Pharmacology Chapter on Drug Diffusion
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Questions and Answers

Which of the following statements about passive diffusion is NOT true?

  • It requires energy in the form of ATP. (correct)
  • It is not saturable.
  • It is dependent on the concentration gradient.
  • It is used by the vast majority of drugs.

Aqueous diffusion is not affected by the pH of the medium.

True (A)

What type of drugs does non-aqueous diffusion primarily involve?

Lipid soluble drugs

Drugs which closely resemble naturally occurring metabolites are involved in __________ transport.

<p>specialized</p> Signup and view all the answers

Match the type of drug diffusion with its characteristics:

<p>Passive diffusion = Concentration gradient dependent, no energy required Aqueous diffusion = Water-soluble, pores ≤ 0.4 nm Non-aqueous diffusion = Lipid soluble, pH dependent Specialized transport = Carrier-mediated, resembles metabolites</p> Signup and view all the answers

Which of the following examples illustrates non-aqueous diffusion?

<p>Sodium thiopental (C)</p> Signup and view all the answers

Flashcards

Passive diffusion

Drug movement from high to low concentration, no energy needed.

Aqueous diffusion

Water-soluble drug movement through pores (aquaporins).

Non-aqueous diffusion

Lipid-soluble drug movement across membranes.

Specialized transport

Drug movement with carriers, requiring energy.

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factors affecting specialized transport

Drug's resemblance to natural metabolites, limited lipid solubility and high molecular weight affect transport mechanisms.

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factors affecting passive diffusion

Drug concentration, molecular size, and membrane permeability.

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