Physiologic vs. Pathologic Neutrophilia

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What are the causes of physiologic/pseudoneutrophilia?

Exercise, stress, pain, pregnancy

How does pathologic neutrophilia differ from physiologic/pseudoneutrophilia?

Neutrophils leave the circulating pool, enter the marginating pool, and then move to the tissues in response to tissue damage in pathologic neutrophilia.

What is the characteristic of Neutrophilic leukemoid reaction (NLR)?

Blood picture mimics that seen in chronic myelogenous leukemia.

What is the range of WBC count increase in Neutrophilic leukemoid reaction (NLR)?

Between 50.0 and 100.0 X 109/L

What is the response of bone marrow in pathologic neutrophilia?

Bone marrow increases production of neutrophils to replenish reserves.

What is a characteristic feature of eosinophilia in terms of its association with chronic myelogenous leukemia?

Eosinophilia is associated with chronic myelogenous leukemia, including early maturation stages.

What is the distinguishing feature between Chronic Myelogenous Leukemia and Leukemoid Reaction in terms of leukocyte alkaline phosphatase score?

Leukemoid Reaction has a markedly increased leukocyte alkaline phosphatase score, while Chronic Myelogenous Leukemia has a markedly decreased score.

What is the significance of basophilia in relation to Type I hypersensitivity reactions?

Basophilia is associated with Type I hypersensitivity reactions.

What causes a decrease in the absolute number of eosinophils resulting in eosinopenia?

Eosinopenia can be seen in acute inflammation and inflammatory reactions that cause the release of glucocorticosteroids and epinephrine.

What is the functional abnormality seen in Chronic Granulomatous Disease (CGD) affecting neutrophils?

Chronic Granulomatous Disease (CGD) results in a functional abnormality of neutrophils due to enzyme deficiency that inhibits degranulation.

Learn about the differences between physiologic and pathologic neutrophilia. Understand how shifts in neutrophil pools can cause temporary increases in the total white blood cell count. Explore the causes and characteristics of each type of neutrophilia.

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