Pharmacology Quiz on Drugs and Mechanisms

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Questions and Answers

Which of the following drugs is NOT a first-line anti-tubercular drug?

  • Isoniazide
  • Kanamycin (correct)
  • Ethambutol
  • Rifampicin

Which drug specifically targets mycolic acid synthesis?

  • Rifampicin
  • Ethambutol
  • Isoniazide
  • Pyrazinamide (correct)

Which of the following drugs targets DNA-dependent RNA polymerase?

  • Ethambutol
  • Rifampicin (correct)
  • Pyrazinamide
  • Isoniazide

Which of the following antibiotics is NOT typically used to treat tuberculosis?

<p>Azithromycin (A)</p> Signup and view all the answers

Which category of anti-tubercular drugs is typically associated with lower efficacy and higher toxicity?

<p>Second-line drugs (A)</p> Signup and view all the answers

Which route of administration is used to treat a deep fungal infection?

<p>Intravenous (D)</p> Signup and view all the answers

Which of the following is a 2nd generation fluoroquinolone?

<p>Ciprofloxacin (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of Amphotericin B?

<p>Effective against Meningitis (C)</p> Signup and view all the answers

What is the primary mechanism of action of fluoroquinolones?

<p>Inhibition of DNA synthesis (B)</p> Signup and view all the answers

What is the mechanism of action of Griseofulvin?

<p>Binding to ergosterol (C)</p> Signup and view all the answers

What is the main reason for the contraindication of fluoroquinolones in young patients?

<p>Possible interference with cartilage development (B)</p> Signup and view all the answers

What is a potential consequence of cell membrane disruption by antifungal drugs?

<p>Cell leakage (C)</p> Signup and view all the answers

Which of the following is a characteristic of fluoroquinolones as compared to non-fluorinated quinolones?

<p>Increased resistance to bacterial enzymatic degradation (C)</p> Signup and view all the answers

Which of the following antifungal drugs is known to have poor oral absorption?

<p>MIA (C)</p> Signup and view all the answers

Which of the following is NOT a contraindication for fluoroquinolone use?

<p>Kidney disease (A)</p> Signup and view all the answers

Flashcards

Fluoroquinolones

A class of antibiotics that contain a fluorine atom and act on DNA synthesis.

Classification of Fluoroquinolones

Divided into various generations based on chemical structure and effectiveness like non-fluorinated, 2nd gen, and 3rd gen.

11th gen - Non Fluorinated

Includes drugs like Nalidixic acid, primarily for treating urinary tract infections (UTIs).

Mechanism of Action (M/A)

Fluoroquinolones work by inhibiting DNA synthesis, affecting replication and unwinding.

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Contraindications of Fluoroquinolones

Not suitable for young (affects cartilage) and pregnant individuals due to potential risks.

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First line anti-tubercular drugs

Initial treatment for tuberculosis with high efficacy and low toxicity.

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Isoniazide

A first-line anti-tubercular drug effective against Mycobacteria.

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Rifampicin

First-line drug that inhibits DNA-dependent RNA polymerase in Mycobacteria.

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Second line anti-tubercular drugs

Used in special cases with low efficacy and high toxicity.

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Ciprofloxacin

A newer anti-tubercular drug used for treating resistant strains.

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Amphotericin B

An antifungal drug that targets ergosterol in fungal cell membranes.

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Griseofulvin

An antifungal that also targets ergosterol, typically used for superficial infections.

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Ergosterol

A key component in fungal cell membranes targeted by antifungal drugs.

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Dosage of Amphotericin B

Dose range is 0.1-1 mg/kg for effective treatment, though nephrotoxicity is a risk.

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Route of administration

Amphotericin B can be administered topically, orally, or IV to target different types of infections.

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