Pharyngeal Apparatus Development Quiz

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Questions and Answers

Which of the following anomalies refers to the absence or underdevelopment of the nose?

  • Choanal atresia
  • Nasal aplasia (correct)
  • Cleft nose
  • Nasal polyps

Choanal atresia is a condition that affects the structure of the lens.

False (B)

What is the primary palate responsible for forming?

Upper lip, philtrum, primary palate

The ________ are outpouchings of the forebrain that develop into the retina and optic nerve.

<p>optic vesicles</p> Signup and view all the answers

At what week does the development of the palate begin?

<p>6th week (B)</p> Signup and view all the answers

The lens vesicle differentiates into lens epithelium and lens fibers after the 8th week.

<p>True (A)</p> Signup and view all the answers

Match the following parts of the eye with their function or description:

<p>Optic vesicles = Give rise to retina and optic nerve Lens placode = Form the lens vesicle Retinal pigment epithelium = Outer layer of optic cup Neural retina = Inner layer of optic cup</p> Signup and view all the answers

The ___________ develops from the fusion of the maxillary prominences.

<p>secondary palate</p> Signup and view all the answers

When does the lens reach its adult size?

<p>At the ages of 5 - 6 (B)</p> Signup and view all the answers

The corneal stroma is formed from the ectoderm.

<p>False (B)</p> Signup and view all the answers

What begins the development of the choroid?

<p>The formation of optic cups</p> Signup and view all the answers

The iris develops from the anterior portion of the optic cup and forms two layers: the stroma and the ______.

<p>epithelium</p> Signup and view all the answers

At which weeks does the corneal endothelium start to form?

<p>7 - 8 weeks (C)</p> Signup and view all the answers

Match the following eye structures with their associated development timeline:

<p>Cornea = 5th - 6th week Choroid = 4th - 5th week Sclera = 4th - 5th week Iris = 3rd - 4th week</p> Signup and view all the answers

The sclera develops from the mesenchymal cells migrating around the optic cup.

<p>True (A)</p> Signup and view all the answers

What are the two layers into which the choroidal mesenchyme differentiates?

<p>Choriocapillaris and larger vessels</p> Signup and view all the answers

At what week of embryonic development does the cochlear duct complete its 2.5 turns?

<p>8th week (C)</p> Signup and view all the answers

The organ of Corti is formed from the merging of inner and outer epithelial ridges.

<p>True (A)</p> Signup and view all the answers

What structures arise from the flattened outpouchings of the otic vesicle during embryonic development?

<p>Semicircular canals</p> Signup and view all the answers

The ___ gives rise to the eustachian tube during the development of the middle ear.

<p>tubotympanic recess</p> Signup and view all the answers

Match the following anatomical structures with their corresponding development stages or features:

<p>Cochlear duct = 8th week Organ of Corti = 7th week Semicircular canals = 6th week Ossicles = 4th to 5th week</p> Signup and view all the answers

Which of the following is NOT considered an anomaly of the inner ear?

<p>Absence of tympanic cavity (A)</p> Signup and view all the answers

The middle ear development begins at the 5th week of embryonic development.

<p>False (B)</p> Signup and view all the answers

What are the three types of anomalies that can occur in the cochlea?

<p>Aplasia, Hypoplasia, Dysplasia</p> Signup and view all the answers

What does the first pharyngeal pouch give rise to?

<p>Middle ear and Eustachian tube (D)</p> Signup and view all the answers

The ventral portion of the third pouch becomes the inferior parathyroid gland.

<p>False (B)</p> Signup and view all the answers

Which muscle is associated with the second arch?

<p>Stylohyoid muscle</p> Signup and view all the answers

The dorsal portion of the fourth pouch becomes the __________ gland.

<p>superior parathyroid</p> Signup and view all the answers

Which of the following anomalies is characterized by the premature fusion of skull bones?

<p>Craniosynostosis (D)</p> Signup and view all the answers

Hemifacial Microsomia is also known for underdevelopment of both sides of the face.

<p>False (B)</p> Signup and view all the answers

Which muscles are derived from the fourth arch?

<p>Cricothyroid muscle (A)</p> Signup and view all the answers

What are the two prominent facial structures affected by Treacher Collins Syndrome?

<p>Facial bones and cheekbones</p> Signup and view all the answers

What do the second to fourth clefts primarily form during development?

<p>They fade as cells grow and contribute to the formation of primitive tonsils.</p> Signup and view all the answers

Match the arch with its corresponding structures or muscles:

<p>Second Arch = Stylohyoid muscle, stapedius muscle Third Arch = Stylopharyngeus muscle Fourth Arch = Levator palatini, Cricothyroid muscle Sixth Arch = Intrinsic muscles of the larynx</p> Signup and view all the answers

The development of the nose begins with the fusion of the medial nasal prominence to form the ______.

<p>frontal nasal prominence</p> Signup and view all the answers

Match the following anomalies with their characteristics:

<p>Cleft Lip and Palate = A gap in the upper lip and/or palate Craniosynostosis = Abnormal head shape due to fused skull bones Hemifacial Microsomia = Underdevelopment of one side of the face Treacher Collins Syndrome = Underdevelopment of facial bones</p> Signup and view all the answers

The part of the third pharyngeal pouch that becomes the __________ gland is the dorsal portion.

<p>inferior parathyroid</p> Signup and view all the answers

At what weeks do the cheek prominences begin to form during embryonic development?

<p>6-7 weeks (A)</p> Signup and view all the answers

The nasal septum begins to form in the 7th to 8th week of embryonic development.

<p>True (A)</p> Signup and view all the answers

During which weeks does the maxillary process contribute to the development of cheek prominences?

<p>8-10 weeks</p> Signup and view all the answers

What forms in the vitreous space between the lens and retina during the 6th to 7th week of embryonic development?

<p>Vitreous body (A)</p> Signup and view all the answers

The vitreous body consists of a solid structure that does not provide cushioning to the retina.

<p>False (B)</p> Signup and view all the answers

What is the term for the condition characterized by the absence of one or both eyes?

<p>Anophthalmia</p> Signup and view all the answers

The _______ forms the saccule and the cochlear duct during inner ear development.

<p>ventral component</p> Signup and view all the answers

Match each eye anomaly with its description:

<p>Microphthalmia = Small eyes Coloboma = Hole or defect in the iris, retina, or optic nerve Cataract = Clouding of the lens Keratoconus = Thinning and conical shape of the cornea</p> Signup and view all the answers

At what week does the eye continue to grow and refine its shape, completing the formation of the iris, pupil, and sclera?

<p>13th week (C)</p> Signup and view all the answers

Retinitis pigmentosa is a genetic disorder that affects the outer ear.

<p>False (B)</p> Signup and view all the answers

What condition involves the dislocation of the lens?

<p>Ectopia lentis</p> Signup and view all the answers

Flashcards

Craniosynostosis

Premature fusion of skull bones, leading to an abnormal head shape.

Cleft Lip and Palate

A congenital condition where the upper lip and/or palate have a gap.

Hemifacial Microsomia

Underdevelopment of one side of the face.

Treacher Collins Syndrome

Underdevelopment of facial bones, particularly the cheekbones.

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Development of Cheeks

The formation of the cheeks starts with the pharyngeal arches from the mesoderm.

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Development of Nose

Fusion of the medial nasal prominence forming the frontal nasal prominence, which will give rise to the nose.

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Formation of Nasal Pits

Invagination of nasal placodes to form nasal pits.

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Formation of Nasal Cavities

Separation and deepening of the nasal septum to form two nasal cavities.

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What does the second pharyngeal arch develop into?

The second pharyngeal arch gives rise to the muscles involved in facial expression and chewing. These include the stylohoid muscle, posterior belly of the digastric muscle, and stapedius muscle of the middle ear.

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What structures are formed from the third pharyngeal arch?

The third pharyngeal arch contributes to the hyoid bone and a single throat muscle called the stylopharyngeus.

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What muscles develop from the fourth pharyngeal arch?

The fourth pharyngeal arch develops into muscles involved in swallowing and vocalization. These include the levator palatini, pharyngeal constrictors, and cricothyroid muscles.

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What does the sixth pharyngeal arch form?

The sixth pharyngeal arch is responsible for the development of the rest of the intrinsic muscles of the larynx, which are crucial for voice production.

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What structures develop from the first pharyngeal pouch and cleft?

The first pharyngeal pouch develops into the middle ear and Eustachian tube, while the first pharyngeal cleft forms the external auditory meatus and ear drum.

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What happens to the second to fourth pharyngeal clefts?

The second to fourth pharyngeal clefts degenerate, while the cells from the second pouch form the primitive tonsils.

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What structures arise from the dorsal and ventral portions of the third pharyngeal pouch?

The dorsal portion of the third pharyngeal pouch develops into the inferior parathyroid gland, while the ventral portion becomes the primitive thymus.

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What do the dorsal and ventral portions of the fourth pharyngeal pouch develop into?

The dorsal portion of the fourth pharyngeal pouch forms the superior parathyroid gland. The ventral portion forms the ultimo-pharyngeal body, which contributes to the parafollicular/C-cells of the thyroid.

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Nasal Development (Week 12 onwards)

The development of the nose, starting from the 12th week after conception, involves the refinement and maturation of its structures, including the nasal passages, septum, and conchae.

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Cleft Nose

A congenital condition where there is a gap or groove in the nose.

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Nasal Aplasia

A birth defect where the nose is either absent or underdeveloped.

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Nasal Proboscis

A birth defect where a tubular structure protrudes from the nose.

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Choanal Atresia

A blockage of the nasal passages that is present at birth.

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Nasal Septal Deviation

A condition where the nasal septum is shifted to one side, causing breathing difficulties.

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Nasal Polyps

A condition where growths develop in the nasal passages, blocking airflow and causing discomfort.

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Primary Palate Development

The initial stage of palate development, occurring during the 6th to 7th week of gestation, involves the fusion of the medial nasal prominences.

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Vitreous Humor

A clear gel-like substance that fills the vitreous space, providing support and cushioning to the retina.

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Vitreous Fibers

Collagen fibers that are part of the vitreous body, adding structure and strength to the eye.

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Microphthalmia

A congenital condition where the eye is smaller than normal.

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Anophthalmia

The absence of one or both eyes, a rare birth defect.

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Coloboma

A gap or defect in the iris, retina, or optic nerve.

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Ptosis

Drooping of one or both eyelids, often caused by muscle weakness.

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Keratoconus

Thinning and conical shape of the cornea, causing distorted vision.

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Retinitis Pigmentosa

A genetic disorder causing progressive deterioration of the retina, leading to vision loss.

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What is the cornea?

The transparent, outer layer of the eye that helps focus light.

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How does the cornea develop?

The corneal epithelium, stroma, and endothelium form during the first 12 weeks of embryonic development, becoming more organized and structured.

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What is the choroid?

The choroid, located between the retina and sclera, develops from mesenchymal cells migrating between the RPE and sclera.

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How does the choroid develop?

The choroid differentiates into two layers: the choriocapillaris (capillary layer) and larger vessels, becoming more vascularized and organized during the first 12 weeks of development.

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What is the sclera?

The sclera, the white outer layer of the eye, develops from mesenchymal cells migrating around the optic cup.

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How does the sclera develop?

The scleral mesenchyme differentiates into scleral fibroblasts, which produce collagen, making the sclera more dense and organized during the first 12 weeks of development.

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What is the iris?

The iris, the colored part of the eye, develops from the anterior portion of the optic cup, forming two layers: the stroma and epithelium.

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How is the iris structured?

The stroma of the iris is derived from the mesenchyme, while the epithelium originates from the neuroectoderm.

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Cochlear Duct Development

The cochlear duct forms as a tubular outgrowth from the saccule, spiraling through the mesenchyme to complete 2.5 turns by the 8th week of development.

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Organ of Corti Development

Two epithelial ridges, inner and outer, develop in the cochlear duct at the 7th week. The inner ridge forms the spiral liumbus, while the outer ridge gives rise to the sensory hair cells.

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Semicircular Canal Development

Flattened outpouchings on the dorsal otic vesicle at the 6th week develop into three semicircular canals: superior, posterior, and lateral.

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Middle Ear Development (Early Stage)

The development of the middle ear begins with the formation of the first pharyngeal arch during the 4th week.

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Middle Ear Development (Pharyngeal Pouch)

During the 5th week, the endoderm-lined pharynx invaginates between the first and second pharyngeal arches to form the first pharyngeal pouch.

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Middle Ear Development (Differentiation)

By the 6th week, the first pharyngeal pouch differentiates into the proximal tubotympanic recess, which forms the eustachian tube, and the distal tympanic cavity, which develops into the middle ear cavity.

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Ossicle Development

Cartilage templates for the malleus, incus, and stapes are formed during the 6th week of embryonic development.

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Inner Ear Anomalies

Absence, underdevelopment, or abnormal development of the cochlea, semicircular canals, and other inner ear structures can occur.

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Study Notes

Pharyngeal Apparatus Development

  • Pharyngeal apparatus development begins during the 4th-6th week of embryonic development.
  • Six pharyngeal arches form in a craniocaudal arrangement.
  • Four pharyngeal clefts externally cover each arch.
  • Four pharyngeal pouches internally line each arch.
  • Each arch is innervated by a cranial nerve:
    • First arch: mandibular branch of trigeminal nerve (CN V3)
    • Second arch: facial nerve (CN VII)
    • Third arch: glossopharyngeal nerve (CN IX)
    • Fourth arch: superior laryngeal branch of vagus nerve (CN X)
    • Sixth arch: recurrent laryngeal branch of vagus nerve (CN X)
  • Muscles and bones originate from pharyngeal arches by the 6th-8th week.

Arch-Specific Structures

ARCH BONES MUSCLES
FIRST Mandible, Maxilla, Zygomatic, Temporal, Incus, Malleus Chewing muscles (Temporalis, Masseter, Pterygoids); Swallowing muscles (Tensor veli palatini, Mylohyoid, Anterior belly of Digastric)
SECOND Lesser horns, upper hyoid, Styloid process, Stapes Stylohyoid, Posterior belly of Digastric, Stapedius, Stylopharyngeus
THIRD Rest of hyoid Levator palatini, Pharyngeal constrictors, Cricothyroid
FOURTH
SIXTH Intrinsic muscles of larynx

Pharyngeal Pouches and Clefts

  • The 1st pharyngeal pouch and cleft contribute to middle ear formation.
  • The 1st pouch forms the internal auditory meatus (part of the middle ear).
  • The 1st cleft develops into the external auditory meatus (ear canal).
  • The 2nd-4th pouches and clefts contribute to the formation of tonsils and glands.

Pharyngeal Apparatus Anomalies

  • Pierre Robin sequence: underdevelopment of mandible and tongue
  • Treacher Collins syndrome: underdevelopment of zygomatic bone and mandible
  • Hemifacial microsomia: underdevelopment of mandible and surrounding tissues
  • Branchial cleft cysts/fistulas: abnormal development of 2nd pharyngeal cleft
  • Thymic hypoplasia: underdevelopment of thymus (3rd pouch)
  • Parathyroid gland abnormalities: abnormal development of the parathyroid glands (3rd & 4th pouches)

Face Development

  • Facial development begins during the 4th-5th week of embryonic development from facial prominences.
  • Frontonasal prominence, maxillary prominences, and mandibular prominences.
  • These prominences merge to form the upper lip, nose, and jaw by the 11th-12th week.

Face Anomalies

  • Cleft lip/palate: incomplete fusion of facial prominences
  • Craniosynostosis: premature fusion of skull bones
  • Hemifacial microsomia: underdevelopment of one side of the face
  • Treacher Collins syndrome: underdevelopment of facial bones.

Cheeks Development

  • Cheeks develop from the 1st & 2nd pharyngeal arches, primarily from the maxillary process, which forms a growth from the 1st arch.

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