Podcast
Questions and Answers
What is the process by which a drug moves from its administration site into the bloodstream?
What is the process by which a drug moves from its administration site into the bloodstream?
Which route of administration has 100% bioavailability?
Which route of administration has 100% bioavailability?
What occurs when a drug is metabolized in the gut wall and liver before reaching the systemic circulation?
What occurs when a drug is metabolized in the gut wall and liver before reaching the systemic circulation?
What is the circulation of substances from the liver to the bile, followed by entry into the small intestine, and absorption by the enterocyte and transport back to the liver?
What is the circulation of substances from the liver to the bile, followed by entry into the small intestine, and absorption by the enterocyte and transport back to the liver?
Signup and view all the answers
What is the dispersal of drugs from the systemic circulation to other tissues and the site of action?
What is the dispersal of drugs from the systemic circulation to other tissues and the site of action?
Signup and view all the answers
What is the fraction of the drug that reaches the blood circulation following administration by any route?
What is the fraction of the drug that reaches the blood circulation following administration by any route?
Signup and view all the answers
What is the definition of pharmacology?
What is the definition of pharmacology?
Signup and view all the answers
What is the primary route of drug administration that involves the digestive tract?
What is the primary route of drug administration that involves the digestive tract?
Signup and view all the answers
What is the process by which a drug is broken down?
What is the process by which a drug is broken down?
Signup and view all the answers
Which type of drugs primarily binds to albumin?
Which type of drugs primarily binds to albumin?
Signup and view all the answers
What is the definition of pharmacokinetics?
What is the definition of pharmacokinetics?
Signup and view all the answers
What is the primary function of the Blood Brain Barrier?
What is the primary function of the Blood Brain Barrier?
Signup and view all the answers
What is the structure of the intestinal epithelium composed of?
What is the structure of the intestinal epithelium composed of?
Signup and view all the answers
What is the primary factor that determines the ability of a drug to cross the Blood Brain Barrier?
What is the primary factor that determines the ability of a drug to cross the Blood Brain Barrier?
Signup and view all the answers
What is the advantage of the enteral route of drug administration?
What is the advantage of the enteral route of drug administration?
Signup and view all the answers
What is the only form of the drug available for action, metabolism, and excretion?
What is the only form of the drug available for action, metabolism, and excretion?
Signup and view all the answers
What is the effect of protein binding on the duration of action of a drug?
What is the effect of protein binding on the duration of action of a drug?
Signup and view all the answers
Which type of drugs can cross the placental barrier?
Which type of drugs can cross the placental barrier?
Signup and view all the answers
Study Notes
Drug Absorption and Bioavailability
- Absorption describes the process by which a drug moves from its administration site into the bloodstream.
- Intravenous (IV) administration provides 100% bioavailability, allowing complete drug absorption directly into circulation.
- First-pass metabolism occurs when a drug is metabolized in the gut wall and liver before reaching systemic circulation, reducing its effectiveness.
- Bioavailability refers to the fraction of the drug that reaches the bloodstream after administration by any route.
Drug Distribution and Movement
- Distribution entails the dispersal of drugs from systemic circulation to various tissues and their sites of action.
- The enterohepatic circulation involves substances moving from the liver to bile, into the small intestine, where they are absorbed by enterocytes and returned to the liver.
Pharmacological Concepts
- Pharmacology is defined as the study of drugs, their effects, and their mechanisms of action.
- Pharmacokinetics focuses on how drugs are absorbed, distributed, metabolized, and excreted in the body.
Administration Routes and Drug Properties
- The primary route of drug administration involving the digestive tract is the enteral route.
- Drugs primarily binding to albumin are typically those that are highly protein-bound, affecting their bioavailability and duration.
- Protein binding prolongs the duration of a drug's action by limiting its availability for metabolism and elimination.
Barriers and Drug Characteristics
- The Blood-Brain Barrier (BBB) protects the central nervous system by restricting the passage of certain substances, ensuring only selective compounds enter.
- The ability of a drug to cross the BBB is largely determined by its lipid solubility, size, and ability to interact with transporter proteins.
Drug Forms and Effects
- The only drug form available for action, metabolism, and excretion is the unbound (free) drug.
- Lipid-soluble drugs are more likely to cross the placental barrier, influencing the safety and effects on fetal development.
Structural Considerations
- The intestinal epithelium is composed of a single layer of cells, forming a barrier for drug absorption and interaction.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Test your understanding of pharmacology principles, including drug administration, absorption, distribution, metabolism, and excretion. This quiz covers the basics of pharmacology, ideal for students of pharmacy and medicine.
