Drug Interactions and Effects of COX-2 Inhibitors Quiz
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Questions and Answers

Which adverse effect is most associated with the use of COX-2 inhibitors?

  • Cardiovascular events (correct)
  • Nephrotoxic effects
  • Gastrointestinal bleeding
  • Bronchospasm

Which drug interaction can exacerbate the nephrotoxic effects of cyclosporine and tacrolimus?

  • Antiplatelet agents
  • Anticoagulants
  • NSAIDs (correct)
  • Cytotoxics

Among the listed NSAIDs, which one has the lowest rate of ulceration?

  • Celecoxib (correct)
  • Valdecoxib
  • Rofecoxib
  • Etoricoxib

What is the main concern that led to the restriction or withdrawal of most coxibs from the market?

<p>Cardiovascular events (A)</p> Signup and view all the answers

Which COX-2 inhibitor has the highest degree of selectivity for COX-2 inhibition among those listed?

<p>Lumiracoxib (B)</p> Signup and view all the answers

What is the advantage of treating subjects with 7.5 mg/day of meloxicam compared to piroxicam (20 mg/day)?

<p>It causes less gastric injury (C)</p> Signup and view all the answers

Which NSAID is associated with fewer clinical gastrointestinal symptoms and complications than piroxicam, diclofenac, and naproxen?

<p>Meloxicam (D)</p> Signup and view all the answers

How does meloxicam interact with antihypertensive and diuretic agents?

<p>Interferes with their action (C)</p> Signup and view all the answers

Which drug class may have its antihypertensive effect blunted by meloxicam?

<p>Angiotensin converting enzyme (ACE) inhibitors (D)</p> Signup and view all the answers

What adverse event may occur if NSAIDs like meloxicam are co-administered with quinolone antimicrobials?

<p>Convulsions (B)</p> Signup and view all the answers

Which potential side effects should be monitored in elderly patients or those with underlying psychiatric disorders when administering indomethacin?

<p>Severe depression and psychosis (C)</p> Signup and view all the answers

Which NSAID is well-tolerated in patients with familial intestinal polyposis due to sparing renal prostaglandin production?

<p>Sulindac (C)</p> Signup and view all the answers

What type of adverse effect is common with most traditional NSAIDs during the dosing interval?

<p>Hematologic reactions (B)</p> Signup and view all the answers

Which NSAID has the most COX-2 selective action among traditional NSAIDs?

<p>Etodolac (B)</p> Signup and view all the answers

Which NSAID has a longer half-life due to its ability to accumulate in synovial fluid?

<p>Diclofenac (B)</p> Signup and view all the answers

Which of the following is NOT a class of NSAIDs?

<p>Benzothiazines (B)</p> Signup and view all the answers

Which of the following is an example of a COX-2 inhibitor NSAID?

<p>Celecoxib (A)</p> Signup and view all the answers

What percentage of people over 65 use NSAIDs with or without a prescription?

<p>10-40% (D)</p> Signup and view all the answers

Which of the following effects is NOT associated with NSAIDs?

<p>Anticoagulant effect (A)</p> Signup and view all the answers

Approximately how many individuals consume NSAIDs every day worldwide?

<p>30 million (A)</p> Signup and view all the answers

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