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Pharmacology of Neurotransmitters: GABA and NMDA Receptors

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Questions and Answers

What is the effect of benzodiazepines and barbiturates on the receptor?

They bind directly to the active site
They augment channel opening (correct)
They have no effect on channel opening
They block channel opening

What is the result of glycine binding to glutamate receptors?

It binds directly to the active site
It reduces the effects of NMDA
It enhances the effects of NMDA (correct)
It has no effect on NMDA

Which type of receptors are linked to inhibition of cAMP, pre- and post-synaptic inhibition?

GABA
Type B
GPCR (correct)
NMDA

What is the effect of increasing K+ conductance on neuronal excitability?

It decreases neuronal excitability (A) Signup and view all the answers

What is the result of inhibiting Ca2+ opening?

It decreases neuronal excitability (B) Signup and view all the answers

What is necessary for a drug to have an effect on a target in the brain?

It must be able to enter the brain and remain there for a sufficient period (B) Signup and view all the answers

What is the primary effect of acetylcholine on skeletal muscle?

Excitatory (B) Signup and view all the answers

Which type of receptor is involved in the sympathetic actions of noradrenaline?

Nicotinic receptors (A) Signup and view all the answers

What is the effect of dopamine on movement?

Excitation (A) Signup and view all the answers

What is the result of the degeneration of dopaminergic neurones of the nigrostriatal tract?

Parkinsonism (B) Signup and view all the answers

Which type of receptor is linked to adenylyl cyclase and phospholipids?

D2 receptors (C) Signup and view all the answers

What is the effect of acetylcholine on cardiac muscle?

Inhibitory (A) Signup and view all the answers

What is the primary function of NMDA receptors in terms of ion channel control?

They allow the entry of sodium and Ca2+ ions and exit of potassium ions (C) Signup and view all the answers

What is the role of glycine in NMDA receptor function?

It acts as a co-agonist to facilitate the action of NMDA (A) Signup and view all the answers

What is the effect of GABA binding to its receptors on Cl- channels?

It opens the Cl- channel, leading to an inhibitory influence (C) Signup and view all the answers

What is the primary function of 5-HT2 receptors in terms of neuronal activity?

They produce inhibitory post-synaptic potentials (C) Signup and view all the answers

Which type of GABA receptor is similar in structure to nicotinic receptors?

Type A (C) Signup and view all the answers

What is the effect of NMDA receptor activation on the resting state of the neuron?

It decreases the concentration of Mg2+ ions (A) Signup and view all the answers

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