Pharmacology of Antitubercular Drugs
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Questions and Answers

A patient diagnosed with tuberculosis is prescribed isoniazid (INH). The nurse recognizes that pyridoxine (vitamin B6) is often co-prescribed with INH to prevent which side effect?

  • Hepatitis
  • Skin rash
  • Optic neuritis
  • Peripheral neuropathy (correct)
  • The nurse is educating a patient on rifampin therapy for tuberculosis. Which statement indicates the patient needs further teaching?

  • I need to take this medication exactly as prescribed to prevent resistance.
  • I should report any unusual symptoms to my healthcare provider.
  • I should expect red-orange discoloration of my urine and tears.
  • I can wear my contact lenses as usual while taking this medication. (correct)
  • A patient on ethambutol therapy reports difficulty distinguishing between red and green colors. What is the nurse's best action?

  • Reassure the patient that this is a normal side effect.
  • Advise the patient to increase dietary intake of vitamin B6.
  • Instruct the patient to stop the medication immediately.
  • Notify the healthcare provider for further evaluation. (correct)
  • A nurse is administering pyrazinamide to a patient with active tuberculosis. The nurse monitors for which primary adverse effect?

    <p>Hepatotoxicity</p> Signup and view all the answers

    A patient is prescribed Rifater (a combination of rifampin, isoniazid, and pyrazinamide) for tuberculosis. What is the purpose of using a combination therapy?

    <p>To prevent the development of drug resistance</p> Signup and view all the answers

    A patient receiving isoniazid (INH) reports tingling and numbness in their hands and feet. What is the nurse's priority intervention?

    <p>Administer pyridoxine (vitamin B6) as prescribed.</p> Signup and view all the answers

    The nurse is teaching a patient about the adverse effects of ethambutol. Which statement by the patient demonstrates correct understanding?

    <p>I should report any changes in my vision to my healthcare provider.</p> Signup and view all the answers

    A patient taking rifampin for tuberculosis asks why the medication must be taken as part of a combination regimen. What is the nurse's best response?

    <p>Combination therapy helps prevent the development of drug resistance.</p> Signup and view all the answers

    During a follow-up visit, a patient on pyrazinamide therapy reports nausea and mild upper abdominal pain. What is the nurse's priority action?

    <p>Assess liver function tests.</p> Signup and view all the answers

    A patient with tuberculosis asks why they must undergo visual acuity and color perception tests while taking ethambutol. What is the nurse's best response?

    <p>Ethambutol can affect your optic nerve and cause vision problems.</p> Signup and view all the answers

    A nurse is caring for a patient receiving Rifater. Which combination of medications does Rifater include?

    <p>Rifampin, pyrazinamide, isoniazid</p> Signup and view all the answers

    A patient is started on tuberculosis therapy with multiple medications. The nurse emphasizes the importance of adherence to therapy. What is the primary reason for this instruction?

    <p>To avoid the development of multidrug-resistant tuberculosis</p> Signup and view all the answers

    Study Notes

    Question 1

    • Pyridoxine (vitamin B6) is often co-prescribed with isoniazid (INH) to prevent peripheral neuropathy.
    • Hepatitis, optic neuritis, and skin rashes are not prevented by vitamin B6.

    Question 2

    • Rifampin therapy for tuberculosis can cause red-orange discoloration of urine and tears.
    • Patients should not use contact lenses while taking rifampin.
    • Patients should take the medication exactly as prescribed, to prevent resistance.
    • Patients should report any unusual symptoms to their healthcare provider.

    Question 3

    • Patients on ethambutol therapy may experience difficulty distinguishing between red and green colors.
    • Notify the healthcare provider for further evaluation.
    • Ethambutol can cause optic neuritis, which may present as difficulty distinguishing colors or decreased visual acuity.

    Question 4

    • Hepatotoxicity is a primary adverse effect of pyrazinamide, which is monitored by liver function tests.
    • Red-orange discoloration of body fluids is an adverse effect of rifampin.
    • Peripheral neuropathy is an adverse effect of isoniazid.
    • Optic neuritis is an adverse effect of ethambutol.

    Question 5

    • Rifater (combination therapy) is used to prevent drug resistance in tuberculosis.
    • Combination therapies for tuberculosis can minimize therapy duration, improve patient compliance, and reduce side effects.

    Question 6

    • Tingling and numbness in hands and feet are symptoms of peripheral neuropathy.
    • Administer pyridoxine (vitamin B6) as prescribed.

    Question 7

    • Patients should report any changes in vision to their healthcare provider when taking ethambutol.
    • Ethambutol can cause optic neuritis.
    • Red-orange discoloration is a side effect of rifampin.
    • Tingling is a possible side effect of isoniazid.

    Question 8

    • Combination therapy helps prevent the development of drug resistance in tuberculosis.
    • Rifampin can be effective on its own, but resistance develops quickly when not used with other drugs.

    Question 9

    • Assess liver function tests as a priority if a patient taking pyrazinamide reports nausea or mild upper abdominal pain.
    • Monitoring liver function tests identifies potential liver damage (hepatotoxicity).

    Question 10

    • Conduct visual acuity and color perception tests before and during treatment to detect potential problems.
    • Ethambutol can cause optic neuritis, which may result in vision changes, including decreased acuity and color blindness.

    Question 11

    • Rifater contains rifampin, pyrazinamide, and isoniazid.

    Question 12

    • Adherence is important to avoid the development of multidrug-resistant tuberculosis.
    • Multiple medications are used to ensure more effective treatment.

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    Description

    This quiz covers important information regarding the pharmacological properties and side effects of antitubercular medications such as isoniazid, rifampin, ethambutol, and pyrazinamide. It emphasizes critical monitoring and patient education to mitigate risks associated with these drugs. Test your knowledge on these vital aspects of tuberculosis therapy.

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