20 Questions
Which adverse effect is most associated with the use of COX-2 inhibitors?
Cardiovascular events
Which drug interaction can exacerbate the nephrotoxic effects of cyclosporine and tacrolimus?
NSAIDs
Among the listed NSAIDs, which one has the lowest rate of ulceration?
Celecoxib
What is the main concern that led to the restriction or withdrawal of most coxibs from the market?
Cardiovascular events
Which COX-2 inhibitor has the highest degree of selectivity for COX-2 inhibition among those listed?
Lumiracoxib
What is the advantage of treating subjects with 7.5 mg/day of meloxicam compared to piroxicam (20 mg/day)?
It causes less gastric injury
Which NSAID is associated with fewer clinical gastrointestinal symptoms and complications than piroxicam, diclofenac, and naproxen?
Meloxicam
How does meloxicam interact with antihypertensive and diuretic agents?
Interferes with their action
Which drug class may have its antihypertensive effect blunted by meloxicam?
Angiotensin converting enzyme (ACE) inhibitors
What adverse event may occur if NSAIDs like meloxicam are co-administered with quinolone antimicrobials?
Convulsions
Which potential side effects should be monitored in elderly patients or those with underlying psychiatric disorders when administering indomethacin?
Severe depression and psychosis
Which NSAID is well-tolerated in patients with familial intestinal polyposis due to sparing renal prostaglandin production?
Sulindac
What type of adverse effect is common with most traditional NSAIDs during the dosing interval?
Hematologic reactions
Which NSAID has the most COX-2 selective action among traditional NSAIDs?
Etodolac
Which NSAID has a longer half-life due to its ability to accumulate in synovial fluid?
Diclofenac
Which of the following is NOT a class of NSAIDs?
Benzothiazines
Which of the following is an example of a COX-2 inhibitor NSAID?
Celecoxib
What percentage of people over 65 use NSAIDs with or without a prescription?
10-40%
Which of the following effects is NOT associated with NSAIDs?
Anticoagulant effect
Approximately how many individuals consume NSAIDs every day worldwide?
30 million
Test your knowledge on drug interactions involving anticoagulants, antiplatelet agents, cyclosporine, tacrolimus, and cytotoxics with NSAIDs, as well as the specific effects and prototype of COX-2 Inhibitors. Explore the risks, contraindications, and benefits associated with these medications.
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