Pharmacology Chapter 7: Radiopharmaceuticals
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Questions and Answers

What is the common use of 99mTc-pyrophosphate (PYP)?

  • Lung perfusion imaging
  • Bone imaging
  • Liver and spleen imaging
  • Myocardial infarct imaging and red blood cell labeling (correct)

    • What is the storage parameter for 99mTc-Macroaggregated Albumin (MAA) kits before labeling?

  • -20°C
  • Room temperature
  • 2-8°C (correct)
  • 15-30°C

    • What is the pH of 99mTc-Phosphonate?

  • 8
  • 5
  • 7.5 (correct)
  • 6-7

    • What is the common use of Filtered 99mTc-Sulfur Colloid?

    <p>Lymphoscintigraphy</p> Signup and view all the answers

    Does 99mTc-Phosphonate need to be heated?

    <p>No</p> Signup and view all the answers

    What is the half-life of 99mTc-Macroaggregated Albumin (MAA)?

    <p>6 hours</p> Signup and view all the answers

    What is the energy level of 99mTc-Technegas?

    <p>140 kev</p> Signup and view all the answers

    Which radiopharmaceutical has a half-life of 14.3 days?

    <p>32P-Sodium Orthophosphate</p> Signup and view all the answers

    What is the common use of 131I-Sodium Iodide?

    <p>Treatment of thyroid diseases</p> Signup and view all the answers

    Which radiopharmaceutical requires heating?

    <p>111In-DTPA (Pentetate) Indium Disodium</p> Signup and view all the answers

    What is the pH range of 123I-Ioflupane (DaTscan)?

    <p>4.2-5.2</p> Signup and view all the answers

    Which radiopharmaceutical has a color of purplish?

    <p>133Xe Gas-Xenon</p> Signup and view all the answers

    What is the half-life of 99mTc-Technegas?

    <p>6 hours</p> Signup and view all the answers

    Which radiopharmaceutical is used for the measurement of glomerular filtration?

    <p>125I-Sodium Iothalamate (Glofil)</p> Signup and view all the answers

    What is the energy level of 201Tl-Thallous Chloride?

    <p>68-80.3 KeV</p> Signup and view all the answers

    Which radiopharmaceutical is used for the treatment of polycythemia vera?

    <p>32P-Sodium Orthophosphate</p> Signup and view all the answers

    What is the energy of 99mTc-Tilmanocept (Lymphoseek)?

    <p>140 KeV</p> Signup and view all the answers

    What is the pH range for 99mTc-Hexamethylpropylene Amine Oxime HMPAO (Ceretec)?

    <p>9-9.8</p> Signup and view all the answers

    What is the common use of 99mTc-Albmun Colloid (Nanocolloid)?

    <p>Bone marrow imaging and inflammation scintigraphy</p> Signup and view all the answers

    What is the storage temperature for 99mTc-Pentetate (DTPA)?

    <p>15-30°C</p> Signup and view all the answers

    Which of the following radiopharmaceuticals requires heating during preparation?

    <p>99mTc-Sestamibi (Cardiolite)</p> Signup and view all the answers

    What is the common use of 99mTc-ECD Ethyl Cysteinate Dimer or Tc-99m Bicistate (Neurolite)?

    <p>Brain perfusion imaging</p> Signup and view all the answers

    What is the pH range for 99mTc-Dimercaptosuccinic Acid DMSA (Succimer)?

    <p>2-3 and 8-9</p> Signup and view all the answers

    What is the storage parameter for 99mTc-Labeled Red Blood Cells?

    <p>Room temperature</p> Signup and view all the answers

    What is the common use of 99mTc-Tetrofosmin (Myoview)?

    <p>Myocardial perfusion imaging</p> Signup and view all the answers

    What is the color of 99mTc-Hexamethylpropylene Amine Oxime HMPAO (Ceretec)?

    <p>Blue</p> Signup and view all the answers

    Which radiopharmaceutical has the shortest half-life?

    <p>N-13-Ammonia</p> Signup and view all the answers

    What is the pH range for F-18-Florbetapir?

    <p>4.5-7.5</p> Signup and view all the answers

    Which radiopharmaceutical is used for cerebral perfusion PET imaging?

    <p>N-13-Ammonia</p> Signup and view all the answers

    What is the energy of In-111-Ibritumomab Tiuxetan?

    <p>0.171 MeV</p> Signup and view all the answers

    Which radiopharmaceutical is used for detecting primary and metastatic neuroendocrine tumors?

    <p>In-111-Pentetreotide</p> Signup and view all the answers

    What is the half-life of Tc-99m-Sestamibi?

    <p>6 hours</p> Signup and view all the answers

    Which radiopharmaceutical is used for synthesis of F-18 fluorodeoxyglucose?

    <p>F-18-sodium fluoride</p> Signup and view all the answers

    Which radiopharmaceutical has the longest half-life?

    <p>67Ga-Gallium Citrate</p> Signup and view all the answers

    What is the energy of C-11-Choline?

    <p>0.960 MeV</p> Signup and view all the answers

    Which radiopharmaceutical is used for imaging of prostate cancer?

    <p>F-18-Fluciclovine</p> Signup and view all the answers

    Which radiopharmaceutical has an energy of 171 keV and 245 keV?

    <p>111In-Oxine</p> Signup and view all the answers

    What is the common use of Y90-TheraSphere?

    <p>Treatment of hepatocellular carcinoma</p> Signup and view all the answers

    Which radiopharmaceutical has a half-life of 271.79 days?

    <p>57Co-Cyanocobalamin</p> Signup and view all the answers

    What is the pH range of 111In-Oxine?

    <p>6.5 to 7.5</p> Signup and view all the answers

    Which radiopharmaceutical is used for the treatment of patients with castration-resistant prostate cancer?

    <p>Ra-223-Radium Chloride (Xofigo)</p> Signup and view all the answers

    What is the energy of 18-Florbetaben (Neuraceq)?

    <p>0.634 MeV</p> Signup and view all the answers

    Which radiopharmaceutical is used for labeling leukocytes and platelets?

    <p>111In-Oxine</p> Signup and view all the answers

    What is the storage parameter for 153Sm-Ethylenediaminetetramethylene Phosphonic Acid (Quadramet)?

    <p>Room temperature</p> Signup and view all the answers

    Which radiopharmaceutical has a half-life of 75 seconds?

    <p>Rb-82-Rubidium Chloride</p> Signup and view all the answers

    What is the common use of F-18-Flutemetamol (Vizamyl)?

    <p>Labeling of the brain to identify Alzheimer's Disease damage</p> Signup and view all the answers

    What is the common use of 99mTc-Macroaggregated Albumin (MAA)?

    <p>Lung perfusion imaging and venography</p> Signup and view all the answers

    Which of the following radiopharmaceuticals has a pH range of 6-7?

    <p>99mTc-Sulfur Colloid</p> Signup and view all the answers

    Which radiopharmaceutical requires heating during preparation?

    <p>99mTc-Sulfur Colloid</p> Signup and view all the answers

    What is the energy level of 99mTc-Pyrophosphate (PYP)?

    <p>140 KeV</p> Signup and view all the answers

    Which radiopharmaceutical has a half-life of 6 hours?

    <p>All of the above</p> Signup and view all the answers

    Which radiopharmaceutical is used for liver and spleen imaging?

    <p>99mTc-Sulfur Colloid</p> Signup and view all the answers

    Which radiopharmaceutical has a half-life of 60.14 days?

    <p>125I-Albumin Serum Albumin (RISA)</p> Signup and view all the answers

    What is the energy level of 111In-DTPA (Pentetate) Indium Disodium?

    <p>173 keV, 247 keV</p> Signup and view all the answers

    Which radiopharmaceutical is stored at -200°C to -10°C?

    <p>123I-Metaiodobenzylguanidine (AdreView)</p> Signup and view all the answers

    What is the pH range of 201Tl-Thallous Chloride?

    <p>4.5 to 7</p> Signup and view all the answers

    Which radiopharmaceutical is used for the measurement of blood volume and cardiac output?

    <p>125I-Albumin Serum Albumin (RISA)</p> Signup and view all the answers

    What is the energy level of 67Ga-Citrate?

    <p>93 keV, 184 keV, 296 keV and 388 keV</p> Signup and view all the answers

    Which radiopharmaceutical has a color of very pale yellow?

    <p>123I-Sodium Iodide</p> Signup and view all the answers

    What is the common use of 133Xe Gas-Xenon 133?

    <p>Ventilation studies of the lungs and also for the assessment of cerebral blood flow</p> Signup and view all the answers

    Which radiopharmaceutical requires heating in a water bath?

    <p>111In-DTPA (Pentetate) Indium Disodium</p> Signup and view all the answers

    What is the storage parameter for 125I-Sodium Iothalamate (Glofil)?

    <p>2-8°C</p> Signup and view all the answers

    Which radiopharmaceutical has a half-life of 64.1 hours?

    <p>Y90-SIR-Sphere (SIRTeX)</p> Signup and view all the answers

    Which of the following radiopharmaceuticals has an energy of 0.936 MeV?

    <p>Y90-TheraSphere</p> Signup and view all the answers

    Which radiopharmaceutical has a pH range of 6-8?

    <p>Ra-223- Radium Chloride (Xofigo)</p> Signup and view all the answers

    Which radiopharmaceutical is used for the treatment of liver cancer while waiting for a liver transplant?

    <p>Y90-TheraSphere</p> Signup and view all the answers

    Which radiopharmaceutical has a half-life of 2.8 days?

    <p>111In-Oxine</p> Signup and view all the answers

    Which radiopharmaceutical is used for labeling leukocytes and platelets?

    <p>111In-Oxine</p> Signup and view all the answers

    Which radiopharmaceutical has a color of yellow?

    <p>57Co- or 58Co-Cyanocobalamin</p> Signup and view all the answers

    Which radiopharmaceutical has a storage parameter of 15-30°C?

    <p>111In-Oxine</p> Signup and view all the answers

    Which radiopharmaceutical has an energy of 171 keV and 245 keV?

    <p>111In-Oxine</p> Signup and view all the answers

    Which radiopharmaceutical is used for imaging of neurodegenerative disorders including Alzheimer's disease?

    <p>18-Florbetaben (Neuraceq)</p> Signup and view all the answers

    What is the common use of 99mTc-Albmun Colloid (Nanocolloid)?

    <p>Bone marrow imaging, inflammation scintigraphy, and lymphoscintigraphy</p> Signup and view all the answers

    Which radiopharmaceutical has a pH range of 5-6?

    <p>99mTc-Mercaptoacetylglycylglycylglycine (MAG3)</p> Signup and view all the answers

    Which radiopharmaceutical requires heating during preparation?

    <p>99mTc-Sestamibi (Cardiolite)</p> Signup and view all the answers

    What is the storage parameter for 99mTc-Tilmanocept (Lymphoseek)?

    <p>Room temperature, and should be used within 8 hours after elution from the generator</p> Signup and view all the answers

    Which radiopharmaceutical has a color of blue?

    <p>99mTc-Hexamethylpropylene Amine Oxime HMPAO (Ceretec)</p> Signup and view all the answers

    Which radiopharmaceutical has a pH range of 7.5?

    <p>99mTc-Pentetate (DTPA)</p> Signup and view all the answers

    What is the energy level of 99mTc-Tilmanocept (Lymphoseek)?

    <p>140 KeV</p> Signup and view all the answers

    Which radiopharmaceutical has a common use of renal cortical imaging and medullary thyroid cancer?

    <p>99mTc-Dimercaptosuccinic Acid DMSA (Succimer)</p> Signup and view all the answers

    What is the storage parameter for 99mTc-Mercaptoacetylglycylglycylglycine (MAG3)?

    <p>15-30°C before and after labeling</p> Signup and view all the answers

    Which radiopharmaceutical has a pH range of 8.3-9.1?

    <p>99mTc-Tetrofosmin (Myoview)</p> Signup and view all the answers

    What is the energy level of F-18-Fluciclovine (Axumin)?

    <p>511 KeV</p> Signup and view all the answers

    Which radiopharmaceutical has a half-life of 2.8 days and is used for imaging agent to predict the distribution of the subsequent therapeutic dosage of 90Y-ibritumomab within the body?

    <p>In-111-Ibritumomab Tiuxetan</p> Signup and view all the answers

    What is the pH range of F-18-Florbetapir (Amyvid)?

    <p>4.5-7.5</p> Signup and view all the answers

    Which radiopharmaceutical has an energy level of 0.960 MeV and is used for detecting prostate cancer, brain, and breast cancers?

    <p>C-11-Choline</p> Signup and view all the answers

    What is the storage temperature for Tc-99m-MAG3 (Mertiatide)?

    <p>15-30°C</p> Signup and view all the answers

    Which radiopharmaceutical has an energy level of 1.1198 MeV and is used for cerebral perfusion PET imaging?

    <p>N-13-Ammonia</p> Signup and view all the answers

    What is the pH range of Tc-99m-Sestamibi (Miraluma)?

    <p>5.5</p> Signup and view all the answers

    Which radiopharmaceutical has an energy level of 140 KeV and is used for inflammation, abscess, or other infections?

    <p>Tc-99m-labeled WBCs</p> Signup and view all the answers

    What is the half-life of F-18-Sodium Fluoride?

    <p>110 minutes</p> Signup and view all the answers

    Which radiopharmaceutical has an energy level of 511 KeV and is used for metabolism studies in the brain and heart, early detection of epilepsy, and various tumors?

    <p>F-18-FDG</p> Signup and view all the answers

    Study Notes

    Radiopharmaceuticals

    • 99mTc-Macroaggregated Albumin (MAA)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: kits should be stored at 2-8°C before labeling with 99mTc, preparations are good for 6-8 h at 2-8°C after formulation
      • Color: cloudy
      • pH: 5
      • Common uses: lung perfusion imaging, venography to detect deep vein thrombi in lower extremities
      • Needs to be heated
    • 99mTc-Phosphonate
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C both before and after labeling (MDP: 6 hrs and HDP: 8 hrs)
      • Color: clear
      • pH: 7.5
      • Common uses: bone imaging (MDP and HDP)
      • No heating required
    • 99mTc-Sulfur Colloid
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: stored at room temperature and dispensed within 6-12 h after labeling
      • Color: cloudy
      • pH: 6-7 with a suitable buffer
      • Common uses: liver and spleen imaging, bone marrow, GI bleed, and making 99mTc-labeled egg sandwich for gastric emptying studies
      • Needs to be heated
    • Filtered 99mTc-Sulfur Colloid
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: stored at room temperature
      • Color: cloudy
      • pH: 6-7
      • Common uses: Lymphoscintigraphy
      • Needs to be heated
    • 99mTc-Albumin Colloid (Nanocolloid)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 2-8°C before reconstitution and at room temperature after reconstitution, useful for 6 h after formulation
      • Color: cloudy
      • pH: 6-7
      • Common uses: bone marrow imaging, inflammation scintigraphy, and lymphoscintigraphy (smaller size)
      • No heating required
    • 99mTc-Tilmanocept (Lymphoseek)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: room temperature, and should be used within 8 h after elution from the generator
      • Color: cloudy near clear
      • pH: 7.5
      • Common uses: detection of lymph nodes and guiding sentinel lymph node biopsy in patients with breast cancer, melanoma, and head and neck cancer
      • No heating required
    • 99mTc-Pentetate (DTPA)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C before and after labeling
      • Color: clear
      • pH: 7.5
      • Common uses: renal flow study, glomerular filtration rate (GFR) measurement, and aerosol preparation in lung ventilation studies
      • No heating required
    • 99mTc-Labeled Red Blood Cells
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: room temperature
      • Color: red
      • pH: 7.5
      • Common uses: blood pool imaging
      • No heating required
    • 99mTc-Iminodiacetic Acid Derivatives (DISIDA (Hepatolite), Mebrofenin (Choletec) )
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C both before and after labeling
      • Color: clear
      • pH: 7.5
      • Common uses: to evaluate hepatic function, biliary duct patency, and mainly in chole scintigraphy
      • No heating required
    • 99mTc-Hexamethylpropylene Amine Oxime (Ceretec)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 70°C
      • Color: blue
      • pH: High pH (9-9.8), decomposition still occurs to some extent at pH 6
      • Common uses: brain perfusion imaging primarily, labeling of leukocytes, substituting for 111In-oxine
      • No heating required
    • 99mTc-Sestamibi (Cardiolite)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C before and after reconstitution
      • Color: clear
      • pH: 5.5
      • Common uses: myocardial perfusion abnormalities, particularly myocardial ischemia and infarcts
      • Needs to be heated
    • 99mTc-Mercaptoacetylglycylglycine (MAG3)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C both before and after labeling, protect from light (light sensitive) until use
      • Color: clear
      • pH: 5-6
      • Common uses: assessment of renal function, particularly in renal transplants
      • Needs to be heated
    • ... (remaining radiopharmaceuticals omitted for brevity)

    Note: The remaining radiopharmaceuticals are listed in the original text, but omitted here for brevity.

    Radiopharmaceuticals

    • 99mTc-Macroaggregated Albumin (MAA)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: kits should be stored at 2-8°C before labeling with 99mTc, preparations are good for 6-8 h at 2-8°C after formulation
      • Color: cloudy
      • pH: 5
      • Common uses: lung perfusion imaging, venography to detect deep vein thrombi in lower extremities
      • Needs to be heated
    • 99mTc-Phosphonate
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C both before and after labeling (MDP: 6 hrs and HDP: 8 hrs)
      • Color: clear
      • pH: 7.5
      • Common uses: bone imaging (MDP and HDP)
      • No heating required
    • 99mTc-Sulfur Colloid
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: stored at room temperature and dispensed within 6-12 h after labeling
      • Color: cloudy
      • pH: 6-7 with a suitable buffer
      • Common uses: liver and spleen imaging, bone marrow, GI bleed, and making 99mTc-labeled egg sandwich for gastric emptying studies
      • Needs to be heated
    • Filtered 99mTc-Sulfur Colloid
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: stored at room temperature
      • Color: cloudy
      • pH: 6-7
      • Common uses: Lymphoscintigraphy
      • Needs to be heated
    • 99mTc-Albumin Colloid (Nanocolloid)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 2-8°C before reconstitution and at room temperature after reconstitution, useful for 6 h after formulation
      • Color: cloudy
      • pH: 6-7
      • Common uses: bone marrow imaging, inflammation scintigraphy, and lymphoscintigraphy (smaller size)
      • No heating required
    • 99mTc-Tilmanocept (Lymphoseek)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: room temperature, and should be used within 8 h after elution from the generator
      • Color: cloudy near clear
      • pH: 7.5
      • Common uses: detection of lymph nodes and guiding sentinel lymph node biopsy in patients with breast cancer, melanoma, and head and neck cancer
      • No heating required
    • 99mTc-Pentetate (DTPA)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C before and after labeling
      • Color: clear
      • pH: 7.5
      • Common uses: renal flow study, glomerular filtration rate (GFR) measurement, and aerosol preparation in lung ventilation studies
      • No heating required
    • 99mTc-Labeled Red Blood Cells
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: room temperature
      • Color: red
      • pH: 7.5
      • Common uses: blood pool imaging
      • No heating required
    • 99mTc-Iminodiacetic Acid Derivatives (DISIDA (Hepatolite), Mebrofenin (Choletec) )
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C both before and after labeling
      • Color: clear
      • pH: 7.5
      • Common uses: to evaluate hepatic function, biliary duct patency, and mainly in chole scintigraphy
      • No heating required
    • 99mTc-Hexamethylpropylene Amine Oxime (Ceretec)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 70°C
      • Color: blue
      • pH: High pH (9-9.8), decomposition still occurs to some extent at pH 6
      • Common uses: brain perfusion imaging primarily, labeling of leukocytes, substituting for 111In-oxine
      • No heating required
    • 99mTc-Sestamibi (Cardiolite)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C before and after reconstitution
      • Color: clear
      • pH: 5.5
      • Common uses: myocardial perfusion abnormalities, particularly myocardial ischemia and infarcts
      • Needs to be heated
    • 99mTc-Mercaptoacetylglycylglycine (MAG3)
      • Energies: 140 KeV
      • Half-life: 6 hours
      • Storage parameters: 15-30°C both before and after labeling, protect from light (light sensitive) until use
      • Color: clear
      • pH: 5-6
      • Common uses: assessment of renal function, particularly in renal transplants
      • Needs to be heated
    • ... (remaining radiopharmaceuticals omitted for brevity)

    Note: The remaining radiopharmaceuticals are listed in the original text, but omitted here for brevity.

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    This quiz covers the properties and uses of radiopharmaceuticals, including 99mTc-Macroaggregated Albumin and 99mTc-Phosphonate. Study online with Quizlet.

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