Pharmacology: Parasympathetic Agonists
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Questions and Answers

Which of the following is NOT a response to stimulation of M1 cholinergic receptors?

  • Increased secretions from salivary glands
  • Increased heart rate (correct)
  • Relaxation of smooth muscle
  • Decreased heart rate

What is the primary mechanism by which Ach causes vasodilation?

  • Release of NO from endothelial cells (correct)
  • Inhibition of sympathetic nervous system activity
  • Direct relaxation of vascular smooth muscle
  • Stimulation of muscarinic receptors in vascular smooth muscle

Which of the following is an example of an indirectly acting cholinomimetic?

  • Physostigmine (correct)
  • Bethanechol
  • Pilocarpine
  • Carbachol

What is the primary fate of orally administered Ach?

<p>Rapid destruction by cholinesterases (A)</p> Signup and view all the answers

Which of the following is a CNS effect of Ach?

<p>Neurotransmission and cognitive function (B)</p> Signup and view all the answers

What is the classification of Neostigmine?

<p>Indirectly acting cholinomimetic (D)</p> Signup and view all the answers

What is the primary effect of atropine on the heart rate in healthy young individuals?

<p>Initially bradycardia followed by tachycardia (A)</p> Signup and view all the answers

What is the primary mechanism of atropine's antispasmodic action on the GIT?

<p>Decrease in tone and motility (B)</p> Signup and view all the answers

What is the effect of large doses of atropine on the CNS?

<p>Restlessness and hallucination followed by depression and medullary paralysis (B)</p> Signup and view all the answers

What is the primary mechanism of atropine's action on the autonomic nervous system?

<p>Inhibition of the parasympathetic nervous system (B)</p> Signup and view all the answers

What is the primary route of excretion of atropine?

<p>Renal excretion (A)</p> Signup and view all the answers

What is the primary effect of therapeutic doses of atropine on the medulla?

<p>Stimulation and increased respiration (C)</p> Signup and view all the answers

What is the effect of muscarinic actions on the urinary tract?

<p>Increase motility and tone, and relax the sphincters (D)</p> Signup and view all the answers

Which of the following is a nicotinic action of choline esters?

<p>Muscle twitches (B)</p> Signup and view all the answers

What is the effect of muscarinic actions on the eye?

<p>Miosis, increase lacrimation, and decrease IOP (A)</p> Signup and view all the answers

Which of the following is a peripheral effect of choline esters?

<p>Increase in gastrointestinal motility (B)</p> Signup and view all the answers

What is the primary autonomic nervous system effect of choline esters?

<p>Stimulation of the parasympathetic nervous system (C)</p> Signup and view all the answers

What is the therapeutic use of pilocarpine?

<p>Treatment of glaucoma (A)</p> Signup and view all the answers

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