Pharmacology Quiz on Drugs and Mechanisms
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Questions and Answers

Which of the following drugs is NOT a first-line anti-tubercular drug?

  • Isoniazide
  • Kanamycin (correct)
  • Ethambutol
  • Rifampicin
  • Which drug specifically targets mycolic acid synthesis?

  • Rifampicin
  • Ethambutol
  • Isoniazide
  • Pyrazinamide (correct)
  • Which of the following drugs targets DNA-dependent RNA polymerase?

  • Ethambutol
  • Rifampicin (correct)
  • Pyrazinamide
  • Isoniazide
  • Which of the following antibiotics is NOT typically used to treat tuberculosis?

    <p>Azithromycin (A)</p> Signup and view all the answers

    Which category of anti-tubercular drugs is typically associated with lower efficacy and higher toxicity?

    <p>Second-line drugs (A)</p> Signup and view all the answers

    Which route of administration is used to treat a deep fungal infection?

    <p>Intravenous (D)</p> Signup and view all the answers

    Which of the following is a 2nd generation fluoroquinolone?

    <p>Ciprofloxacin (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Amphotericin B?

    <p>Effective against Meningitis (C)</p> Signup and view all the answers

    What is the primary mechanism of action of fluoroquinolones?

    <p>Inhibition of DNA synthesis (B)</p> Signup and view all the answers

    What is the mechanism of action of Griseofulvin?

    <p>Binding to ergosterol (C)</p> Signup and view all the answers

    What is the main reason for the contraindication of fluoroquinolones in young patients?

    <p>Possible interference with cartilage development (B)</p> Signup and view all the answers

    What is a potential consequence of cell membrane disruption by antifungal drugs?

    <p>Cell leakage (C)</p> Signup and view all the answers

    Which of the following is a characteristic of fluoroquinolones as compared to non-fluorinated quinolones?

    <p>Increased resistance to bacterial enzymatic degradation (C)</p> Signup and view all the answers

    Which of the following antifungal drugs is known to have poor oral absorption?

    <p>MIA (C)</p> Signup and view all the answers

    Which of the following is NOT a contraindication for fluoroquinolone use?

    <p>Kidney disease (A)</p> Signup and view all the answers

    Flashcards

    Fluoroquinolones

    A class of antibiotics that contain a fluorine atom and act on DNA synthesis.

    Classification of Fluoroquinolones

    Divided into various generations based on chemical structure and effectiveness like non-fluorinated, 2nd gen, and 3rd gen.

    11th gen - Non Fluorinated

    Includes drugs like Nalidixic acid, primarily for treating urinary tract infections (UTIs).

    Mechanism of Action (M/A)

    Fluoroquinolones work by inhibiting DNA synthesis, affecting replication and unwinding.

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    Contraindications of Fluoroquinolones

    Not suitable for young (affects cartilage) and pregnant individuals due to potential risks.

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    First line anti-tubercular drugs

    Initial treatment for tuberculosis with high efficacy and low toxicity.

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    Isoniazide

    A first-line anti-tubercular drug effective against Mycobacteria.

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    Rifampicin

    First-line drug that inhibits DNA-dependent RNA polymerase in Mycobacteria.

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    Second line anti-tubercular drugs

    Used in special cases with low efficacy and high toxicity.

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    Ciprofloxacin

    A newer anti-tubercular drug used for treating resistant strains.

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    Amphotericin B

    An antifungal drug that targets ergosterol in fungal cell membranes.

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    Griseofulvin

    An antifungal that also targets ergosterol, typically used for superficial infections.

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    Ergosterol

    A key component in fungal cell membranes targeted by antifungal drugs.

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    Dosage of Amphotericin B

    Dose range is 0.1-1 mg/kg for effective treatment, though nephrotoxicity is a risk.

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    Route of administration

    Amphotericin B can be administered topically, orally, or IV to target different types of infections.

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