Pharmacology: Drugs Affecting Coagulation & Bleeding
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Questions and Answers

What is the main indication for the use of fibrinolytic drugs?

  • Acute Myocardial Infarction (correct)
  • Venous thromboembolism
  • Pulmonary embolism
  • Deep vein thrombosis

    • What is the mechanism of action of aspirin on platelet aggregation?

  • Acetylation of COX1 and TX-synthase (correct)
  • Inhibition of COX2 enzyme
  • Inhibition of thromboxane A2
  • Stimulation of prostacyclin production

    • What is the duration of aspirin-induced antiplatelet effect?

  • 5-7 days (correct)
  • 3-5 days
  • 10-14 days
  • 7-10 days

    • What is the primary use of anti-platelet drugs?

    <p>Prevention of thromboembolic disorders</p> Signup and view all the answers

    What is the result of damage to vascular endothelium?

    <p>Release of proaggregatory and vasoconstrictor mediators</p> Signup and view all the answers

    What is the primary mechanism of action of fibrinolytic drugs?

    <p>Activation of the fibrinolytic system</p> Signup and view all the answers

    What is the main adverse effect of fibrinolytic drugs?

    <p>Bleeding</p> Signup and view all the answers

    What is the indication for the use of Vit K1-specific antidote?

    <p>Hemorrhage due to warfarin</p> Signup and view all the answers

    What is the teratogenic effect of warfarin?

    <p>Both A and B</p> Signup and view all the answers

    What is the primary site of action of aspirin?

    <p>Portal circulation</p> Signup and view all the answers

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