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Pharmacology: Sulphonylureas and DPP4 Inhibitors

10 Questions

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Pharmacology: Sulphonylureas and DPP4 Inhibitors

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Questions and Answers

What is the maximum daily dose of Gliclazide?

320mg (correct)

240mg

160mg

400mg

What is the rare adverse effect of GLP1 analogues?

Hypoglycaemia

Gastrointestinal upset

Weight loss

Pancreatitis (correct)

Which DPP4 Inhibitor is best suited for patients with poor renal function?

Sitagliptin

Alogliptin

Linagliptin (correct)

Saxagliptin

What is the mechanism of action of Pioglitazone?

Activates DNA to induce transcription of genes involved in lipid and carbohydrate metabolism Signup and view all the answers

What is the rare but serious adverse effect of DPP4 Inhibitors?

Pancreatitis Signup and view all the answers

What is the precaution for Pioglitazone in patients with heart failure?

Monitor for signs of heart failure and discontinue if deterioration occurs Signup and view all the answers

What is the recommendation for patients at high risk of type 2 diabetes?

Offer metformin to support lifestyle change Signup and view all the answers

What is the initial dose of Liraglutide?

0.6mg s/c OD for at least one week Signup and view all the answers

What is the caution/contraindication common to both Sulphonylureas and DPP4 Inhibitors?

Pancreatitis Signup and view all the answers

What is the goal of the prevention of T2DM strategy?

To reduce the incidence of type 2 diabetes Signup and view all the answers