Drug Interactions and Effects of COX-2 Inhibitors Quiz
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Questions and Answers

Which adverse effect is most associated with the use of COX-2 inhibitors?

  • Cardiovascular events (correct)
  • Nephrotoxic effects
  • Gastrointestinal bleeding
  • Bronchospasm
  • Which drug interaction can exacerbate the nephrotoxic effects of cyclosporine and tacrolimus?

  • Antiplatelet agents
  • Anticoagulants
  • NSAIDs (correct)
  • Cytotoxics
  • Among the listed NSAIDs, which one has the lowest rate of ulceration?

  • Celecoxib (correct)
  • Valdecoxib
  • Rofecoxib
  • Etoricoxib
  • What is the main concern that led to the restriction or withdrawal of most coxibs from the market?

    <p>Cardiovascular events</p> Signup and view all the answers

    Which COX-2 inhibitor has the highest degree of selectivity for COX-2 inhibition among those listed?

    <p>Lumiracoxib</p> Signup and view all the answers

    What is the advantage of treating subjects with 7.5 mg/day of meloxicam compared to piroxicam (20 mg/day)?

    <p>It causes less gastric injury</p> Signup and view all the answers

    Which NSAID is associated with fewer clinical gastrointestinal symptoms and complications than piroxicam, diclofenac, and naproxen?

    <p>Meloxicam</p> Signup and view all the answers

    How does meloxicam interact with antihypertensive and diuretic agents?

    <p>Interferes with their action</p> Signup and view all the answers

    Which drug class may have its antihypertensive effect blunted by meloxicam?

    <p>Angiotensin converting enzyme (ACE) inhibitors</p> Signup and view all the answers

    What adverse event may occur if NSAIDs like meloxicam are co-administered with quinolone antimicrobials?

    <p>Convulsions</p> Signup and view all the answers

    Which potential side effects should be monitored in elderly patients or those with underlying psychiatric disorders when administering indomethacin?

    <p>Severe depression and psychosis</p> Signup and view all the answers

    Which NSAID is well-tolerated in patients with familial intestinal polyposis due to sparing renal prostaglandin production?

    <p>Sulindac</p> Signup and view all the answers

    What type of adverse effect is common with most traditional NSAIDs during the dosing interval?

    <p>Hematologic reactions</p> Signup and view all the answers

    Which NSAID has the most COX-2 selective action among traditional NSAIDs?

    <p>Etodolac</p> Signup and view all the answers

    Which NSAID has a longer half-life due to its ability to accumulate in synovial fluid?

    <p>Diclofenac</p> Signup and view all the answers

    Which of the following is NOT a class of NSAIDs?

    <p>Benzothiazines</p> Signup and view all the answers

    Which of the following is an example of a COX-2 inhibitor NSAID?

    <p>Celecoxib</p> Signup and view all the answers

    What percentage of people over 65 use NSAIDs with or without a prescription?

    <p>10-40%</p> Signup and view all the answers

    Which of the following effects is NOT associated with NSAIDs?

    <p>Anticoagulant effect</p> Signup and view all the answers

    Approximately how many individuals consume NSAIDs every day worldwide?

    <p>30 million</p> Signup and view all the answers

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