Pharmacology Problems: Calculating Drug Dosage and Euthanasia
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Questions and Answers

In which type of experiment are isolated organs or tissues used?

  • Ex vivo
  • In vitro (correct)
  • In situ
  • In vivo

What is an advantage of working in vitro?

  • Easy to adjust experimental factors
  • Avoid interference by hormones and neurotransmitters (correct)
  • Larger doses of the drug are required
  • Biotransformation, distribution, and elimination are accounted for

What is a crucial factor to consider when working in vitro?

  • Type of animal used
  • Color of the equipment
  • pH of the solution (correct)
  • Brand of the experimental instruments

How should rabbits be handled during experimentation?

<p>With minimal pressure or excitement (A)</p> Signup and view all the answers

What is the route of administration for a drug in frogs?

<p>Subcutaneous (SC) (A)</p> Signup and view all the answers

What is the formula to calculate the drug volume to be administered?

<p>Weight x Suggested drug dose / Drug concentration (C)</p> Signup and view all the answers

What is the concentration of the drug required in this case?

<p>2% (2g / 100ml) (B)</p> Signup and view all the answers

What is the purpose of euthanizing animals at the end of a study?

<p>For the purpose of sample collection or postmortem examination (B)</p> Signup and view all the answers

What is the recommended method of euthanasia for rodents?

<p>Carbon dioxide (CO2) or Sodium Pentobarbital (C)</p> Signup and view all the answers

What is the site of blood collection for mice?

<p>Cardiac, orbital sinus, tail vein, facial vein (C)</p> Signup and view all the answers

What is the minimum dose of Sodium Pentobarbital required for euthanasia in rodents?

<p>100 mg/kg IV, IP (D)</p> Signup and view all the answers

Why is anesthesia required for blood collection in animals?

<p>To reduce the animal's stress and pain (A)</p> Signup and view all the answers

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