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Questions and Answers
What is the primary function of diuretic drugs?
What is the primary function of diuretic drugs?
- To inhibit the secretion of Anti-Diuretic Hormone
- To decrease cardiac output
- To promote urine output by acting on the kidneys (correct)
- To increase glomerular filtration rate
Which of the following substances do diuretics primarily affect the reabsorption of?
Which of the following substances do diuretics primarily affect the reabsorption of?
- Glucose and urea
- Creatinine and phosphate
- Sodium, chloride, and bicarbonate (correct)
- Potassium and magnesium
Which condition is NOT typically treated with diuretic drugs?
Which condition is NOT typically treated with diuretic drugs?
- Sepsis (correct)
- Hypertension
- Liver cirrhosis
- Congestive heart failure
What effect do diuretic drugs have on tubular reabsorption?
What effect do diuretic drugs have on tubular reabsorption?
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Which of the following classifications of diuretics includes Acetazolamide?
Which of the following classifications of diuretics includes Acetazolamide?
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Study Notes
Diuretic Drugs Overview
- Diuretic drugs increase urine output by acting on the kidneys.
- They promote the excretion of water and ions, specifically sodium (Na), chloride (Cl), and bicarbonates (HCO3).
- Key renal processes involved in urine formation include glomerular filtration, tubular reabsorption, and tubular secretion.
Mechanism of Action
- Diuretics primarily function by decreasing tubular reabsorption, which enhances glomerular filtration.
- They do not influence the glomerular filtration rate (GFR) or the effects of Anti-Diuretic Hormone (ADH) in the nephron's distal portion.
Therapeutic Uses
- Effective in treating cardiac oedema, particularly related to congestive heart failure.
- Also used for conditions like nephrotic syndrome, diabetes insipidus, hypertension, nutritional oedema, oedema of pregnancy, and liver cirrhosis.
- Diuretics help reduce intracellular pressure and cerebrospinal fluid pressure.
Classification of Diuretics
- Carbonic Anhydrase Inhibitors:
- Examples include Acetazolamide, Methazolamide, and Dichlorphenamide.
- Thiazide Derivatives:
- Chlorothiazide and its analogues are key examples in this category.
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