Podcast
Questions and Answers
How does a low pH, or acidic environment affect drug absorption?
How does a low pH, or acidic environment affect drug absorption?
Which of the following factors is NOT a major influence on drug absorption in children?
Which of the following factors is NOT a major influence on drug absorption in children?
At what age does gastric acid secretion in infants generally reach adult levels?
At what age does gastric acid secretion in infants generally reach adult levels?
Which of the following statements is TRUE in infants regarding drug absorption?
Which of the following statements is TRUE in infants regarding drug absorption?
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What factors affect drug absorption in infants, specifically regarding the GI tract?
What factors affect drug absorption in infants, specifically regarding the GI tract?
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Study Notes
Drug Absorption Factors
- Drug absorption is affected by factors like age, health, weight, and administration route.
- Absorption generally improves as children grow, but neonates and infants have less developed absorption, impacting dosage.
- Adolescents may show slower absorption due to nutritional habits, physical maturity changes, and hormonal differences.
- Hydration, underlying diseases, and GI disorders significantly alter drug absorption.
Oral Drug Absorption
- Oral drug absorption is influenced by stomach and intestinal conditions.
- Factors include gastric acidity, emptying/motility, GI surface area, enzyme levels, and intestinal flora.
- GI tract immaturity significantly affects absorption in newborns and infants.
- Gastric pH is initially alkaline at birth, becoming acidic with development.
- Acidic drugs are better absorbed in acidic environments, while basic drugs are better absorbed in alkaline environments.
- Gastric emptying and GI motility are unpredictable in neonates/infants, but become more adult-like between 6-8 months.
- Feeding type (breastfed vs. formula-fed) affects gastric emptying rates.
- Unpredictable motility can hinder or enhance oral drug absorption based on the absorption site.
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Description
Explore the various factors affecting drug absorption in this quiz. Learn how age, health conditions, and the route of administration influence the absorption process. Understand the intricacies of oral drug absorption and the impact of gastric conditions on drug efficacy.
