Ondansetron Flashcards

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Questions and Answers

What is another name for ondansetron?

  • Advil
  • Tylenol
  • Zofran ODT (correct)
  • Zofran (correct)

What is the official or generic name of the drug?

ondansetron

The classification of ondansetron falls under ________ and five HT3 antagonists.

Therapeutic class antiemetics

What is the primary action of ondansetron?

<p>Blocks the effects of serotonin at 5HT3 receptor sites</p> Signup and view all the answers

What are the uses of ondansetron? (Select all that apply)

<p>Prevention of nausea and vomiting associated with chemotherapy (A), Prevention of postoperative nausea and vomiting (D)</p> Signup and view all the answers

Which are the usual methods of administration for ondansetron?

<p>IV (B), PO (C), IM (D)</p> Signup and view all the answers

Which are common toxic manifestations of ondansetron?

<p>Constipation (A), Diarrhea (C), Headache (D)</p> Signup and view all the answers

What is the pregnancy category for ondansetron?

<p>Category B</p> Signup and view all the answers

What should patients be advised regarding ondansetron?

<p>Notify health care professional immediately if symptoms of irregular heartbeat occur.</p> Signup and view all the answers

Nursing assessments for ondansetron include assessing the patient for ________ and bowel sounds.

<p>nausea, vomiting, abdominal distention</p> Signup and view all the answers

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Study Notes

Ondansetron Overview

  • Commonly known as Zofran or Zofran ODT.
  • Generic name is ondansetron.

Classifications

  • Therapeutic Classification: Antiemetics.
  • Pharmacological Classification: 5-HT3 antagonists.

Chief Actions

  • Mechanism: Blocks serotonin effects at 5-HT3 receptor sites.
  • Primary Locations: Found in the vagal nerve terminals and chemoreceptor trigger zone in the Central Nervous System (CNS).
  • Therapeutic Effect: Reduces incidence and severity of nausea and vomiting after chemotherapy or surgery.

Uses

  • Prevents nausea and vomiting from highly or moderately emetogenic chemotherapy.
  • Oral dosage form used for radiation therapy-related nausea and vomiting.
  • Effective in preventing and treating postoperative nausea and vomiting.

Administration Methods

  • Available routes: Oral (PO), Intravenous (IV), Intramuscular (IM).

Toxic Manifestations

  • Common adverse effects: Headache, constipation, diarrhea.
  • Serious risk: Torsades de pointes, a potentially life-threatening arrhythmia.

Pregnancy Category

  • Classified as Category B, indicating no proven risk in humans.

Patient Education

  • Patients should take ondansetron as directed.
  • Advise immediate reporting of symptoms like irregular heartbeat or involuntary movements.

Nursing Assessments

  • Evaluate for nausea, vomiting, abdominal distention, and bowel sounds before and after administration.
  • Monitor for extrapyramidal symptoms, including involuntary movements and facial grimacing during therapy.
  • Regular ECG monitoring for patients at risk (hypokalemia, hypomagnesemia, heart failure, bradyarrhythmias, or those on QT-prolonging medications).
  • Laboratory considerations include potential transient increases in serum bilirubin, AST, and ALT levels.

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