Pharmacology: Sulphonylureas and DPP4 Inhibitors

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10 Questions

What is the maximum daily dose of Gliclazide?

320mg

What is the rare adverse effect of GLP1 analogues?

Pancreatitis

Which DPP4 Inhibitor is best suited for patients with poor renal function?

Linagliptin

What is the mechanism of action of Pioglitazone?

Activates DNA to induce transcription of genes involved in lipid and carbohydrate metabolism

What is the rare but serious adverse effect of DPP4 Inhibitors?

Pancreatitis

What is the precaution for Pioglitazone in patients with heart failure?

Monitor for signs of heart failure and discontinue if deterioration occurs

What is the recommendation for patients at high risk of type 2 diabetes?

Offer metformin to support lifestyle change

What is the initial dose of Liraglutide?

0.6mg s/c OD for at least one week

What is the caution/contraindication common to both Sulphonylureas and DPP4 Inhibitors?

Pancreatitis

What is the goal of the prevention of T2DM strategy?

To reduce the incidence of type 2 diabetes

Test your knowledge of sulphonylureas, such as gliclazide, and DPP4 inhibitors, including their dosages, adverse effects, and precautions. Learn about the importance of taking sulphonylureas with food and managing risks in certain patient populations.

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