Podcast
Questions and Answers
Which mechanism of action involves the inhibition of RNA polymerase?
Which mechanism of action involves the inhibition of RNA polymerase?
- RNA polymerase inhibitor (DNA-dependent) (correct)
- Inhibition of arabinosyl transferases
- Inhibition of DNA integrase
- Prodrug and inhibition of the enoic reductase
What is a common adverse effect associated with certain antibiotics that causes discoloration in bodily fluids?
What is a common adverse effect associated with certain antibiotics that causes discoloration in bodily fluids?
- Orange coloration of fluids (urine, saliva, tears) (correct)
- Hepatotoxicity
- Increased uric acid levels in plasma
- Reversible optic neuritis
Which drug mechanism involves directly binding to reverse transcriptase?
Which drug mechanism involves directly binding to reverse transcriptase?
- Maraviroc
- Raltegravir
- Zidovudine (correct)
- Ethambutol
Which drug is recognized for causing reversible optic neuritis and color blindness to red and green?
Which drug is recognized for causing reversible optic neuritis and color blindness to red and green?
What mechanism describes a nucleoside analog that competitively blocks reverse transcriptase effects?
What mechanism describes a nucleoside analog that competitively blocks reverse transcriptase effects?
Flashcards
Mechanism of Action (Prodrugs)
Mechanism of Action (Prodrugs)
Mechanism in which a drug is inactive and needs biotransformation/alteration in order to fully exhibit its effect.
Reverse Transcriptase Inhibition
Reverse Transcriptase Inhibition
A class of drugs that stop the conversion of RNA to DNA, inhibiting viral replication. This is achieved by competing with the enzyme reverse transcriptase.
RNA Polymerase Inhibition (DNA-dependent)
RNA Polymerase Inhibition (DNA-dependent)
Targeting of the enzyme that builds DNA from a DNA template, halting viral replication.
Adverse Effect (Orange Coloration)
Adverse Effect (Orange Coloration)
Signup and view all the flashcards
Hepatotoxicity (Drug Side Effect)
Hepatotoxicity (Drug Side Effect)
Signup and view all the flashcards
Study Notes
Mechanisms of Action
- Enzymatic Inhibition: A prodrug inhibiting enoic reductase is listed.
- RNA Polymerase Inhibition: An inhibitor of RNA polymerase is mentioned.
- DNA-Dependent Inhibition: Inhibition of DNA-dependent processes is noted.
- Translational Alteration: An inhibitor of protein translation and membrane potential alteration is included.
Adverse Effects
- Fluid Color Changes: Orange coloration of fluids (urine, saliva, tears) is a potential side effect.
- Visual Disturbances: Reversible optic neuritis, leading to color blindness (red-green), is noted.
- Uric Acid Elevation: Increased blood uric acid levels are mentioned.
- Hepatotoxicity and Hemolytic Anemia: Hepatic damage and hemolytic anemia are potential side effects, especially in susceptible individuals.
Further Drug Actions
- Nucleoside Analog: A nucleoside analog that competitively inhibits reverse transcriptase.
- CCR5 Receptor Binding: A drug that binds to the CCR5 receptor.
- Direct Reverse Transcriptase Inhibition: A drug that directly blocks reverse transcriptase.
- DNA Integrase Inhibition: Inhibition of DNA integrase is a mechanism of action of some drugs.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
