12 Questions
What is the second most common age-related neurodegenerative disease?
Parkinson's disease
Who first described the cardinal clinical features of Parkinson's disease?
James Parkinson
Approximately how many people worldwide are estimated to have Parkinson's disease?
5 million
What is the mean age of onset for Parkinson's disease?
60 years
Which of the following is NOT listed as a cardinal clinical feature of Parkinson's disease?
Seizures
How is the lifetime risk of Parkinson's disease different between men and women?
Higher in men than women
What is the hallmark pathological feature of Parkinson's disease?
Degeneration of dopaminergic neurons in the substantia nigra pars compacta
What are the proteinaceous inclusions found in Parkinson's disease called?
Lewy bodies and Lewy neurites
Which brain regions are affected by non-dopaminergic neurodegeneration in Parkinson's disease?
Nucleus basalis of Meynert, locus coeruleus, and raphe nuclei
According to the Braak staging hypothesis, where does Lewy pathology begin in Parkinson's disease?
Peripheral autonomic nervous system, olfactory system, and lower brainstem
Which of the following is considered an early premotor symptom of Parkinson's disease?
Anosmia (loss of smell)
Why is it important to accurately define a premotor stage of Parkinson's disease?
To initiate disease-modifying treatment at the earliest possible stage
Learn about the visual and endocrinologic symptoms associated with pituitary adenomas, including microadenomas. Understand the age-related incidence and common presentations of pituitary adenomas.
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