Pharmacology for Nursing Care: Antimicrobials
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Questions and Answers

What is a notable advantage of combining bacteriostatic drugs?

  • They only target gram-positive bacteria.
  • They have no side effects.
  • They produce a bactericidal action. (correct)
  • They significantly increase the MIC of each component.
  • Which of the following is NOT a toxicity related to sulfonamides?

  • Renal damage due to crystal deposition
  • Kernicterus in neonates
  • Megaloblastic anemia (correct)
  • Photosensitivity
  • What is a reason for the continued use of sulfonamides even after many years?

  • They have a wide antibacterial spectrum.
  • They are cheap and easy to administer orally. (correct)
  • They can be used as single agents for all infections.
  • They are expensive and complex to administer.
  • What is a possible outcome of combining trimethoprim and sulfonamides?

    <p>Delayed development of bacterial resistance.</p> Signup and view all the answers

    In which population is kernicterus most likely to occur due to sulfonamide treatment?

    <p>Premature infants</p> Signup and view all the answers

    What is Imipenem commonly used with to increase its effectiveness?

    <p>Cilastatin</p> Signup and view all the answers

    Which side effect is more likely with Imipenem compared to Meropenem?

    <p>Increased bleeding tendency</p> Signup and view all the answers

    What is a unique characteristic of Aztreonam?

    <p>Relatively resistant to beta-lactamase</p> Signup and view all the answers

    What is the primary use of Vancomycin?

    <p>Bactericidal agent for MRSA and MRSE</p> Signup and view all the answers

    What form of Vancomycin is used to treat C.difficile colitis?

    <p>PO form</p> Signup and view all the answers

    What is the primary mechanism by which sulfanilamide exerts its effects?

    <p>Competitive inhibition of dihydropteroate synthase</p> Signup and view all the answers

    Which statement correctly describes the selectivity between microbes and humans regarding precursor synthesis?

    <p>Microbes can synthesize precursors to dihydrofolic acid, while humans cannot</p> Signup and view all the answers

    What is a shared characteristic between the dihydrofolate reductase in humans and microbes?

    <p>Both can reduce dihydrofolic acid</p> Signup and view all the answers

    What is the role of trimethoprim in the combination therapy with sulfamethoxazole?

    <p>It specifically inhibits the microbial dihydrofolate reductase</p> Signup and view all the answers

    Which compound is directly inhibited by sulfanilamide in the presence of PABA?

    <p>Dihydropteroate</p> Signup and view all the answers

    What is the result of the synergistic effect in the combination of trimethoprim and sulfamethoxazole?

    <p>They inhibit separate pathways in folate synthesis</p> Signup and view all the answers

    Why are humans not affected by sulfanilamide in the same way as microbes?

    <p>Humans have a different structural enzyme than microbes</p> Signup and view all the answers

    Which of the following correctly illustrates the difference in folic acid permeability between humans and microbes?

    <p>Microbes are impermeable to folic acid unlike humans</p> Signup and view all the answers

    Which of the following drugs is not effective against beta-lactamase producing bacteria?

    <p>Ampicillin</p> Signup and view all the answers

    What is a common non-allergic adverse effect of penicillin?

    <p>Gastrointestinal symptoms</p> Signup and view all the answers

    Which cephalosporin class adverse effect can occur when taken with alcohol?

    <p>Liver toxicity</p> Signup and view all the answers

    Imipenem is effective against which of the following?

    <p>Gram-positive, Gram-negative, and anaerobes</p> Signup and view all the answers

    Which of these antibiotics is known for its role against Methicillin Resistant Staphylococcus aureus (MRSA)?

    <p>Oxacillin</p> Signup and view all the answers

    What is the primary reason the administration of Ticarcillin could be associated with sodium overload?

    <p>It contains a high sodium salt.</p> Signup and view all the answers

    Which combination acts as a beta-lactamase inhibitor?

    <p>Ampicillin and sulbactam</p> Signup and view all the answers

    What distinguishes Ticarcillin from Carbenicillin?

    <p>Ticarcillin is more potent against pseudomonas.</p> Signup and view all the answers

    What classification of antimicrobials describes their ability to target specific types of bacteria?

    <p>Spectrum of activity</p> Signup and view all the answers

    Which type of antimicrobial is known to inhibit bacterial growth without killing the bacteria?

    <p>Bacteriostatic</p> Signup and view all the answers

    Which bacterial type is likely to be targeted by a bactericidal antimicrobial?

    <p>Staphylococcus aureus</p> Signup and view all the answers

    Which class of antibiotics is often produced naturally and derived from fungi or bacteria?

    <p>Natural</p> Signup and view all the answers

    What characteristic distinguishes bacteriostatic antimicrobials from bactericidal ones?

    <p>They inhibit growth without killing.</p> Signup and view all the answers

    Which mechanism of action is involved in the selective inhibition of bacterial targets by antimicrobials?

    <p>Disruption of cell wall synthesis</p> Signup and view all the answers

    In which of the following conditions would a broad-spectrum antimicrobial be most appropriately used?

    <p>When the specific pathogen is unknown</p> Signup and view all the answers

    Which classification of antimicrobials encompasses those that are developed wholly through chemical synthesis?

    <p>Synthetic</p> Signup and view all the answers

    Study Notes

    Antimicrobials Overview

    • Antimicrobials are categorized by chemical structure, source (natural, synthetic, semisynthetic), spectrum of activity (narrow vs. broad), antimicrobial activity (bacteriostatic vs. bactericidal), kinetic properties (oral/systemic), and mechanism of action.
    • Classification includes Gram-positive and Gram-negative bacteria, distinguished by the Gram staining method developed by Hans Christian Gram in 1884.

    Bacterial Pathogens

    • Streptococcus pneumoniae: causes pneumonia.
    • Escherichia coli: responsible for urinary tract infections (UTIs).
    • Group A Streptococcus: associated with tonsillitis and pharyngitis.
    • Neisseria gonorrhea: a causative agent of sexually transmitted diseases (STDs).
    • Pseudomonas aeruginosa: common in hospital settings.
    • Mycoplasma pneumonia: also leads to pneumonia, lacks a cell wall.
    • Chlamydia trachomatis: associated with STDs.

    Mechanism of Action

    • Sulfanilamide acts as a competitive inhibitor of dihydropteroate synthase, mimicking p-aminobenzoic acid (PABA).
    • Selective inhibition occurs because microbes synthesize precursors to dihydrofolic acid, which humans do not.
    • Trimethoprim inhibits microbial dihydrofolate reductase, distinguishing it from human enzymes.
    • Co-trimoxazole (Trimethoprim + Sulfamethoxazole) shows a synergistic bactericidal effect when used together.

    Clinical Use of Sulfonamides

    • Sulfonamides are used for the treatment and prevention of UTIs due to gram-negative bacteria.
    • Side effects include photosensitivity, hemolytic anemia, renal damage due to crystal deposition, and potential kernicterus in neonates.
    • Trimethoprim is well-tolerated but can cause rash, nausea, and folate deficiency complications in susceptible populations.

    Penicillin Types and Effects

    • Extended Spectrum Aminopenicillins (e.g., Ampicillin, Amoxicillin) cover some gram-negative bacteria, with Amoxicillin having better bioavailability.
    • Penicillinase-resistant penicillins (e.g., Oxacillin, Nafcillin) are effective against beta-lactamase producing organisms.
    • Adverse effects of penicillins include allergic reactions, gastrointestinal symptoms, and potential seizures.

    Cephalosporins

    • Broad-spectrum antibiotics with potential adverse effects including diarrhea, nephrotoxicity, and allergic reactions.
    • Some cephalosporins may cause liver toxicity if taken with alcohol, and can impact pregnancy outcomes.

    Carbapenems

    • Imipenem has a broad spectrum and is resistant to most beta-lactamases but can cause seizures and increase bleeding tendency.
    • Meropenem has a lower seizure risk compared to Imipenem.
    • Aztreonam is effective against gram-negative infections and has no cross-reactivity with penicillins, making it well tolerated.

    Vancomycin

    • Vancomycin is a last-resort treatment for methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE).
    • It is also used for oral treatment of Clostridium difficile colitis.
    • No absorption occurs with oral Vancomycin, making it effective only for gastrointestinal infections when delivered orally.

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    Description

    Test your knowledge on antimicrobials as discussed in 'Pharmacology for Nursing Care' by Lehne. This quiz covers essential bacterial classifications, including the differences between gram-positive and gram-negative bacteria. Learn about historical figures like Hans Christian Gram and their contributions to microbiology.

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