Pharmacology Quiz: Rifampin Antimicrobial Properties

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What is the half-life of the drug discussed?

6 hours (correct)

Less than 6 hours

12 hours

More than 12 hours

Why must patients be warned when taking Rifampin?

It may interact with other medications

It will impart an orange-red color to body fluids (correct)

It may cause severe side effects

It can cause allergic reactions

What is the main reason Rifampin and Isoniazid are always used in combination?

To increase their efficacy

To reduce the cost of treatment

To reduce side effects

To prevent resistance to one drug (correct)

What is the typical use of Capreomycin and Viomycin?

When resistance is developed to 1st and 2nd line drugs Signup and view all the answers

Where is the drug present in effective concentrations?

Throughout the total body water, including many organs and body fluids, including CSF Signup and view all the answers

What is the effect of Rifampin on serum transaminase in certain populations?

It causes a minor elevation in serum transaminase Signup and view all the answers

What is the primary antibacterial action of Streptomycin?

Preventing the synthesis of cross-linking peptide in the formation of cell wall Signup and view all the answers

What is the mechanism of action of Rifamycins in regards to bacterial DNA-dependent RNA synthesis?

Inhibiting DDRP by binding to the [3-subunit Signup and view all the answers

What is associated with mutations in the rpoB gene?

Resistance to Rifamycins Signup and view all the answers

What is the characteristic of Rifampin pharmacokinetics?

Rapidly eliminated in the bile and reabsorbed through enterohepatic circulation Signup and view all the answers

What is the effect of aminosalicylic acid on Rifampin elimination?

Delays Rifampin elimination Signup and view all the answers

What is the mechanism of action of Streptomycin on alanine?

It acts as a suicide substrate for alanine racemase Signup and view all the answers

What is the primary mechanism of action of para-aminosalicylic acid (PAS)?

Being active only against growing tubercular bacilli Signup and view all the answers

What is the main route of excretion for isoniazid (INH)?

Urine Signup and view all the answers

What is the primary concern for adverse effects of isoniazid (INH)?

Hepatotoxicity Signup and view all the answers

What is the main metabolite of isoniazid (INH)?

Acetylisoniazid Signup and view all the answers

What is the half-life of para-aminosalicylic acid (PAS)?

2 hours Signup and view all the answers

Why is the combination of INH and PAS effective against tuberculosis?

PAS increases the level of free INH Signup and view all the answers