Pharmacology: Sulphonylureas and DPP4 Inhibitors
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Questions and Answers

What is the maximum daily dose of Gliclazide?

  • 320mg (correct)
  • 240mg
  • 160mg
  • 400mg
  • What is the rare adverse effect of GLP1 analogues?

  • Hypoglycaemia
  • Gastrointestinal upset
  • Weight loss
  • Pancreatitis (correct)
  • Which DPP4 Inhibitor is best suited for patients with poor renal function?

  • Sitagliptin
  • Alogliptin
  • Linagliptin (correct)
  • Saxagliptin
  • What is the mechanism of action of Pioglitazone?

    <p>Activates DNA to induce transcription of genes involved in lipid and carbohydrate metabolism</p> Signup and view all the answers

    What is the rare but serious adverse effect of DPP4 Inhibitors?

    <p>Pancreatitis</p> Signup and view all the answers

    What is the precaution for Pioglitazone in patients with heart failure?

    <p>Monitor for signs of heart failure and discontinue if deterioration occurs</p> Signup and view all the answers

    What is the recommendation for patients at high risk of type 2 diabetes?

    <p>Offer metformin to support lifestyle change</p> Signup and view all the answers

    What is the initial dose of Liraglutide?

    <p>0.6mg s/c OD for at least one week</p> Signup and view all the answers

    What is the caution/contraindication common to both Sulphonylureas and DPP4 Inhibitors?

    <p>Pancreatitis</p> Signup and view all the answers

    What is the goal of the prevention of T2DM strategy?

    <p>To reduce the incidence of type 2 diabetes</p> Signup and view all the answers

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