Podcast
Questions and Answers
What is the primary function of Flavin Monooxygenase (FMO) in Phase I biotransformation?
What is the primary function of Flavin Monooxygenase (FMO) in Phase I biotransformation?
- Reduction of xenobiotics
- N,S oxidation to give N-oxides and sulfoxides (correct)
- Hydrolysis of lipophilic drugs
- Conjugation of Phase I metabolites
What is the reactive oxidant in the reaction catalyzed by Flavin Monooxygenase (FMO)?
What is the reactive oxidant in the reaction catalyzed by Flavin Monooxygenase (FMO)?
- NADPH
- Oxygen
- Flavin hydroperoxide (correct)
- NAD+
Which enzyme is responsible for the oxidation of aldehydes to carboxylic acids?
Which enzyme is responsible for the oxidation of aldehydes to carboxylic acids?
- Esterases
- Flavin Monooxygenase (FMO)
- Aldehyde Dehydrogenase (ALDH) (correct)
- Alcohol Dehydrogenase (ADH)
What is the substrate characteristic of Alcohol Dehydrogenase (ADH) isoforms?
What is the substrate characteristic of Alcohol Dehydrogenase (ADH) isoforms?
What is the result of a genetic defect in Flavin Monooxygenase (FMO) in humans?
What is the result of a genetic defect in Flavin Monooxygenase (FMO) in humans?
What is the role of Aldehyde Dehydrogenase (ALDH) in the metabolism of Hydroxyzine?
What is the role of Aldehyde Dehydrogenase (ALDH) in the metabolism of Hydroxyzine?
What is the result of lipid oxidation in the body?
What is the result of lipid oxidation in the body?
Which enzyme is responsible for the majority of ethanol metabolism in humans?
Which enzyme is responsible for the majority of ethanol metabolism in humans?
What is the result of being homozygous for the ALDH2*2 allele?
What is the result of being homozygous for the ALDH2*2 allele?
What is the byproduct of ethanol metabolism that is then oxidized by aldehyde dehydrogenases?
What is the byproduct of ethanol metabolism that is then oxidized by aldehyde dehydrogenases?
What is the mechanism of aldehyde dehydrogenase action?
What is the mechanism of aldehyde dehydrogenase action?
What is the result of acetaldehyde accumulation in the body?
What is the result of acetaldehyde accumulation in the body?
