18 Questions
What is the effect of benzodiazepines and barbiturates on the receptor?
They augment channel opening
What is the result of glycine binding to glutamate receptors?
It enhances the effects of NMDA
Which type of receptors are linked to inhibition of cAMP, pre- and post-synaptic inhibition?
GPCR
What is the effect of increasing K+ conductance on neuronal excitability?
It decreases neuronal excitability
What is the result of inhibiting Ca2+ opening?
It decreases neuronal excitability
What is necessary for a drug to have an effect on a target in the brain?
It must be able to enter the brain and remain there for a sufficient period
What is the primary effect of acetylcholine on skeletal muscle?
Excitatory
Which type of receptor is involved in the sympathetic actions of noradrenaline?
Nicotinic receptors
What is the effect of dopamine on movement?
Excitation
What is the result of the degeneration of dopaminergic neurones of the nigrostriatal tract?
Parkinsonism
Which type of receptor is linked to adenylyl cyclase and phospholipids?
D2 receptors
What is the effect of acetylcholine on cardiac muscle?
Inhibitory
What is the primary function of NMDA receptors in terms of ion channel control?
They allow the entry of sodium and Ca2+ ions and exit of potassium ions
What is the role of glycine in NMDA receptor function?
It acts as a co-agonist to facilitate the action of NMDA
What is the effect of GABA binding to its receptors on Cl- channels?
It opens the Cl- channel, leading to an inhibitory influence
What is the primary function of 5-HT2 receptors in terms of neuronal activity?
They produce inhibitory post-synaptic potentials
Which type of GABA receptor is similar in structure to nicotinic receptors?
Type A
What is the effect of NMDA receptor activation on the resting state of the neuron?
It decreases the concentration of Mg2+ ions
Test your knowledge of benzodiazepines, barbiturates, and their effects on GABA and NMDA receptors. Learn about the key components of these receptors and their ligand binding sites, including the role of glycine as an inhibitory transmitter.
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