Pharmacology of Neurotransmitters: GABA and NMDA Receptors
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Questions and Answers

What is the effect of benzodiazepines and barbiturates on the receptor?

  • They bind directly to the active site
  • They augment channel opening (correct)
  • They have no effect on channel opening
  • They block channel opening
  • What is the result of glycine binding to glutamate receptors?

  • It binds directly to the active site
  • It reduces the effects of NMDA
  • It enhances the effects of NMDA (correct)
  • It has no effect on NMDA
  • Which type of receptors are linked to inhibition of cAMP, pre- and post-synaptic inhibition?

  • GABA
  • Type B
  • GPCR (correct)
  • NMDA
  • What is the effect of increasing K+ conductance on neuronal excitability?

    <p>It decreases neuronal excitability</p> Signup and view all the answers

    What is the result of inhibiting Ca2+ opening?

    <p>It decreases neuronal excitability</p> Signup and view all the answers

    What is necessary for a drug to have an effect on a target in the brain?

    <p>It must be able to enter the brain and remain there for a sufficient period</p> Signup and view all the answers

    What is the primary effect of acetylcholine on skeletal muscle?

    <p>Excitatory</p> Signup and view all the answers

    Which type of receptor is involved in the sympathetic actions of noradrenaline?

    <p>Nicotinic receptors</p> Signup and view all the answers

    What is the effect of dopamine on movement?

    <p>Excitation</p> Signup and view all the answers

    What is the result of the degeneration of dopaminergic neurones of the nigrostriatal tract?

    <p>Parkinsonism</p> Signup and view all the answers

    Which type of receptor is linked to adenylyl cyclase and phospholipids?

    <p>D2 receptors</p> Signup and view all the answers

    What is the effect of acetylcholine on cardiac muscle?

    <p>Inhibitory</p> Signup and view all the answers

    What is the primary function of NMDA receptors in terms of ion channel control?

    <p>They allow the entry of sodium and Ca2+ ions and exit of potassium ions</p> Signup and view all the answers

    What is the role of glycine in NMDA receptor function?

    <p>It acts as a co-agonist to facilitate the action of NMDA</p> Signup and view all the answers

    What is the effect of GABA binding to its receptors on Cl- channels?

    <p>It opens the Cl- channel, leading to an inhibitory influence</p> Signup and view all the answers

    What is the primary function of 5-HT2 receptors in terms of neuronal activity?

    <p>They produce inhibitory post-synaptic potentials</p> Signup and view all the answers

    Which type of GABA receptor is similar in structure to nicotinic receptors?

    <p>Type A</p> Signup and view all the answers

    What is the effect of NMDA receptor activation on the resting state of the neuron?

    <p>It decreases the concentration of Mg2+ ions</p> Signup and view all the answers

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