30 Questions
What is the purpose of the subcoating in tablet manufacturing?
To round the edges and build up tablet size
What is the main function of smoothing in tablet manufacturing?
To remove imperfections in tablet surface
Which solution is typically used in the final syruping step of coloring tablets?
Dye-containing syrup
What is the primary purpose of polishing tablets in the manufacturing process?
To make the tablets shiny
Which ingredient is NOT commonly used in subcoating tablets?
Beeswax
What distinguishes the grossing syrup from other sugar syrups used in tablet manufacturing?
It has suspended particles
What can cause cracking, chipping, and splitting of sugar coatings on tablets?
Expansion of tablet cores
What is a common problem associated with non-drying sugar coatings?
Sugar inversion
What can cause uneven color in sugar-coated tablets?
Poor distribution of coating liquids
Which problem arises from residual moisture in sugar-coated tablets?
Formation of beads of perspiration
What is the result of tablet cores expanding in sugar-coated tablets?
Cracking of the coating
Why does the addition of a small quantity of polymer often help improve the structure integrity of sugar-coated tablets?
To strengthen the coating against cracking
What is the main purpose of press coating in tablet manufacturing?
To compact granular material around an already performed core
Which type of tablets must comply with the uniformity of mass test?
Film coated tablets
What is a challenge test done for enteric coated tablets?
Testing the tablets in acidic medium
Which factor contributes to the disadvantages of press coating?
Complexities of the mechanism in the compressing machine
What is the primary purpose of two steps of press coating with an inert middle layer?
To provide perfect separation between two ingredients
How long should immediate release film-coated tablets take to disintegrate?
30 minutes
What is the advantage of multiparticulates over conventional non-disintegrating tablets?
Multiparticulates are smaller in size, allowing for more consistent gastrointestinal transit.
How are drug loaded nonpareils typically prepared?
Extrusion/spheronization or rotor granulation methods are used.
Why are irregular granules difficult to coat uniformly?
Their shape does not allow for proper adhesion of the coating.
What happens if whole non-disintegrating tablets lodge in restriction within the gastrointestinal tract?
This can lead to ulcerative mucosal damage.
Why are multiparticulates less likely to have issues related to film failure or poor coating uniformity?
Because they have a smaller size and more uniform shape.
What is a common application of multiparticulates in dosage forms?
Extended or delayed release formulations.
What is the advantage of using fluidized bed coating over pan coating for multiparticulates?
Minimizes the risk of agglomeration
Which method involves tablets being coated by dipping them into a coating solution?
Dip coating
What materials are commonly used in hot melt coating for tablets with melting points between 55-65 degrees Celsius?
Synthetic monoglyceride and diglycerides
Which recent innovation allows a coated product to be about one-third smaller than an equivalent powder-filled capsule?
Gelatin-coated tablets
What advantage does gelatin coating provide in terms of swallowing the tablets?
Facilitates swallowing
Which method uses principles similar to those used in photocopying for tablet coating?
Electrostatic powder coating process
Learn about the tablet subcoating process, where sugar, gelatin, or acacia solutions are applied to tablets followed by the addition of bulking agents like calcium carbonate or talc. Discover how subsequent subcoats are applied to achieve the desired thickness.
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