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Questions and Answers
Size reduction involves the production of larger mass units from smaller mass units of the same material.
Size reduction involves the production of larger mass units from smaller mass units of the same material.
False (B)
Increasing the energy of impact in size reduction leads to larger particles becoming smaller in size and more numerous.
Increasing the energy of impact in size reduction leads to larger particles becoming smaller in size and more numerous.
True (A)
Size reduction has no impact on rates of dissolution, chemical reaction, mixing, extraction, drying, and absorption in pharmacy.
Size reduction has no impact on rates of dissolution, chemical reaction, mixing, extraction, drying, and absorption in pharmacy.
False (B)
According to the text, the size of the finer particles is not related to the internal structure of the material.
According to the text, the size of the finer particles is not related to the internal structure of the material.
The production of fine particles through size reduction only impacts oral administration, not topical or parenteral administration.
The production of fine particles through size reduction only impacts oral administration, not topical or parenteral administration.
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Study Notes
Size Reduction
- Size reduction involves producing smaller mass units from larger mass units of the same material.
Importance of Size Reduction in Pharmacy
- Size reduction enhances rates of: • dissolution • chemical reaction • mixing • extraction • drying • absorption
- This enhancement occurs in: • oral administration • topical application • parenteral administration
Theory of Size Reduction
- When a single particle is subjected to sudden impact and fractured, it yields: • few relatively large particles • a number of fine particles • relatively few particles of intermediate size
- If the energy of the impact is increased: • larger particles become smaller and more numerous • the number of fine particles increases appreciably, but their size does not change greatly
- The size of finer particles relates to the internal structure of the material
- The size of larger particles relates to the energy of impact
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