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Questions and Answers
What is a primary function of interferons?
What is a primary function of interferons?
- Increase blood pressure
- Bind to receptors to inhibit cell growth (correct)
- Enhance the activity of platelets
- Stimulate the growth of cancer cells
Which of the following is a potential side effect to monitor for when administering interleukins?
Which of the following is a potential side effect to monitor for when administering interleukins?
- Neuropsychiatric disorders
- Immediate hypertension
- Severe gastrointestinal bleeding
- Capillary leak syndrome (correct)
What should patients receiving interferons be instructed to report immediately?
What should patients receiving interferons be instructed to report immediately?
- Symptoms of infection (correct)
- Fatigue during exercise
- Increased appetite
- Mild headaches
Which laboratory values should be monitored during treatment with interleukins?
Which laboratory values should be monitored during treatment with interleukins?
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What symptom might indicate pancreatitis in a patient receiving interferons?
What symptom might indicate pancreatitis in a patient receiving interferons?
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Study Notes
Interferons
- Interferon alfa-2b (Intron A) and peginterferon alfa-2b (PegIntron, Sylatron) are examples of interferons.
- Interferons bind to receptors to inhibit cell growth.
- Monitor patients for cardiovascular status, pancreatitis, neuropsychiatric disorders, and colitis.
- Instruct patients to notify their healthcare provider immediately if they experience signs of infection, lower back or side pain, painful or difficult urination, bleeding, suicidal thoughts or attempts, new or worsening anxiety, depression, agitation, or aggressive or violent behavior.
Interleukins
- Aldesleukin (Proleukin) is an example of an interleukin.
- Interleukins stimulate T cells, B cells, and NK cells to attack cancer cells.
- Monitor patients for complete blood count with differential, platelet count, electrolytes, kidney, liver, and thyroid function.
- Monitor cardiovascular status continuously during transfusion.
- Monitor for capillary leak syndrome (hypotension, hypovolemia, edema, ascites, pleural effusion).
- Monitor respiratory status, weight daily, and skin for the development of rash or blisters.
- Monitor for signs of infection.
- Instruct patients to notify their healthcare provider if they develop symptoms of infection, liver dysfunction, unusual bleeding or bruising, or increased fatigue.
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