Pharmacology Contributions and Curriculum Quiz
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Questions and Answers

What does pharmacokinetics focus on?

  • What a drug does to the body
  • How drugs interact with each other
  • What the body does to a drug (correct)
  • How drugs are formulated

Which of the following is NOT one of the four stages of pharmacokinetics?

  • Metabolism
  • Absorption
  • Therapy (correct)
  • Distribution

Which route of drug administration involves bypassing the gastrointestinal tract?

  • Inhalation
  • Rectal
  • Intravenous (IV) (correct)
  • Oral (PO)

What is the main focus of pharmacodynamics?

<p>Drug action on the body (A)</p> Signup and view all the answers

Which phase of pharmacokinetics involves the movement of drug from site of administration to the bloodstream?

<p>Absorption (B)</p> Signup and view all the answers

Why are there various routes of drug administration?

<p>Based on physicochemical properties of drugs and therapeutic goals (C)</p> Signup and view all the answers

Who founded the Journal of Biological Chemistry in 1905?

<p>Crystallized insulin (C)</p> Signup and view all the answers

Which of the following topics is covered in the UCLA Pharmacology Curriculum?

<p>Pharmacokinetics (A)</p> Signup and view all the answers

In the grading policy, what percentage range indicates a 'Pass'?

<p>50-35 (A)</p> Signup and view all the answers

Which category of drugs are Xanthine derivatives classified under?

<p>Sympathomimetic CNS stimulants (B)</p> Signup and view all the answers

What is the main focus of Pharmacodynamics in pharmacology principles?

<p>Drugs affecting nervous systems (A)</p> Signup and view all the answers

What type of drugs are Anti-diabetic drugs classified as?

<p>Anti-hypertensive drugs (A)</p> Signup and view all the answers

What is the primary mechanism of drug absorption through membranes?

<p>Simple diffusion (D)</p> Signup and view all the answers

Which type of transport requires energy and transporters?

<p>Active transport (A)</p> Signup and view all the answers

Which transporter family is known for unidirectional drug extrusion using ATP?

<p>ABC transporter (A)</p> Signup and view all the answers

Which type of transport process has bidirectional drug uptake and extrusion without direct ATP usage?

<p>Endocytosis (C)</p> Signup and view all the answers

What does endocytosis involve in terms of bringing materials into a cell?

<p>Inward folding of the cell membrane (C)</p> Signup and view all the answers

Which type of transport is characterized by exceptionally large-sized drugs crossing the cell membrane?

<p>Endocytosis (D)</p> Signup and view all the answers

Which type of drug is more lipid soluble and has more absorption?

<p>Non-ionized drug (C)</p> Signup and view all the answers

What determines the degree of ionization of a drug?

<p>pKa value (A)</p> Signup and view all the answers

Which equation is used to calculate the degree of ionization of a drug?

<p><strong>Henderson-Hasselbalch equation</strong> (A)</p> Signup and view all the answers

Which factor mainly determines the bioavailability of a drug?

<p>Route of administration (B)</p> Signup and view all the answers

At what pH do the ionized and non-ionized forms of a drug exist in equal amounts?

<p>pH = pKa (A)</p> Signup and view all the answers

When pH is less than the pKa of a drug, which forms predominate?

<p><strong>Protonated forms</strong> (A)</p> Signup and view all the answers

What happens to the bioavailability of an orally administered drug compared to an intravenously administered drug?

<p>It decreases (A)</p> Signup and view all the answers

In terms of absorption, which type of drug is typically less absorbed due to being less lipid soluble?

<p><strong>Ionized drug</strong> (A)</p> Signup and view all the answers

What is the main effect of pH on absorption for weak acid drugs?

<p>Optimal at pH 1-2 (C)</p> Signup and view all the answers

Which type of drugs can be distributed from blood to tissues/cells?

<p>'Free' (unbound) drugs only (D)</p> Signup and view all the answers

What is the bioavailability of intravenously administered medication?

<p>100% (C)</p> Signup and view all the answers

Which factor influences the bioavailability of a drug dose administered orally?

<p>First-pass metabolism (A)</p> Signup and view all the answers

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