Adrenergic Receptors and Agonists
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Questions and Answers

What is the primary transmitter at postganglionic sympathetic sites?

  • Dopamine
  • Serotonin
  • Adrenaline
  • Noradrenaline (correct)

Which endogenous catecholamine is secreted by the adrenal medulla?

  • Serotonin
  • Adrenaline (correct)
  • Acetylcholine
  • Dopamine

Which enzyme inhibition can result in the depletion of catecholamines?

  • DOPA decarboxylase inhibition
  • Acetylcholinesterase inhibition
  • Tyrosine hydroxylase inhibition (correct)
  • Monoamine oxidase inhibition

What is the rate-limiting enzyme in catecholamine biosynthesis?

<p>Tyrosine hydroxylase (A)</p> Signup and view all the answers

Which enzyme can form serotonin from 5-hydroxytryptophan?

<p>DOPA decarboxylase (C)</p> Signup and view all the answers

In which areas of the brain does dopamine act as a major transmitter?

<p>Basal ganglia (D)</p> Signup and view all the answers

According to Ahlquist's classification, how many types of adrenergic receptors were identified based on potency rank order?

<p>Two: alpha and beta receptors (D)</p> Signup and view all the answers

What is the main difference between the synthesis of NA and Adrenaline?

<p>NA synthesis occurs in all adrenergic neurones, while Adrenaline synthesis occurs only in adrenal medullary cells. (D)</p> Signup and view all the answers

Which subtype of adrenergic receptors mediates lipolysis and induces thermogenesis located on adipocytes?

<p>Beta3 receptors (A)</p> Signup and view all the answers

What led to the subdivision of beta receptors into beta1 and beta2 subtypes?

<p>Selective agonists and antagonists (C)</p> Signup and view all the answers

How many subtypes of alpha1 receptors have been identified through molecular cloning?

<p>Three: alpha1A, alpha1B, and alpha1D (D)</p> Signup and view all the answers

What characterizes the present classification of prejunctional alpha receptors into alpha1 and alpha2?

<p>Pharmacological criteria (selectivity of agonists and antagonists) (A)</p> Signup and view all the answers

What is the effect of Phenylephrine on the release of insulin?

<p>Inhibits the release of insulin (D)</p> Signup and view all the answers

What is the pharmacological effect of adrenaline on conducting tissue?

<p>Increases heart rate (A)</p> Signup and view all the answers

Which area experiences decongestion of mucosa/submucosa due to adrenergic action?

<p>Gastrointestinal tract (D)</p> Signup and view all the answers

What is the primary effect of β1 adrenergic receptors on the heart?

<p>Increased cardiac activity (A)</p> Signup and view all the answers

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