Pharmacology: Drugs Affecting Coagulation & Bleeding
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Questions and Answers

What is the main indication for the use of fibrinolytic drugs?

  • Acute Myocardial Infarction (correct)
  • Venous thromboembolism
  • Pulmonary embolism
  • Deep vein thrombosis

What is the mechanism of action of aspirin on platelet aggregation?

  • Acetylation of COX1 and TX-synthase (correct)
  • Inhibition of COX2 enzyme
  • Inhibition of thromboxane A2
  • Stimulation of prostacyclin production

What is the duration of aspirin-induced antiplatelet effect?

  • 5-7 days (correct)
  • 3-5 days
  • 10-14 days
  • 7-10 days

What is the primary use of anti-platelet drugs?

<p>Prevention of thromboembolic disorders (C)</p> Signup and view all the answers

What is the result of damage to vascular endothelium?

<p>Release of proaggregatory and vasoconstrictor mediators (A)</p> Signup and view all the answers

What is the primary mechanism of action of fibrinolytic drugs?

<p>Activation of the fibrinolytic system (C)</p> Signup and view all the answers

What is the main adverse effect of fibrinolytic drugs?

<p>Bleeding (B)</p> Signup and view all the answers

What is the indication for the use of Vit K1-specific antidote?

<p>Hemorrhage due to warfarin (C)</p> Signup and view all the answers

What is the teratogenic effect of warfarin?

<p>Both A and B (C)</p> Signup and view all the answers

What is the primary site of action of aspirin?

<p>Portal circulation (B)</p> Signup and view all the answers

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