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Questions and Answers
Which of the following organs is considered a highly perfused organ for drug distribution?
Which of the following organs is considered a highly perfused organ for drug distribution?
- Skeleton
- Adipose tissue
- Lung (correct)
- Spleen
What is the distribution equilibrium of mepacrine in the liver compared to plasma?
What is the distribution equilibrium of mepacrine in the liver compared to plasma?
- 9,000/1
- 3/1
- 21,000/1 (correct)
- 5,000/1
Which barrier is responsible for restricting the distribution of drugs to the brain?
Which barrier is responsible for restricting the distribution of drugs to the brain?
- Blood-brain barrier (correct)
- Simple cell membrane barrier
- Blood-placental barrier
- Tumor cell membrane barrier
What factor affects the cellular distribution of phenobarbital?
What factor affects the cellular distribution of phenobarbital?
What is the effect of abnormal cellular proliferation on the vascular supply to cancer tissue?
What is the effect of abnormal cellular proliferation on the vascular supply to cancer tissue?
What property allows lipid soluble drugs to permeate through the lipid membrane for cellular distribution?
What property allows lipid soluble drugs to permeate through the lipid membrane for cellular distribution?
Which factor affects the distribution of drugs to the CNS by making capillaries in the brain less permeable to water-soluble substances?
Which factor affects the distribution of drugs to the CNS by making capillaries in the brain less permeable to water-soluble substances?
Which drug can penetrate the blood-brain barrier rapidly due to its high partition coefficient?
Which drug can penetrate the blood-brain barrier rapidly due to its high partition coefficient?
Why has giving dopamine as a replacement therapy for Parkinsonism failed?
Why has giving dopamine as a replacement therapy for Parkinsonism failed?
Why are tetracycline and penicillin not suitable for prophylaxis in meningitis?
Why are tetracycline and penicillin not suitable for prophylaxis in meningitis?
What affects placental distribution of drugs?
What affects placental distribution of drugs?
Which drugs must be taken into consideration during pregnancy due to their potential effects on the fetus?
Which drugs must be taken into consideration during pregnancy due to their potential effects on the fetus?
What is the main plasma protein involved in drug binding process and which type of drugs does it bind more with?
What is the main plasma protein involved in drug binding process and which type of drugs does it bind more with?
What does plasma protein binding do that influences the duration of action of drugs?
What does plasma protein binding do that influences the duration of action of drugs?
Which drug has a high plasma protein binding of 98%?
Which drug has a high plasma protein binding of 98%?
What type of drugs does globulin mainly bind with?
What type of drugs does globulin mainly bind with?
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