Phosphatidylinositol 3-Kinase Pathway Quiz
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Questions and Answers

What is the name of the serine-threonine-specific protein kinase that is a key participant in the PI3K/Akt pathway?

  • ERK
  • PI3K
  • mTOR (correct)
  • Ral

    • Which enzyme, when activated, phosphorylates several target proteins to regulate gene expression, cell survival, and translational processes?

  • mTOR
  • PI3K (correct)
  • ERK
  • Ral

    • What antibiotic is mTOR named after?

  • Rapamycin (correct)
  • Penicillin
  • Tetracycline
  • Streptomycin

    • Which inhibitor is being tested in various tumors and acts on mTOR to inhibit protein synthesis initiation?

    <p>Rapamycin</p> Signup and view all the answers

    What is the main mediator that reshapes the cytoskeleton through rearrangement by the Ral GTP complex?

    <p>Ral</p> Signup and view all the answers

    What pathway has an enhanced function detectable in about half of human tumors, underlining its medical significance?

    <p>PI3K pathway</p> Signup and view all the answers

    What is the initial substrate for the inositol phospholipid pathway?

    <p>Phosphatidylinositol bisphosphate (PIP2)</p> Signup and view all the answers

    Which enzyme catalyzes the hydrolysis of PIP2 in the inositol phospholipid pathway?

    <p>Phospholipase C</p> Signup and view all the answers

    What is the role of the Gq protein in the inositol phospholipid pathway?

    <p>It mediates the effect of the ligand-stimulated receptor on PLC-β isoenzymes</p> Signup and view all the answers

    What are the two secondary messengers produced by the hydrolysis of PIP2?

    <p>Inositol trisphosphate (IP3) and diacylglycerol (DAG)</p> Signup and view all the answers

    What is the role of inositol trisphosphate (IP3) in the inositol phospholipid pathway?

    <p>It opens Ca^{2+} channels in the endoplasmic reticulum membrane</p> Signup and view all the answers

    Which signaling pathway is not directly related to the inositol phospholipid pathway?

    <p>cAMP-dependent protein kinase A (PKA) pathway</p> Signup and view all the answers

    Which of the following statements about the phosphatidylinositol 3-kinase (PI3K) pathway is correct?

    <p>PI3K has a form that is activated via the Ras protein.</p> Signup and view all the answers

    Which enzyme is responsible for the inactivation of PIP3 molecules in the PI3K pathway?

    <p>PTEN (phosphatase and tensin)</p> Signup and view all the answers

    Which of the following proteins is a major enzyme in the PI3K pathway?

    <p>Protein kinase B (PKB)</p> Signup and view all the answers

    Which of the following statements about the Akt protein is correct?

    <p>Akt is a homologue of PKB and is an oncoprotein of tumor-causing RNA viruses.</p> Signup and view all the answers

    Which of the following pathways is directly involved in the PI3K pathway?

    <p>Inositol phospholipid pathway</p> Signup and view all the answers

    Which of the following statements about the PI3K pathway is correct?

    <p>Phosphorylated lipid molecules like PIP3 attract specific signaling proteins from the cytosol.</p> Signup and view all the answers

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