Pharmacology of Physostigmine and Neostigmine

<p>Management of myasthenia gravis (A)</p> Signup and view all the answers

<p>Tertiary amine (D)</p> Signup and view all the answers

<p>Regenerates cholinesterase (C)</p> Signup and view all the answers

<p>To prevent enzyme aging (A)</p> Signup and view all the answers

<p>Increased intraocular pressure (B)</p> Signup and view all the answers

<p>Inhibition of cholinesterase, causing acetylcholine accumulation (D)</p> Signup and view all the answers

<p>Management of myasthenia gravis (B)</p> Signup and view all the answers

<p>Physostigmine penetrates lipid barriers while Neostigmine does not (C)</p> Signup and view all the answers

<p>Natural plant alkaloid (D)</p> Signup and view all the answers

<p>Increased motility (A)</p> Signup and view all the answers

<p>12 hours (B)</p> Signup and view all the answers

<p>Miosis (D)</p> Signup and view all the answers

<p>By stimulating bladder contraction (D)</p> Signup and view all the answers

A natural plant alkaloid that inhibits acetylcholinesterase (AChE), leading to increased acetylcholine levels at various sites, causing muscarinic, nicotinic, and central nervous system (CNS) effects. It can cross the blood-brain barrier.

A synthetic drug that inhibits acetylcholinesterase (AChE) and is used to increase acetylcholine levels. Unlike physostigmine, it does not readily cross the blood-brain barrier.

A drug that specifically reactivates cholinesterase enzymes that have been inhibited by organophosphate poisons, like those found in pesticides. It works by breaking the bond between the organophosphate and the enzyme.

The ability of a drug to cross the blood-brain barrier, which separates the bloodstream from the central nervous system. Drugs that can cross this barrier can affect the brain.

The actions of a drug that are related to the release or stimulation of acetylcholine, leading to changes in muscle activity, heart rate, and other bodily functions.

A specific type of cholinergic action that affects muscle movement. This action can be either direct (stimulating muscle directly) or indirect (acting on acetylcholine receptors in the muscle).

A specific type of cholinergic action that affects skeletal muscle, primarily by acting on receptors at the neuromuscular junction, leading to muscle contraction.

Drugs that relieve or prevent convulsions, often used to treat epilepsy and other seizure disorders.

A chemical compound that blocks the enzyme acetylcholinesterase (AChE), leading to an accumulation of acetylcholine at various sites in the body.

The ability of a substance to cross the blood-brain barrier, a protective membrane that separates the bloodstream from the central nervous system.