Pharmacology of Blood Lipids

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Which enzyme is responsible for the rate limiting step of hepatic cholesterol synthesis?

HMG-CoA reductase

Which lipoprotein is mainly composed of cholesterol?

LDL

Which lipoprotein is responsible for transporting cholesterol from tissue cells back to the liver?

HDL

Which lipoprotein is the main carrier of cholesterol?

<p>LDL</p> Signup and view all the answers

Which lipoprotein is synthesized in the liver and participates in the reverse transport of cholesterol to the liver?

<p>HDL</p> Signup and view all the answers

Which lipoprotein is responsible for transporting larger amounts of triglycerides compared to cholesterol?

<p>VLDL</p> Signup and view all the answers

What is the most frequent cause of hyperlipidemia?

<p>Dietary excess</p> Signup and view all the answers

Which drugs inhibit the Niemann-Pick C1-Like1 (NPC1L1) cholesterol transporter?

<p>Ezetimibe</p> Signup and view all the answers

Which drug is used as an adjunct to diet to reduce triglyceride levels in adults with severe hypertriglyceridemia?

<p>Icosapent Ethyl</p> Signup and view all the answers

Which class of drugs has the greatest LDL-C reduction of any hypolipidemic drugs?

<p>HMG-CoA Reductase Inhibitors</p> Signup and view all the answers

Which adverse effect is associated with cholestyramine use?

<p>Bloating</p> Signup and view all the answers

Which enzyme is responsible for the rate limiting step of hepatic cholesterol synthesis?

<p>HMG-CoA reductase</p> Signup and view all the answers

Which lipoprotein is responsible for transporting larger amounts of triglycerides compared to cholesterol?

<p>Chylomicron</p> Signup and view all the answers

Which lipoprotein carries the apolipoprotein B-100 and is bound to receptors of target organs for cholesterol uptake?

<p>LDL</p> Signup and view all the answers

Which lipoprotein is responsible for transporting triglycerides to the adipose tissue, heart, and skeletal muscle?

<p>Chylomicrons</p> Signup and view all the answers

Which lipoprotein is synthesized in the liver and releases triglycerides to the adipose tissue, heart, and skeletal muscle?

<p>VLDL</p> Signup and view all the answers

Which lipoprotein is the source of LDL?

<p>IDL</p> Signup and view all the answers

Which lipoprotein is responsible for the reverse transport of cholesterol to the liver?

<p>HDL</p> Signup and view all the answers

Which drug class has the highest LDL-C reduction among hypolipidemic drugs?

<p>HMG-CoA Reductase Inhibitors</p> Signup and view all the answers

What is the main effect of ezetimibe?

<p>Reduces intestinal cholesterol absorption</p> Signup and view all the answers

What is the mechanism of action of icosapent ethyl?

<p>Reduces hepatic production of triglyceride-rich VLDL</p> Signup and view all the answers

Which adverse effect is associated with HMG-CoA Reductase Inhibitors?

<p>Rhabdomyolysis</p> Signup and view all the answers

Which enzyme is responsible for the rate limiting step of hepatic cholesterol synthesis?

<p>HMG-CoA reductase</p> Signup and view all the answers

Which lipoprotein is responsible for transporting cholesterol from tissue cells back to the liver?

<p>HDL</p> Signup and view all the answers

Which class of drugs has the greatest LDL-C reduction of any hypolipidemic drugs?

<p>HMG-CoA Reductase Inhibitors</p> Signup and view all the answers

Which lipoprotein is responsible for transporting cholesterol from tissue cells back to the liver?

<p>HDL</p> Signup and view all the answers

Which lipoprotein carries the apolipoprotein B-100 and is bound to receptors of target organs for cholesterol uptake?

<p>LDL</p> Signup and view all the answers

Which lipoprotein is responsible for transporting larger amounts of triglycerides compared to cholesterol?

<p>VLDL</p> Signup and view all the answers

Which lipoprotein is mainly composed of cholesterol?

<p>Chylomicrons</p> Signup and view all the answers

Which drug class is known for its ability to bind lipid soluble molecules and inhibit their absorption, including fat-soluble vitamins and lipophilic drugs?

<p>Bile Acid Sequestering Resins</p> Signup and view all the answers

Which drug inhibits the Niemann-Pick C1-Like1 (NPC1L1) cholesterol transporter, leading to increased enteral cholesterol excretion and reduced intestinal cholesterol absorption?

<p>Ezetimibe</p> Signup and view all the answers

Which drug class is the most important therapeutics for lowering LDL cholesterol?

<p>HMG-CoA Reductase Inhibitors</p> Signup and view all the answers

Which drug is used as an adjunct to diet to reduce triglyceride levels in adults with severe hypertriglyceridemia, and as an adjunct to maximally tolerated statin therapy in adult patients with high triglyceride levels and cardiovascular risk factors?

<p>Icosapent Ethyl</p> Signup and view all the answers

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