Pharmacology: Mode of Action of Antibiotics
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Questions and Answers

What is the primary target of fluoroquinolones in Gram (-) bacteria?

  • Cytoplasmic membrane
  • Topoisomerase IV
  • RNA polymerase
  • DNA gyrase (topoisomerase II) (correct)

    • Rifamycins selectively bind to which subunit of bacterial RNA polymerase?

  • α subunit
  • ß subunit (correct)
  • γ subunit
  • δ subunit

    • What is the primary mode of action of rifamycins?

  • Inhibition of protein synthesis
  • Inhibition of DNA synthesis
  • Inhibition of RNA transcription (correct)
  • Disruption of cytoplasmic membrane

    • Which antibiotic is specifically used to treat infections caused by Mycobacterium tuberculosis?

    <p>Rifampin</p> Signup and view all the answers

    What is the primary target of fluoroquinolones in Gram (+) bacteria?

    <p>Topoisomerase IV</p> Signup and view all the answers

    Polymyxin acts by disrupting which structure in bacterial cells?

    <p>Cytoplasmic membrane</p> Signup and view all the answers

    What is the primary mode of action of polymyxins?

    <p>Disruption of cytoplasmic membrane</p> Signup and view all the answers

    Which of the following antibiotics inhibits DNA synthesis?

    <p>Fluoroquinolones</p> Signup and view all the answers

    What is the primary mode of action of fluoroquinolones?

    <p>Inhibition of DNA synthesis</p> Signup and view all the answers

    Daptomycin acts by which mode of action?

    <p>Selective disruption of cytoplasmic membrane</p> Signup and view all the answers

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