Adrenergic Receptors and Agonists
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Questions and Answers

What is the primary transmitter at postganglionic sympathetic sites?

  • Dopamine
  • Serotonin
  • Adrenaline
  • Noradrenaline (correct)
  • Which endogenous catecholamine is secreted by the adrenal medulla?

  • Serotonin
  • Adrenaline (correct)
  • Acetylcholine
  • Dopamine
  • Which enzyme inhibition can result in the depletion of catecholamines?

  • DOPA decarboxylase inhibition
  • Acetylcholinesterase inhibition
  • Tyrosine hydroxylase inhibition (correct)
  • Monoamine oxidase inhibition
  • What is the rate-limiting enzyme in catecholamine biosynthesis?

    <p>Tyrosine hydroxylase</p> Signup and view all the answers

    Which enzyme can form serotonin from 5-hydroxytryptophan?

    <p>DOPA decarboxylase</p> Signup and view all the answers

    In which areas of the brain does dopamine act as a major transmitter?

    <p>Basal ganglia</p> Signup and view all the answers

    According to Ahlquist's classification, how many types of adrenergic receptors were identified based on potency rank order?

    <p>Two: alpha and beta receptors</p> Signup and view all the answers

    What is the main difference between the synthesis of NA and Adrenaline?

    <p>NA synthesis occurs in all adrenergic neurones, while Adrenaline synthesis occurs only in adrenal medullary cells.</p> Signup and view all the answers

    Which subtype of adrenergic receptors mediates lipolysis and induces thermogenesis located on adipocytes?

    <p>Beta3 receptors</p> Signup and view all the answers

    What led to the subdivision of beta receptors into beta1 and beta2 subtypes?

    <p>Selective agonists and antagonists</p> Signup and view all the answers

    How many subtypes of alpha1 receptors have been identified through molecular cloning?

    <p>Three: alpha1A, alpha1B, and alpha1D</p> Signup and view all the answers

    What characterizes the present classification of prejunctional alpha receptors into alpha1 and alpha2?

    <p>Pharmacological criteria (selectivity of agonists and antagonists)</p> Signup and view all the answers

    What is the effect of Phenylephrine on the release of insulin?

    <p>Inhibits the release of insulin</p> Signup and view all the answers

    What is the pharmacological effect of adrenaline on conducting tissue?

    <p>Increases heart rate</p> Signup and view all the answers

    Which area experiences decongestion of mucosa/submucosa due to adrenergic action?

    <p>Gastrointestinal tract</p> Signup and view all the answers

    What is the primary effect of β1 adrenergic receptors on the heart?

    <p>Increased cardiac activity</p> Signup and view all the answers

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