Podcast
Questions and Answers
What is the main mechanism of drug elimination through biotransformation?
What is the main mechanism of drug elimination through biotransformation?
- Phase II reactions
- Either phase I or phase II reactions (correct)
- Phase I reactions
- Liver microsomal enzyme systems
Where are the specific enzyme systems that catalyze metabolism located?
Where are the specific enzyme systems that catalyze metabolism located?
- Brain
- Lungs
- Kidneys
- Liver (correct)
What is the effect of biotransformation on the pharmacologic action of the parent drug?
What is the effect of biotransformation on the pharmacologic action of the parent drug?
- It terminates the action (correct)
- It has no effect
- It intensifies the action
- It increases the action
What is the term for the process where a more toxic metabolite is produced?
What is the term for the process where a more toxic metabolite is produced?
What is the term for a drug that is biotransformed into a pharmacologically active metabolite?
What is the term for a drug that is biotransformed into a pharmacologically active metabolite?
What is the effect of biotransformation on the biological half-life of a drug?
What is the effect of biotransformation on the biological half-life of a drug?
What is the reason for the increased incidence of toxicity with propranolol and lignocaine in elderly?
What is the reason for the increased incidence of toxicity with propranolol and lignocaine in elderly?
What is the term for the study of genetically determined variation in drug response?
What is the term for the study of genetically determined variation in drug response?
What is the result of chronic diseases of liver on hepatic metabolism of some drugs?
What is the result of chronic diseases of liver on hepatic metabolism of some drugs?
Why do neonates conjugate chloramphenicol more slowly?
Why do neonates conjugate chloramphenicol more slowly?
What is the characteristic of fast acetylators of isoniazid?
What is the characteristic of fast acetylators of isoniazid?
What is the result of atypical pseudocholinesterase metabolizing succinylcholine?
What is the result of atypical pseudocholinesterase metabolizing succinylcholine?
What is the effect of poor nutrition on enzyme function?
What is the effect of poor nutrition on enzyme function?
What is the importance of G6PD activity in RBCs?
What is the importance of G6PD activity in RBCs?
What is the effect of simultaneous administration of drugs on drug metabolism?
What is the effect of simultaneous administration of drugs on drug metabolism?
Where are the drug-metabolizing enzyme systems localized?
Where are the drug-metabolizing enzyme systems localized?
What is the effect of enzyme induction and enzyme inhibition on drug interactions?
What is the effect of enzyme induction and enzyme inhibition on drug interactions?
What type of factors play an important role in regulating the activity of drug-metabolizing enzyme systems?
What type of factors play an important role in regulating the activity of drug-metabolizing enzyme systems?
What is a known factor that stimulates the activity of drug-metabolizing enzymes in the liver microsomes?
What is a known factor that stimulates the activity of drug-metabolizing enzymes in the liver microsomes?
What is the purpose of pretreating the second mouse with phenobarbitone in Experiment 1?
What is the purpose of pretreating the second mouse with phenobarbitone in Experiment 1?
What is the effect of starvation on the biotransformation of thiopental?
What is the effect of starvation on the biotransformation of thiopental?
What is the outcome of pretreating the mouse with an enzyme inducer such as phenobarbitone?
What is the outcome of pretreating the mouse with an enzyme inducer such as phenobarbitone?
What is the dose of thiopental administered to the mice in Experiment 1?
What is the dose of thiopental administered to the mice in Experiment 1?
