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Lipid soluble drugs diffuse by dissolving in the lipoidal matrix of the membrane, and the rate of transport is proportional to the lipid : water partition coefficient of the drug
Lipid soluble drugs diffuse by dissolving in the lipoidal matrix of the membrane, and the rate of transport is proportional to the lipid : water partition coefficient of the drug
True
Passive diffusion occurs from low to high concentration gradient across the membrane
Passive diffusion occurs from low to high concentration gradient across the membrane
False
The ionization of a weak acid HA can be calculated using the equation: $[A^-] = rac{[HA]}{10^{ ext{pH} - ext{pKa}}}$
The ionization of a weak acid HA can be calculated using the equation: $[A^-] = rac{[HA]}{10^{ ext{pH} - ext{pKa}}}$
False
Most drugs are strong electrolytes that are nearly completely ionized at acidic as well as alkaline pH
Most drugs are strong electrolytes that are nearly completely ionized at acidic as well as alkaline pH
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A more lipid-soluble drug attains higher concentration in the membrane and diffuses slowly
A more lipid-soluble drug attains higher concentration in the membrane and diffuses slowly
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