tumors?
- Enhance prolactin production
- Increase hormone production
- Stimulate tumor growth
- Inhibit hormone secretion (correct)
Which drug is a synthetic form of growth hormone used to stimulate cell growth?
Which drug is a synthetic form of growth hormone used to stimulate cell growth?
- Ganirelix
- Somatropin (correct)
- Octreotide
- Cosyntropin
What role does cosyntropin play in clinical diagnosis?
What role does cosyntropin play in clinical diagnosis?
What is the mechanism of action of leuprolide?
What is the mechanism of action of leuprolide?
Which medication is primarily used to treat hyperprolactinemia?
Which medication is primarily used to treat hyperprolactinemia?
What is the therapeutic effect of posterior pituitary drugs?
What is the therapeutic effect of posterior pituitary drugs?
What is the main function of gonadotropin antagonists like ganirelix?
What is the main function of gonadotropin antagonists like ganirelix?
Flashcards
Dopamine Agonists
Dopamine Agonists
Mimic dopamine to reduce prolactin (PRL) production by the pituitary gland.
Somatostatin Analogues
Somatostatin Analogues
Reduce the release of hormones from pituitary tumors.
Posterior Pituitary Hormones
Posterior Pituitary Hormones
Increase water reabsorption by the kidneys and stimulate GI tract.
GH Agonists (Somatropin)
GH Agonists (Somatropin)
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GH Antagonists (Octreotide)
GH Antagonists (Octreotide)
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PRL Inhibitors (Dopamine Agonists)
PRL Inhibitors (Dopamine Agonists)
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TSH Agonists (Recombinant TSH)
TSH Agonists (Recombinant TSH)
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Gonadotropin Agonist (Leuprolide)
Gonadotropin Agonist (Leuprolide)
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Study Notes
Pituitary Drug Types and Mechanisms
- Dopamine Agonists: Mimic dopamine to reduce prolactin (PRL) production by the pituitary.
- Somatostatin Analogues: Reduce hormone secretion from pituitary tumors.
- Posterior Pituitary Hormones: Increase water reabsorption in kidneys by increasing water permeability in distal tubules and collecting ducts; also directly stimulate GI tract smooth muscle, causing peristalsis and vasoconstriction.
Growth Hormone (GH) Drugs
- GH Agonists (Somatropin): Synthetic GH, stimulating liver production of Insulin-like Growth Factor 1 (IGF-1). IGF-1 promotes cell growth, protein synthesis, and bone growth.
- GH Antagonists (Octreotide): Synthetic somatostatin analogues. These bind to somatostatin receptors on pituitary cells to suppress GH secretion.
Corticotropin Agonists
- Cosyntropin: Synthetic ACTH analogue used to diagnose adrenal insufficiency. It stimulates adrenal gland response to evaluate cortisol output.
Prolactin Inhibitors
- Dopamine Agonists (e.g., Bromocriptine): Act on dopamine receptors in the anterior pituitary, inhibiting prolactin secretion. Used to treat hyperprolactinemia and prolactinomas.
Thyroid Stimulating Hormone (TSH) Agonists
- Recombinant TSH: Stimulates thyroid gland to produce T3 and T4, used in specific clinical scenarios, such as thyroid cancer diagnosis and management, stimulating the thyroid without affecting endogenous hormone production.
Gonadotropin Agonists
- Leuprolide: Synthetic GnRH analogues. In pulsatile administration, stimulates anterior pituitary LH and FSH production, regulating reproductive functions. Clinically used for prostate cancer, endometriosis, and precocious puberty treatment.
Gonadotropin Antagonists
- Ganirelix: Blocks gonadotropin receptors in the pituitary, preventing LH and FSH secretion. Commonly used to control ovarian hyperstimulation in fertility treatments and prevent premature ovulation.
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Description
Explore the various drug types and mechanisms related to the pituitary gland in this quiz. Delve into the roles of dopamine agonists, somatostatin analogues, growth hormone drugs, and corticotropin agonists. Test your knowledge on how these medications affect hormone production and action in the body.
