Pharmacology: Sulphonylureas and DPP4 Inhibitors
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Questions and Answers

What is the maximum daily dose of Gliclazide?

  • 320mg (correct)
  • 240mg
  • 160mg
  • 400mg

What is the rare adverse effect of GLP1 analogues?

  • Hypoglycaemia
  • Gastrointestinal upset
  • Weight loss
  • Pancreatitis (correct)

Which DPP4 Inhibitor is best suited for patients with poor renal function?

  • Sitagliptin
  • Alogliptin
  • Linagliptin (correct)
  • Saxagliptin

What is the mechanism of action of Pioglitazone?

<p>Activates DNA to induce transcription of genes involved in lipid and carbohydrate metabolism (A)</p> Signup and view all the answers

What is the rare but serious adverse effect of DPP4 Inhibitors?

<p>Pancreatitis (A)</p> Signup and view all the answers

What is the precaution for Pioglitazone in patients with heart failure?

<p>Monitor for signs of heart failure and discontinue if deterioration occurs (B)</p> Signup and view all the answers

What is the recommendation for patients at high risk of type 2 diabetes?

<p>Offer metformin to support lifestyle change (B)</p> Signup and view all the answers

What is the initial dose of Liraglutide?

<p>0.6mg s/c OD for at least one week (A)</p> Signup and view all the answers

What is the caution/contraindication common to both Sulphonylureas and DPP4 Inhibitors?

<p>Pancreatitis (C)</p> Signup and view all the answers

What is the goal of the prevention of T2DM strategy?

<p>To reduce the incidence of type 2 diabetes (D)</p> Signup and view all the answers

Flashcards

Max daily dose of Gliclazide

320mg

Rare GLP1 analogue side effect

Pancreatitis

DPP4 best for kidney issues

Linagliptin

Pioglitazone's mechanism

Activates genes for lipid/carb metabolism

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Rare DPP4 inhibitor side effect

Pancreatitis

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Pioglitazone heart failure precaution

Monitor & stop if worsening

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High T2DM risk recommendation

Metformin with lifestyle changes

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Starting dose of Liraglutide

0.6mg s/c daily for a week

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Sulfonylureas/DPP4 Inhibitors caution

Pancreatitis risk

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T2DM prevention goal

Reduce incidence

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