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Questions and Answers
What is the common property of injectable local anesthetic agents?
Which of the following is a characteristic of an ideal local anesthetic?
How do local anesthetics affect nerve conduction?
What do local anesthetics form when injected into the body?
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What is the primary mode of action of local anesthetics according to the most favored theory?
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Which type of local anesthetics are commonly used esters, including tetracaine, procaine, and cocaine?
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Which theory of action of local anesthesia suggests that the local anesthetic dissolves in the lipid contents of nerve tissues, leading to temporary coagulation and prevention of nerve impulses conduction?
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Which theory of action of local anesthesia suggests interference with acetylcholine at synaptic function to prevent nerve conduction?
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What form are local anesthetics dispensed for injection, making them soluble in water & comparatively stable?
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What is responsible for binding to the protein receptor site in sodium channel for nerve conduction blockage?
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Study Notes
Properties of Local Anesthetic Agents
- Injectable local anesthetic agents have a common property of being amphipathic, meaning they have both hydrophobic and hydrophilic parts.
Ideal Local Anesthetic Characteristics
- An ideal local anesthetic should have a rapid onset, long duration, and low toxicity.
Mechanism of Action
- Local anesthetics affect nerve conduction by blocking the generation and conduction of nerve impulses.
- When injected into the body, local anesthetics form a complex with the sodium channel receptor site.
Types of Local Anesthetics
- Esters, including tetracaine, procaine, and cocaine, are commonly used local anesthetics.
Theories of Action
- The lipid dissolution theory suggests that local anesthetics dissolve in the lipid contents of nerve tissues, leading to temporary coagulation and prevention of nerve impulses conduction.
- The acetylcholine theory suggests that local anesthetics interfere with acetylcholine at synaptic function to prevent nerve conduction.
Dispensing of Local Anesthetics
- Local anesthetics are dispensed for injection in a hydrochloride salt form, making them soluble in water and comparatively stable.
Nerve Conduction Blockage
- The binding of local anesthetics to the protein receptor site in the sodium channel is responsible for nerve conduction blockage.
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Description
Test your knowledge of local anesthetics and their characteristics with this quiz. Topics include local anesthetic agents, ideal characteristics, and more.
