Drug Distribution in Physiology Lecture 3
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Questions and Answers

Which of the following organs is considered a highly perfused organ for drug distribution?

  • Skeleton
  • Adipose tissue
  • Lung (correct)
  • Spleen
  • What is the distribution equilibrium of mepacrine in the liver compared to plasma?

  • 9,000/1
  • 3/1
  • 21,000/1 (correct)
  • 5,000/1
  • Which barrier is responsible for restricting the distribution of drugs to the brain?

  • Blood-brain barrier (correct)
  • Simple cell membrane barrier
  • Blood-placental barrier
  • Tumor cell membrane barrier
  • What factor affects the cellular distribution of phenobarbital?

    <p>pH of extracellular fluid</p> Signup and view all the answers

    What is the effect of abnormal cellular proliferation on the vascular supply to cancer tissue?

    <p>Decreases vascular supply</p> Signup and view all the answers

    What property allows lipid soluble drugs to permeate through the lipid membrane for cellular distribution?

    <p>Small size of molecules</p> Signup and view all the answers

    Which factor affects the distribution of drugs to the CNS by making capillaries in the brain less permeable to water-soluble substances?

    <p>Cellular lipid sheath (BBB)</p> Signup and view all the answers

    Which drug can penetrate the blood-brain barrier rapidly due to its high partition coefficient?

    <p>Thiopental</p> Signup and view all the answers

    Why has giving dopamine as a replacement therapy for Parkinsonism failed?

    <p>It is water-soluble and cannot penetrate BBB</p> Signup and view all the answers

    Why are tetracycline and penicillin not suitable for prophylaxis in meningitis?

    <p>They are highly ionized in the blood</p> Signup and view all the answers

    What affects placental distribution of drugs?

    <p>pH of maternal and fetal blood</p> Signup and view all the answers

    Which drugs must be taken into consideration during pregnancy due to their potential effects on the fetus?

    <p>Alcohol and nicotine</p> Signup and view all the answers

    What is the main plasma protein involved in drug binding process and which type of drugs does it bind more with?

    <p>Albumin - acidic drugs</p> Signup and view all the answers

    What does plasma protein binding do that influences the duration of action of drugs?

    <p>Increases half-life and duration of action</p> Signup and view all the answers

    Which drug has a high plasma protein binding of 98%?

    <p>Dicoumarol (Bishydroxycoumarin)</p> Signup and view all the answers

    What type of drugs does globulin mainly bind with?

    <p>Basic drugs</p> Signup and view all the answers

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