16 Questions
What is the primary transmitter at postganglionic sympathetic sites?
Noradrenaline
Which endogenous catecholamine is secreted by the adrenal medulla?
Adrenaline
Which enzyme inhibition can result in the depletion of catecholamines?
Tyrosine hydroxylase inhibition
What is the rate-limiting enzyme in catecholamine biosynthesis?
Tyrosine hydroxylase
Which enzyme can form serotonin from 5-hydroxytryptophan?
DOPA decarboxylase
In which areas of the brain does dopamine act as a major transmitter?
Basal ganglia
According to Ahlquist's classification, how many types of adrenergic receptors were identified based on potency rank order?
Two: alpha and beta receptors
What is the main difference between the synthesis of NA and Adrenaline?
NA synthesis occurs in all adrenergic neurones, while Adrenaline synthesis occurs only in adrenal medullary cells.
Which subtype of adrenergic receptors mediates lipolysis and induces thermogenesis located on adipocytes?
Beta3 receptors
What led to the subdivision of beta receptors into beta1 and beta2 subtypes?
Selective agonists and antagonists
How many subtypes of alpha1 receptors have been identified through molecular cloning?
Three: alpha1A, alpha1B, and alpha1D
What characterizes the present classification of prejunctional alpha receptors into alpha1 and alpha2?
Pharmacological criteria (selectivity of agonists and antagonists)
What is the effect of Phenylephrine on the release of insulin?
Inhibits the release of insulin
What is the pharmacological effect of adrenaline on conducting tissue?
Increases heart rate
Which area experiences decongestion of mucosa/submucosa due to adrenergic action?
Gastrointestinal tract
What is the primary effect of β1 adrenergic receptors on the heart?
Increased cardiac activity
Explore the topic of adrenergic receptors and agonists in pharmacology with this quiz by Adejuwon Adeneye. Learn about the role of noradrenaline in postganglionic sympathetic sites and the three closely related endogenous catecholamines.
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