Podcast
Questions and Answers
What is the size of the diameter of picornaviruses?
What is the size of the diameter of picornaviruses?
- ~50nm
- ~70nm
- ~30nm (correct)
- ~20nm
How many copies of VP4 are present in the mature virion of picornaviruses?
How many copies of VP4 are present in the mature virion of picornaviruses?
- 45
- 90
- 60 (correct)
- 30
What is the function of the internal ribosome entry site (IRES) present in picornavirus RNA?
What is the function of the internal ribosome entry site (IRES) present in picornavirus RNA?
- Assist in viral assembly
- Facilitate viral entry into host cells
- Promote viral replication
- Allow initiation of translation without having a 5’ cap (correct)
What is covalently bound to the 5’ end of picornavirus RNA?
What is covalently bound to the 5’ end of picornavirus RNA?
What is the function of the pyrimidine-rich track located 20-15 nucleotides from AUG in picornavirus RNA?
What is the function of the pyrimidine-rich track located 20-15 nucleotides from AUG in picornavirus RNA?
What is the role of VP4 in mature picornavirus virions?
What is the role of VP4 in mature picornavirus virions?
What is covalently bound to the 5’ end of picornavirus RNA?
What is covalently bound to the 5’ end of picornavirus RNA?
What is the function of the internal ribosome entry site (IRES) in picornavirus RNA?
What is the function of the internal ribosome entry site (IRES) in picornavirus RNA?
What is the mechanism by which picornavirus infection promotes its own translation in host cells?
What is the mechanism by which picornavirus infection promotes its own translation in host cells?
What is the role of VPg in the replication of picornavirus RNAs?
What is the role of VPg in the replication of picornavirus RNAs?
How are newly synthesized virions released from the host cell?
How are newly synthesized virions released from the host cell?
What is the main consequence of picornavirus infection on host cell macromolecular functions?
What is the main consequence of picornavirus infection on host cell macromolecular functions?
What is the role of eukaryotic initiation factors (eIFs) eIF-4A, eIF-4E, and eIF-4G in cellular translation?
What is the role of eukaryotic initiation factors (eIFs) eIF-4A, eIF-4E, and eIF-4G in cellular translation?
Which cellular process does Picornavirus infection induce in host cells?
Which cellular process does Picornavirus infection induce in host cells?
What is the size of the diameter of picornaviruses?
What is the size of the diameter of picornaviruses?
What is covalently bound to the 5’ end of picornavirus RNA?
What is covalently bound to the 5’ end of picornavirus RNA?
What is the function of the internal ribosome entry site (IRES) in picornavirus RNA?
What is the function of the internal ribosome entry site (IRES) in picornavirus RNA?
What is the role of VP4 in mature picornavirus virions?
What is the role of VP4 in mature picornavirus virions?
What is the role of VPg in the replication of picornavirus RNAs?
What is the role of VPg in the replication of picornavirus RNAs?
What is the function of the internal ribosome entry site (IRES) present in picornavirus RNA?
What is the function of the internal ribosome entry site (IRES) present in picornavirus RNA?
What is covalently bound to the 5’ end of picornavirus RNA?
What is covalently bound to the 5’ end of picornavirus RNA?
What is the main consequence of picornavirus infection on host cell macromolecular functions?
What is the main consequence of picornavirus infection on host cell macromolecular functions?
How are newly synthesized virions released from the host cell?
How are newly synthesized virions released from the host cell?
What is the mechanism by which picornavirus infection promotes its own translation in host cells?
What is the mechanism by which picornavirus infection promotes its own translation in host cells?
What is the function of eukaryotic initiation factors (eIFs) eIF-4A, eIF-4E, and eIF-4G in cellular translation?
What is the function of eukaryotic initiation factors (eIFs) eIF-4A, eIF-4E, and eIF-4G in cellular translation?
What is the size of the diameter of picornaviruses?
What is the size of the diameter of picornaviruses?
What is the role of VP4 in mature picornavirus virions?
What is the role of VP4 in mature picornavirus virions?
Which cellular process does Picornavirus infection induce in host cells?
Which cellular process does Picornavirus infection induce in host cells?
What is the function of the pyrimidine-rich track located 20-15 nucleotides from AUG in picornavirus RNA?
What is the function of the pyrimidine-rich track located 20-15 nucleotides from AUG in picornavirus RNA?
What is the main consequence of Picornavirus infection on host cell macromolecular functions?
What is the main consequence of Picornavirus infection on host cell macromolecular functions?
What is covalently bound to uridine residues to prime RNA synthesis in Picornavirus replication?
What is covalently bound to uridine residues to prime RNA synthesis in Picornavirus replication?
What is the role of the 40S ribosomal subunit in cellular translation?
What is the role of the 40S ribosomal subunit in cellular translation?
Which cellular process does Picornavirus infection induce in host cells?
Which cellular process does Picornavirus infection induce in host cells?
What is the mechanism by which newly synthesized virions are released from the host cell by Picornavirus?
What is the mechanism by which newly synthesized virions are released from the host cell by Picornavirus?
Study Notes
Picornavirus Structure and Function
- The diameter of picornaviruses is approximately 25-30 nanometers.
- There are 60 copies of VP4 present in the mature virion of picornaviruses.
- The internal ribosome entry site (IRES) present in picornavirus RNA facilitates the translation of viral RNA by allowing the ribosome to bind directly to the RNA, bypassing the need for a cap structure.
- VPg (a protein) is covalently bound to the 5’ end of picornavirus RNA.
Picornavirus Replication and Translation
- The pyrimidine-rich track located 20-15 nucleotides from AUG in picornavirus RNA serves as a binding site for the 40S ribosomal subunit, facilitating translation initiation.
- VP4 plays a crucial role in the formation of mature picornavirus virions.
- VPg is essential for the replication of picornavirus RNAs, as it acts as a primer for RNA synthesis.
- Picornavirus infection promotes its own translation in host cells by inducing the phosphorylation of eIF-4E, which leads to the inhibition of cellular translation and the redirection of the translation machinery to viral RNA.
Host Cell Interactions
- Newly synthesized virions are released from the host cell through the lysis of the cell.
- The main consequence of picornavirus infection on host cell macromolecular functions is the shutoff of cellular translation, allowing the virus to hijack the host cell's translation machinery.
- Picornavirus infection induces autophagy in host cells, which is a cellular process that involves the degradation of cellular components.
- Eukaryotic initiation factors (eIFs) eIF-4A, eIF-4E, and eIF-4G play a crucial role in cellular translation, as they facilitate the initiation of translation.
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Description
Test your knowledge of the structure and genome of picornaviruses, including their RNA genome, capsid composition, and binding to cellular receptors.
