Pharmacology Quiz: Rifampin Antimicrobial Properties
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Questions and Answers

What is the half-life of the drug discussed?

  • 6 hours (correct)
  • Less than 6 hours
  • 12 hours
  • More than 12 hours

    • Why must patients be warned when taking Rifampin?

  • It may interact with other medications
  • It will impart an orange-red color to body fluids (correct)
  • It may cause severe side effects
  • It can cause allergic reactions

    • What is the main reason Rifampin and Isoniazid are always used in combination?

  • To increase their efficacy
  • To reduce the cost of treatment
  • To reduce side effects
  • To prevent resistance to one drug (correct)

    • What is the typical use of Capreomycin and Viomycin?

    <p>When resistance is developed to 1st and 2nd line drugs</p> Signup and view all the answers

    Where is the drug present in effective concentrations?

    <p>Throughout the total body water, including many organs and body fluids, including CSF</p> Signup and view all the answers

    What is the effect of Rifampin on serum transaminase in certain populations?

    <p>It causes a minor elevation in serum transaminase</p> Signup and view all the answers

    What is the primary antibacterial action of Streptomycin?

    <p>Preventing the synthesis of cross-linking peptide in the formation of cell wall</p> Signup and view all the answers

    What is the mechanism of action of Rifamycins in regards to bacterial DNA-dependent RNA synthesis?

    <p>Inhibiting DDRP by binding to the [3-subunit</p> Signup and view all the answers

    What is associated with mutations in the rpoB gene?

    <p>Resistance to Rifamycins</p> Signup and view all the answers

    What is the characteristic of Rifampin pharmacokinetics?

    <p>Rapidly eliminated in the bile and reabsorbed through enterohepatic circulation</p> Signup and view all the answers

    What is the effect of aminosalicylic acid on Rifampin elimination?

    <p>Delays Rifampin elimination</p> Signup and view all the answers

    What is the mechanism of action of Streptomycin on alanine?

    <p>It acts as a suicide substrate for alanine racemase</p> Signup and view all the answers

    What is the primary mechanism of action of para-aminosalicylic acid (PAS)?

    <p>Being active only against growing tubercular bacilli</p> Signup and view all the answers

    What is the main route of excretion for isoniazid (INH)?

    <p>Urine</p> Signup and view all the answers

    What is the primary concern for adverse effects of isoniazid (INH)?

    <p>Hepatotoxicity</p> Signup and view all the answers

    What is the main metabolite of isoniazid (INH)?

    <p>Acetylisoniazid</p> Signup and view all the answers

    What is the half-life of para-aminosalicylic acid (PAS)?

    <p>2 hours</p> Signup and view all the answers

    Why is the combination of INH and PAS effective against tuberculosis?

    <p>PAS increases the level of free INH</p> Signup and view all the answers

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