Pharmacotherapy IX (PHAR 9969): CNS Module Lecture 01-10-24 Antidepressants MOA
32 Questions
3 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the leading cause of disability in the U.S. for ages 15-44?

  • Depression (correct)
  • Schizophrenia
  • Anxiety disorders
  • Bipolar disorder
  • What is the lifetime prevalence of depression in women compared to men?

  • Twice the rate (correct)
  • Three times higher
  • Half the rate
  • Equal
  • What percentage of depressed people are likely to commit suicide?

  • 20%
  • 15% (correct)
  • 5%
  • 10%
  • What is the total economic toll of depression in the U.S. annually?

    <p>$100 billion</p> Signup and view all the answers

    What is the Monoamine hypothesis related to?

    <p>Depression</p> Signup and view all the answers

    Which neurotransmitter system is discussed in the objectives related to depression?

    <p>Serotonergic system</p> Signup and view all the answers

    Which co-morbidities occur more frequently in women?

    <p>Anxiety disorders and eating disorders</p> Signup and view all the answers

    What do women respond better to in terms of treatment for depression?

    <p>Serotonin-selective reuptake inhibitors (SSRIs)</p> Signup and view all the answers

    What enzyme is responsible for metabolizing the neurotransmitter monoamine?

    <p>MAO</p> Signup and view all the answers

    Which neurotransmitter deficiency can cause depression?

    <p>Serotonin (5-HT)</p> Signup and view all the answers

    What is implicated in the alterations in the norepinephrine (NE) system in depression?

    <p>α2-adrenergic autoreceptors and decreased NE transporter binding sites</p> Signup and view all the answers

    What is associated with an increased risk of developing mood disorders?

    <p>Experiencing significant life events at an early age</p> Signup and view all the answers

    What is often disrupted in patients with depression?

    <p>Circadian rhythms</p> Signup and view all the answers

    What gets shorter as the night goes on in depressed patients?

    <p>REM periods</p> Signup and view all the answers

    "Stress-induced psychiatric disorders" involve which axis?

    <p>&quot;Hypothalamic-Pituitary-Adrenal (HPA)&quot; Axis</p> Signup and view all the answers

    Where are the CRH axons/terminals localized in human brain?

    <p>Locus Coeruleus and raphe n.</p> Signup and view all the answers

    What does the term 'neuraxis' refer to in the context of neuroanatomy?

    <p>A line beginning at the base of the spinal cord and ending at the front of the brain</p> Signup and view all the answers

    Which component is part of the peripheral nervous system (PNS) according to the text?

    <p>Sympathetic division</p> Signup and view all the answers

    What is the role of the somatic nervous system in the nervous system?

    <p>Controls voluntary muscles</p> Signup and view all the answers

    Which division of the autonomic system is responsible for 'rest and digest' functions?

    <p>Parasympathetic division</p> Signup and view all the answers

    Where are the soma of sensory afferent nerves located?

    <p>Dorsal root ganglia</p> Signup and view all the answers

    Which part of the nervous system includes the brain and spinal cord?

    <p>Central nervous system (CNS)</p> Signup and view all the answers

    Which division of the autonomic nervous system dominates during times of stress, excitement, and exertion?

    <p>Sympathetic division</p> Signup and view all the answers

    Where are the soma of efferent parasympathetic neurons located?

    <p>In the brain</p> Signup and view all the answers

    What is the function of the parasympathetic division of the autonomic nervous system?

    <p>Decrease respiration</p> Signup and view all the answers

    Which neurotransmitter is released by preganglionic sympathetic neurons?

    <p>Acetylcholine</p> Signup and view all the answers

    What do several cranial nerves innervate, making them part of the autonomic nervous system?

    <p>Glands and organs</p> Signup and view all the answers

    Which layer of tissue covers and protects the brain and spinal cord?

    <p>Meninges</p> Signup and view all the answers

    What does the sympathetic division of the autonomic nervous system stimulate during times of stress?

    <p>Heart rate</p> Signup and view all the answers

    Where do the axons of efferent sympathetic nerves synapse with cells?

    <p>Near the spinal cord</p> Signup and view all the answers

    What is regulated by the autonomic nervous system?

    <p>Digestion and blood pressure</p> Signup and view all the answers

    What is characteristic of parasympathetic postganglionic neurons?

    <p>Are quite short and release acetylcholine</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Browser