Pharmacology Ondansetron Flashcards

Questions and Answers

What is the therapeutic class of Ondansetron?

Antihistamines

Antiemetics (correct)

Antidepressants

Analgesics

What is the pharmacologic class of Ondansetron?

Calcium channel blockers

5-HT3 antagonists (correct)

Serotonin reuptake inhibitors

Beta-blockers

What is the expected pharmacologic action of Ondansetron?

Blocks the effects of serotonin at 5-HT3 receptor sites located in vagal nerve terminals and the chemoreceptor trigger zone in CNS.

What is the therapeutic use of Ondansetron?

Decreased incidence and severity of nausea and vomiting following chemotherapy or surgery. Signup and view all the answers

What are some side/adverse effects of Ondansetron?

Headache, dizziness, drowsiness, fatigue, Torsades de Pointes, constipation, diarrhea. Signup and view all the answers

What is the correct medication administration route for Ondansetron?

PO for orally disintegrating tablets and IV undiluted. Signup and view all the answers

What are the contraindications/precautions of Ondansetron?

Hypersensitivity, use in patients with phenylketonurias, concurrent use with apomorphine, hepatic impairment, and abdominal surgery. Signup and view all the answers

What are some nursing interventions for Ondansetron?

Assess patient for nausea and vomiting, monitor ECG in patients with hypokalemia, hypomagnesemia, and heart failure. Signup and view all the answers

What are some interactions of Ondansetron?

Apomorphine, carbamazepine, phenytoin, and rifampin. Signup and view all the answers

How can the effectiveness of Ondansetron be evaluated?

Prevention of nausea and vomiting with emetogenic cancer chemotherapy, radiation therapy, and postoperative nausea and vomiting. Signup and view all the answers

What client education should be provided regarding Ondansetron?

Instruct to take as directed and notify HCP immediately if symptoms of irregular heartbeat or involuntary movement occur. Signup and view all the answers

Study Notes

Ondansetron Overview

Therapeutic class: antiemetics, used to prevent nausea and vomiting.
Pharmacologic class: 5-HT3 antagonists, targeting serotonin receptors.

Pharmacologic Action

Blocks serotonin effects at 5-HT3 receptor sites in vagal nerve terminals and the CNS chemoreceptor trigger zone.

Therapeutic Uses

Reduces incidence and severity of nausea and vomiting post-chemotherapy and surgery.

Side/Adverse Effects

Common: headache, dizziness, drowsiness, fatigue.
Serious: TORSADE DE POINTES, constipation, diarrhea.

Medication Administration

Oral administration: Use orally disintegrating tablets without removing from foil; place directly on the tongue to dissolve.
IV administration: Administer undiluted.

Contraindications/Precautions

Not for use in patients with hypersensitivity or phenylketonuria (due to aspartame).
Avoid concurrent use with apomorphine.
Caution in patients with hepatic impairment or undergoing abdominal surgery.

Nursing Interventions

Assess for signs of nausea and vomiting.
Monitor ECG in patients with electrolyte imbalances or heart failure.

Drug Interactions

Caution when used with apomorphine, carbamazepine, phenytoin, and rifampin.

Evaluation of Effectiveness

Effective in preventing nausea/vomiting from emetogenic cancer chemotherapy, radiation therapy, and postoperative scenarios.

Client Education

Advise strict adherence to dosing instructions.
Instruct to report any irregular heartbeat or involuntary movements of eyes, face, or limbs immediately.

Description

Test your knowledge on Ondansetron with these flashcards. Explore its therapeutic and pharmacologic classes, expected actions, and therapeutic uses. Perfect for students and professionals looking to enhance their understanding of this important antiemetic drug.