Physiological Models of Drug Absorption

The primary advantage of PBPK models is their ability to extrapolate drug absorption processes to different populations and conditions.

PBPK models use scaled drug-specific parameters to quantitatively predict plasma and tissue concentration-time profiles after oral administration.

PBPK models can be applied to both healthy volunteers and diseased populations by adjusting for relevant physiological properties.

<p>Scaled drug-specific parameters are crucial because they enable the model to accurately reflect the pharmacokinetics of specific drugs.</p> Signup and view all the answers

<p>PBPK modeling enhances drug development by providing insights into how a drug's absorption may differ across populations, aiding in risk assessment and dosing strategies.</p> Signup and view all the answers

<p>Key components include absorption scale factors, transit times, pH assignments, compartment geometries, and pharmacokinetic parameters.</p> Signup and view all the answers

<p>The nine compartments represent the five segments of the GI tract, allowing simulation of fluid transit and absorption processes.</p> Signup and view all the answers

<p>Processes include transit of fluid, gastric secretion, biliary and pancreatic secretions, and absorption of fluid.</p> Signup and view all the answers

<p>Dissolved compounds can be absorbed directly across the epithelium following their dissolution in the fluid content.</p> Signup and view all the answers

<p>Peristaltic motion simulates the movement of fluid through compartments, facilitating the transit and absorption of compounds.</p> Signup and view all the answers