Pharmacology: Lipid Nature of Drugs and Skin Permeation
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Questions and Answers

What is the main reason why drug transport through skin is possible?

  • The watery nature of the stratum corneum
  • The hairy nature of the skin
  • Lipoid nature of the intercellular medium (correct)
  • The presence of sebaceous glands
  • Which transport route involves the movement of drugs between corneocytes?

  • Trans-appendageal route
  • Intracellular route
  • Intercellular route (correct)
  • Transcellular route
  • What is the primary lipid component of the intercellular medium?

  • Phospholipids (correct)
  • Cholesterol
  • Fatty acids
  • Ceramide
  • Which route of transport is suitable for small molecules only?

    <p>Intercellular route</p> Signup and view all the answers

    What is the primary function of sebaceous glands in skin transport?

    <p>To provide a shunt route for drugs</p> Signup and view all the answers

    What is the term for transport through hair follicles and sebaceous glands?

    <p>Trans-appendageal transport</p> Signup and view all the answers

    Which route of transport involves the movement of drugs through corneocytes?

    <p>Transcellular route</p> Signup and view all the answers

    What is the most abundant route of drug transport through the skin?

    <p>Stratum corneum permeation</p> Signup and view all the answers

    What is the primary obstacle in drug permeation through the skin?

    <p>Passing through the stratum corneum</p> Signup and view all the answers

    What is transappendageal transport?

    <p>Drug transport through the skin appendages</p> Signup and view all the answers

    Which type of transport is also known as shunt route transport?

    <p>Transappendageal transport</p> Signup and view all the answers

    What are the skin appendages responsible for transappendageal transport?

    <p>Sweat glands, hair follicles, and sebaceous glands</p> Signup and view all the answers

    What is the term for the movement of a drug within a membrane composed of more than one layer?

    <p>Penetration</p> Signup and view all the answers

    What is the advantage of transappendageal transport?

    <p>It is a fast pathway with no barrier effect of stratum corneum</p> Signup and view all the answers

    What is the unit of drug permeation through a membrane?

    <p>cm/min</p> Signup and view all the answers

    Which of the following is an example of transcellular transport?

    <p>Intracellular and intercellular transport</p> Signup and view all the answers

    Why is the sweet gland route not influential to drug transport?

    <p>It is a rare route</p> Signup and view all the answers

    What is the disadvantage of transappendageal transport?

    <p>It is a rare route</p> Signup and view all the answers

    What is the term for the routes of drug permeation through the skin?

    <p>Skin permeation pathways</p> Signup and view all the answers

    What happens to the drug molecules after they enter the sweat glands?

    <p>They are transported through the sweat ducts</p> Signup and view all the answers

    Which type of transport is considered EASY and FAST but LESS COMMON?

    <p>Transappendageal transport</p> Signup and view all the answers

    What is the role of the blood capillaries surrounding the sweat glands and sebaceous glands?

    <p>They absorb the drug molecules</p> Signup and view all the answers

    What is the name of the outermost layer of the skin that is a significant barrier to drug permeation?

    <p>Stratum corneum</p> Signup and view all the answers

    What happens to the drug molecules after they enter the hair follicles and sebaceous glands?

    <p>They are transported through the sebaceous sacs</p> Signup and view all the answers

    Study Notes

    Skin Permeation Pathways

    • Lipoid nature of drugs allows them to pass easily through sweet glands, hair follicles, and sebaceous glands
    • Targeted effect is needed for shunt transport through hair follicle and sebaceous glands routes
    • Skin permeation pathways refer to the routes of drug permeation through the skin

    Transport Through Stratum Corneum

    • Most abundant route of drug transport through the skin
    • Two main routes:
      • Intercellular route: drug moves between corneocytes till it reaches viable epidermis
      • Transcellular route: drug moves through corneocytes till it reaches viable epidermis

    Intercellular Route

    • Intercellular medium is lipid in nature, composed of phospholipids, ceramide, and cholesterol
    • Suitable for small molecules with a molecular weight of less than 400 dalton
    • Permeation coefficient (P) expresses the rate of drug permeation through the membrane

    Transappendageal Transport (Shunt Route)

    • Drug transport through skin appendages (sweet glands, hair follicles, and sebaceous glands)
    • Easy and fast pathway, but less common
    • Advantage: no barrier effect of stratum corneum, but disadvantage: rare route with insignificant contribution to drug transport

    Transport Through Sweet Glands and Hair Follicles

    • Transport through sweet glands:
      • Drug molecules enter sweet openings
      • Travel through sweet ducts
      • Reach sweet glands
      • Absorbed by blood capillaries surrounding sweet glands
    • Transport through hair follicles and sebaceous glands:
      • Drug molecules enter hair openings
      • Travel through sebaceous sacs
      • Reach sebaceous glands
      • Absorbed by blood capillaries surrounding sebaceous glands

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    Description

    This quiz covers the lipoid nature of certain drugs, how they pass through the skin, and the routes of skin permeation, including sweet glands and hair follicles. It's essential for understanding targeted drug effects.

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