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Pharmacology: Parasympathetic Agonists

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Questions and Answers

Which of the following is NOT a response to stimulation of M1 cholinergic receptors?

Increased secretions from salivary glands

Increased heart rate (correct)

Relaxation of smooth muscle

Decreased heart rate

What is the primary mechanism by which Ach causes vasodilation?

Release of NO from endothelial cells (correct)

Inhibition of sympathetic nervous system activity

Direct relaxation of vascular smooth muscle

Stimulation of muscarinic receptors in vascular smooth muscle

Which of the following is an example of an indirectly acting cholinomimetic?

Physostigmine (correct)

Bethanechol

Pilocarpine

Carbachol

What is the primary fate of orally administered Ach?

Rapid destruction by cholinesterases Signup and view all the answers

Which of the following is a CNS effect of Ach?

Neurotransmission and cognitive function Signup and view all the answers

What is the classification of Neostigmine?

Indirectly acting cholinomimetic Signup and view all the answers

What is the primary effect of atropine on the heart rate in healthy young individuals?

Initially bradycardia followed by tachycardia Signup and view all the answers

What is the primary mechanism of atropine's antispasmodic action on the GIT?

Decrease in tone and motility Signup and view all the answers

What is the effect of large doses of atropine on the CNS?

Restlessness and hallucination followed by depression and medullary paralysis Signup and view all the answers

What is the primary mechanism of atropine's action on the autonomic nervous system?

Inhibition of the parasympathetic nervous system Signup and view all the answers

What is the primary route of excretion of atropine?

Renal excretion Signup and view all the answers

What is the primary effect of therapeutic doses of atropine on the medulla?

Stimulation and increased respiration Signup and view all the answers

What is the effect of muscarinic actions on the urinary tract?

Increase motility and tone, and relax the sphincters Signup and view all the answers

Which of the following is a nicotinic action of choline esters?

Muscle twitches Signup and view all the answers

What is the effect of muscarinic actions on the eye?

Miosis, increase lacrimation, and decrease IOP Signup and view all the answers

Which of the following is a peripheral effect of choline esters?

Increase in gastrointestinal motility Signup and view all the answers

What is the primary autonomic nervous system effect of choline esters?

Stimulation of the parasympathetic nervous system Signup and view all the answers

What is the therapeutic use of pilocarpine?

Treatment of glaucoma Signup and view all the answers