Nature and Mechanisms of Adverse Drug Reactions (ADRs)
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Questions and Answers

Which of the following is an example of a unique syndrome caused only by a specific drug?

  • Bleeding with warfarin
  • Eosinophilia‐myalgia syndrome caused by some l‐tryptophan products (correct)
  • Vaginal cancer in young women caused by maternal exposure to diethylstilboestrol
  • Headache with glyceryltrinitrate

    • Which mechanism for ADRs is exemplified by prolongation of the QT interval on the electrocardiogram?

  • Additional (secondary) pharmacological actions (correct)
  • Desired pharmacological effect at another site
  • Exaggerated therapeutic response at target site
  • Triggering an immunological response

    • What is the general rule when assessing a potential adverse effect of a medicine?

  • Consider other potential causes (correct)
  • Only consider the therapeutic effect of the medicine
  • Dismiss the possibility of adverse effects
  • Ignore other potential causes

    • Which drug is known to cause oculomucocutaneous syndrome?

    <p>Practolol</p> Signup and view all the answers

    What is the basis for some ADRs, particularly when they are first identified?

    <p>Pharmacokinetic</p> Signup and view all the answers

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