Questions and Answers
What is the generic name for Zofran?
What class of medication does ondansetron belong to?
Gastrointestinal agent; antiemetic; 5-HT3 antagonist
Ondansetron is classified as a pregnancy category D medication.
False
What forms of ondansetron are available?
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What is a contraindication for ondansetron?
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Caution should be exercised when using ondansetron in pregnancy and lactation.
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The standard dosage for nausea and vomiting in adults is ___ mg taken orally 30 minutes before chemotherapy.
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Which of the following is NOT listed as an adverse effect of ondansetron?
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What should be monitored as a nursing implication when administering ondansetron?
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Patients should be aware that headache requiring an analgesic for relief is a common adverse effect of ___.
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Study Notes
Ondansetron Overview
- Generic Name: Ondansetron hydrochloride
- Brand Names: Zofran, Zofran ODT
Classifications
- Type: Gastrointestinal agent, antiemetic
- Mechanism: 5-HT3 receptor antagonist
Pregnancy and Availability
- Pregnancy Category: B, indicating no evidence of risk in humans
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Dosage Forms:
- Tablets: 4 mg, 8 mg, 24 mg
- Orally disintegrating tablets: 4 mg, 8 mg
- Oral solution: 4 mg/5 mL
- Injection: 2 mg/mL, 32 mg/5 mL
Contraindications and Cautious Use
- Contraindications: Hypersensitivity to ondansetron
- Cautious Use: Should be used carefully during pregnancy and while lactating
Dosage Information
-
Nausea and Vomiting:
- Adults: Oral 8 mg, taken 30 min before chemotherapy, followed by additional doses every 8 hours
- IV dosing for ages 6 months to 18 years: 0.15 mg/kg or 32 mg infused over 15 minutes, repeated after 4 and 8 hours
- Highly Emetogenic Chemotherapy (Adults): Single oral dose of 24 mg, 30 min before chemotherapy
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Postoperative Nausea and Vomiting (Adults):
- Oral dose of 8-16 mg 1 hour preoperatively or IM 4 mg prior to anesthesia induction
- IV 4 mg, repeat every 8 hours as needed
- Hyperemesis Gravidarum (Adults): Oral/IV 4-8 mg, 2-3 times daily
- Hepatic Impairment: Maximum of 8 mg daily for severely impaired liver function
Adverse Effects
- CNS: Dizziness, light-headedness, headache, sedation
- Gastrointestinal: Diarrhea, constipation, dry mouth; may cause transient increases in liver enzymes and bilirubin
- Allergic Reactions: Potential hypersensitivity reactions
Nursing Implications
- Monitoring: Observe fluid and electrolyte balance due to risk of diarrhea
- Cardiovascular Monitoring: Required for patients with coronary artery disease; tachycardia and angina reported in rare cases
Patient Education
- Adverse Effects Awareness: Inform patients that headache commonly requires analgesics for relief
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Description
This quiz provides an overview of Ondansetron, including its classifications, dosage information, and safety during pregnancy. Test your knowledge on how this gastrointestinal agent works and its applications in treating nausea and vomiting.
