PC 2: Flow Down Gradient
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Questions and Answers

According to the Nernst potential equation, what factors does it account for?

  • The charge of the particle
  • Diffusional forces and electrical fields
  • The ratio of the particles concentration intracellular:extracellular
  • Distribution of ions close to either side of the membrane (correct)

What does the Nernst potential equation not include?

  • Flow of ions (current)
  • Resistance of the membrane to flow
  • Both A and B (correct)
  • None of the above

Why is there an unequal distribution of sodium and potassium across the membrane?

  • Because of the ratio of the particles concentration intracellular:extracellular
  • Because of the Nernst potential
  • Because of the charge of the particles
  • All of the above (correct)

Why is it helpful to understand Nernst potentials?

<p>All of the above (D)</p> Signup and view all the answers

Why is the membrane potential of a neuron close to, but not the same, as the equilibrium (Nernst) potential for potassium?

<p>Because of the Goldman Field equation (B)</p> Signup and view all the answers

In Case 1, which clinical features are less likely to be due to vascular changes in Mary's feet?

<p>15 seconds capillary refill time on the right great toe (D)</p> Signup and view all the answers

In Case 2, what aspect(s) of Robert's medical history best explain his foot swelling?

<p>NYHA stage II heart failure (C)</p> Signup and view all the answers

According to the text, what problems do most patients with heart failure develop?

<p>All of the above (D)</p> Signup and view all the answers

According to the text, which equation describes the movement of charged particles across a membrane based on electrostatic forces?

<p>Nernst potential (C)</p> Signup and view all the answers

In which situations does diffusion and hydrostatic pressure act together to facilitate filtration through a capillary?

<p>Filtration through a capillary (D)</p> Signup and view all the answers

Which equation describes the balance of a particle moving into or out of a cell, assuming it can cross the membrane?

<p>Nernst equation (B)</p> Signup and view all the answers

What is the purpose of a capillary in physiology?

<p>To transport substances to and from tissues (B)</p> Signup and view all the answers

Which forces are difficult to measure experimentally?

<p>Starling forces (A)</p> Signup and view all the answers

Which equation describes the movement of dissolved particles across a membrane based on their concentration gradient?

<p>Fick’s law (A)</p> Signup and view all the answers

What does the Nernst equation tell us about the movement of charged particles across a membrane?

<p>The direction of particle movement (A)</p> Signup and view all the answers

Which equation describes the flow of a substance through a capillary?

<p>Poiseuille’s law (A)</p> Signup and view all the answers

Which forces can "pull" or "push" the same substance in opposite directions in physiology?

<p>Starling forces (A)</p> Signup and view all the answers

What does the term 'flux' describe in physiology?

<p>Flow along a defined membrane surface area (B)</p> Signup and view all the answers

Which equation describes the movement of fluid through a system from point A to point B?

<p>Poiseuille's law (A)</p> Signup and view all the answers

What is the driving force for the flow of a substance from point A to point B?

<p>Energy gradient (B)</p> Signup and view all the answers

What is the relationship between the size of the energy gradient and the amount of flow?

<p>Directly related (C)</p> Signup and view all the answers

Which equation describes the movement of charged particles across a membrane based on electrostatic forces?

<p>Nernst potential equation (B)</p> Signup and view all the answers

What is the purpose of a capillary in physiology?

<p>To facilitate fluid flow (A)</p> Signup and view all the answers

Which physico-chemical law is most relevant for understanding the movement of charged particles across a membrane?

<p>Ohm's law (D)</p> Signup and view all the answers

According to Fick's law, what factors affect the rate of diffusion across a membrane?

<p>Concentration gradient and surface area (D)</p> Signup and view all the answers

What does Ohm's law state about the relationship between current, voltage, and resistance?

<p>Current is directly proportional to resistance and directly proportional to voltage (A)</p> Signup and view all the answers

What does the Nernst potential equation describe?

<p>The movement of charged particles across a membrane based on their concentration gradient (A)</p> Signup and view all the answers

What is the purpose of a capillary in physiology?

<p>To facilitate the exchange of oxygen and carbon dioxide between the blood and tissues (B)</p> Signup and view all the answers

Which of the following best explains Robert's foot swelling in Case 2?

<p>Decreased cardiac output (C)</p> Signup and view all the answers

What is the most likely cause of Robert's shortness of breath in Case 2?

<p>Increased respiratory rate (D)</p> Signup and view all the answers

Which of the following is a consequence of impaired 'forward-flow' in heart failure?

<p>Impaired function of the kidneys (A)</p> Signup and view all the answers

What happens to blood in heart failure due to 'fluid backup'?

<p>It backs up in the venous system (B)</p> Signup and view all the answers

According to Fick's law, the rate of diffusion is affected by various parameters. Which of the following is NOT one of those parameters?

<p>Electrostatic pressure gradient (A)</p> Signup and view all the answers

According to Poiseuille's law, which of the following is the most important determinant of resistance in a vessel?

<p>Cross-sectional size of the vessel (radius) (B)</p> Signup and view all the answers

Which of the following is NOT a process in the body that depends on the flow of a substance down a gradient?

<p>Na+/K+ pump (A)</p> Signup and view all the answers

According to Pouiseille's law, what happens to the flow when the radius of a tube/vessel decreases by half?

<p>The flow decreases by a factor of 4 (A)</p> Signup and view all the answers

Which of the following is a factor that can affect the flow/flux of substances through capillaries?

<p>Solubility of the substance (D)</p> Signup and view all the answers

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