Podcast
Questions and Answers
Which disorder is characterized by progressive loss of bone mass and skeletal fragility?
Which disorder is characterized by progressive loss of bone mass and skeletal fragility?
In which disorder do patients experience disorganized bone formation and enlarged or misshapen bones?
In which disorder do patients experience disorganized bone formation and enlarged or misshapen bones?
What is the most common age group affected by osteoporosis?
What is the most common age group affected by osteoporosis?
Which disorder is primarily attributed to vitamin D deficiency?
Which disorder is primarily attributed to vitamin D deficiency?
Signup and view all the answers
What is a common symptom of Paget disease?
What is a common symptom of Paget disease?
Signup and view all the answers
Which condition results in an increased risk of fractures due to skeletal fragility?
Which condition results in an increased risk of fractures due to skeletal fragility?
Signup and view all the answers
What adverse effect is associated with oral bisphosphonates?
What adverse effect is associated with oral bisphosphonates?
Signup and view all the answers
How can patients minimize esophageal irritation when taking oral bisphosphonates?
How can patients minimize esophageal irritation when taking oral bisphosphonates?
Signup and view all the answers
What is a rare adverse effect associated with bisphosphonates that affects the jaw and femur?
What is a rare adverse effect associated with bisphosphonates that affects the jaw and femur?
Signup and view all the answers
How often is denosumab administered for the treatment of postmenopausal osteoporosis?
How often is denosumab administered for the treatment of postmenopausal osteoporosis?
Signup and view all the answers
Which drug is considered a first-line agent for treating osteoporosis in high-risk fracture patients?
Which drug is considered a first-line agent for treating osteoporosis in high-risk fracture patients?
Signup and view all the answers
What is a potential adverse effect associated with denosumab use?
What is a potential adverse effect associated with denosumab use?
Signup and view all the answers
Which adverse effects are associated with calcium supplementation?
Which adverse effects are associated with calcium supplementation?
Signup and view all the answers
What should patients at risk for osteoporosis avoid in terms of drugs?
What should patients at risk for osteoporosis avoid in terms of drugs?
Signup and view all the answers
Which of the following can interfere with the absorption of iron preparations, thyroid replacement, and certain antibiotics?
Which of the following can interfere with the absorption of iron preparations, thyroid replacement, and certain antibiotics?
Signup and view all the answers
What is essential for the absorption of calcium and bone health?
What is essential for the absorption of calcium and bone health?
Signup and view all the answers
In whom is pharmacologic therapy for osteoporosis warranted?
In whom is pharmacologic therapy for osteoporosis warranted?
Signup and view all the answers
Which class of drugs, including alendronate, risedronate, and zoledronic acid, is preferred for treating postmenopausal osteoporosis?
Which class of drugs, including alendronate, risedronate, and zoledronic acid, is preferred for treating postmenopausal osteoporosis?
Signup and view all the answers
What is the mechanism of action of teriparatide and abaloparatide on bone metabolism?
What is the mechanism of action of teriparatide and abaloparatide on bone metabolism?
Signup and view all the answers
What is a common risk associated with cumulative lifetime use of teriparatide or abaloparatide for more than 2 years?
What is a common risk associated with cumulative lifetime use of teriparatide or abaloparatide for more than 2 years?
Signup and view all the answers
Why is estrogen replacement therapy no longer recommended as a preventive therapy for osteoporosis?
Why is estrogen replacement therapy no longer recommended as a preventive therapy for osteoporosis?
Signup and view all the answers
What is the primary effect of other drugs used for osteoporosis, unlike teriparatide and abaloparatide?
What is the primary effect of other drugs used for osteoporosis, unlike teriparatide and abaloparatide?
Signup and view all the answers
Which adverse effect is commonly associated with teriparatide and abaloparatide use?
Which adverse effect is commonly associated with teriparatide and abaloparatide use?
Signup and view all the answers
For which group of patients are teriparatide and abaloparatide generally reserved?
For which group of patients are teriparatide and abaloparatide generally reserved?
Signup and view all the answers
What is the mechanism of action of raloxifene in treating osteoporosis?
What is the mechanism of action of raloxifene in treating osteoporosis?
Signup and view all the answers
Which adverse effect is associated with the use of raloxifene?
Which adverse effect is associated with the use of raloxifene?
Signup and view all the answers
Why is raloxifene recommended as an alternative to bisphosphonates for postmenopausal osteoporosis?
Why is raloxifene recommended as an alternative to bisphosphonates for postmenopausal osteoporosis?
Signup and view all the answers
What is the indication for salmon calcitonin in treating osteoporosis?
What is the indication for salmon calcitonin in treating osteoporosis?
Signup and view all the answers
Why is salmon calcitonin less routinely recommended for osteoporosis treatment than other agents?
Why is salmon calcitonin less routinely recommended for osteoporosis treatment than other agents?
Signup and view all the answers
Which formulation of salmon calcitonin is most commonly used in osteoporosis?
Which formulation of salmon calcitonin is most commonly used in osteoporosis?
Signup and view all the answers
Which drug is indicated for the prevention and treatment of osteoporosis, with estrogen-like effects on bone and estrogen antagonist effects on breast and endometrial tissue?
Which drug is indicated for the prevention and treatment of osteoporosis, with estrogen-like effects on bone and estrogen antagonist effects on breast and endometrial tissue?
Signup and view all the answers
What is the primary adverse effect associated with raloxifene use?
What is the primary adverse effect associated with raloxifene use?
Signup and view all the answers
Why should raloxifene be considered as an alternative to bisphosphonates or denosumab in the treatment of postmenopausal osteoporosis?
Why should raloxifene be considered as an alternative to bisphosphonates or denosumab in the treatment of postmenopausal osteoporosis?
Signup and view all the answers
Which drug is indicated for the treatment of osteoporosis in women who are at least 5 years postmenopausal and reduces bone resorption?
Which drug is indicated for the treatment of osteoporosis in women who are at least 5 years postmenopausal and reduces bone resorption?
Signup and view all the answers
What is a common adverse effect associated with calcitonin use for osteoporosis?
What is a common adverse effect associated with calcitonin use for osteoporosis?
Signup and view all the answers
Why is calcitonin less effective than other agents for treating osteoporosis?
Why is calcitonin less effective than other agents for treating osteoporosis?
Signup and view all the answers
What distinguishes raloxifene from calcitonin in their respective mechanisms of action for treating osteoporosis?
What distinguishes raloxifene from calcitonin in their respective mechanisms of action for treating osteoporosis?
Signup and view all the answers
Why is raloxifene preferred over bisphosphonates or denosumab for postmenopausal osteoporosis treatment?
Why is raloxifene preferred over bisphosphonates or denosumab for postmenopausal osteoporosis treatment?
Signup and view all the answers
What is a significant differentiating factor between the intranasal and other formulations of salmon calcitonin?
What is a significant differentiating factor between the intranasal and other formulations of salmon calcitonin?
Signup and view all the answers
Which agent is considered less effective than other drugs for treating osteoporosis?
Which agent is considered less effective than other drugs for treating osteoporosis?
Signup and view all the answers